PMID- 33638245
OWN - NLM
STAT- MEDLINE
DCOM- 20220119
LR  - 20220119
IS  - 1600-0897 (Electronic)
IS  - 1046-7408 (Linking)
VI  - 86
IP  - 2
DP  - 2021 Aug
TI  - Association of circulating monocyte chemoattractant protein-1 levels with 
      polycystic ovary syndrome: A meta-analysis.
PG  - e13407
LID - 10.1111/aji.13407 [doi]
AB  - PROBLEM: Polycystic ovary syndrome (PCOS) is a common hormonal disorder that has 
      a huge impact on the human infertility. Increased levels of various circulating 
      inflammatory cytokines have been observed in PCOS patients, which can contribute 
      to the pathogenesis of PCOS. Monocyte chemoattractant protein-1 (MCP-1), a 
      secretory chemokine, is a potent chemotactic factor that recruits 
      monocytes/macrophages to inflammatory foci. Several previous studies comparing 
      the circulating MCP-1 levels between non-PCOS and PCOS patients have yielded 
      contradictory results. Therefore, the aim of this meta-analysis was to 
      investigate whether circulating MCP-1 levels vary between non-PCOS and PCOS 
      patients. METHODS: Research articles published before November 11, 2020, were 
      screened to identify eligible studies. Heterogeneity, sensitivity, and 
      publication bias were analyzed using STATA software. Standardized mean difference 
      (SMD) with a 95% confidence interval (CI) was calculated by the STATA software 
      using a random-effects model. RESULTS: 11 studies were included in this 
      meta-analysis involving 897 individuals: 368 non-PCOS patient and 529 PCOS 
      patients. Our pooled meta-analysis results show that circulating MCP-1 levels 
      were significantly higher in PCOS patients than in non-PCOS patients (SMD = 0.84, 
      95% CI = [0.37, 1.31], Z = 3.50, p < 0.01). However, due to the limited number of 
      studies included in this meta-analysis, subgroup analysis determined that 
      circulating MCP-1 levels were not significantly varied between obese non-PCOS and 
      obese PCOS patients (SMD = 0.42, 95% CI = [-0.65, 1.49], Z = 0.77, p = 0.442) as 
      well as between non-PCOS and PCOS patients without obesity (SMD = 2.04, 95% 
      CI = [-0.84, 4.93], Z = 1.39, p = 0.166). In addition, circulating MCP-1 levels 
      were also not significantly different between obese and non-obese PCOS patients 
      (SMD = -0.04, 95% CI = [-0.68, 0.60], Z = 0.11, p = 0.909). CONCLUSION: Our 
      findings reveal that circulating MCP-1 levels are upregulated in women with PCOS 
      and are associated with an increased risk of PCOS.
CI  - (c) 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Wu, Ze
AU  - Wu Z
AD  - Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and 
      Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 
      China.
FAU - Fang, Lanlan
AU  - Fang L
AD  - Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and 
      Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 
      China.
FAU - Li, Yuxi
AU  - Li Y
AD  - Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and 
      Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 
      China.
FAU - Yan, Yang
AU  - Yan Y
AD  - Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and 
      Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 
      China.
FAU - Thakur, Avinash
AU  - Thakur A
AD  - Department of Medical Genetics, University of British Columbia, Vancouver, 
      British Columbia, Canada.
AD  - Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada.
FAU - Cheng, Jung-Chien
AU  - Cheng JC
AUID- ORCID: 0000-0002-5399-9327
AD  - Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and 
      Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 
      China.
FAU - Sun, Ying-Pu
AU  - Sun YP
AD  - Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and 
      Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 
      China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20210309
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Obesity/*blood
MH  - Polycystic Ovary Syndrome/*blood
OTO - NOTNLM
OT  - MCP-1
OT  - PCOS
OT  - meta-analysis
EDAT- 2021/02/28 06:00
MHDA- 2022/01/20 06:00
CRDT- 2021/02/27 05:44
PHST- 2021/02/09 00:00 [revised]
PHST- 2020/11/13 00:00 [received]
PHST- 2021/02/22 00:00 [accepted]
PHST- 2021/02/28 06:00 [pubmed]
PHST- 2022/01/20 06:00 [medline]
PHST- 2021/02/27 05:44 [entrez]
AID - 10.1111/aji.13407 [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2021 Aug;86(2):e13407. doi: 10.1111/aji.13407. Epub 2021 Mar 
      9.