PMID- 33640889
OWN - NLM
STAT- MEDLINE
DCOM- 20220215
LR  - 20220215
IS  - 1421-9832 (Electronic)
IS  - 1018-8665 (Linking)
VI  - 237
IP  - 6
DP  - 2021
TI  - A History of Asthma Increases the Risk of Bullous Pemphigoid: Insights from a 
      Large Population-Based Study.
PG  - 921-928
LID - 10.1159/000512917 [doi]
AB  - BACKGROUND: Bullous pemphigoid (BP) and asthma both share a pathogenic role of 
      eosinophils and immunoglobulin E (IgE) and favorable response for corticosteroids 
      and omalizumab. However, the association between these conditions is yet to be 
      investigated. We sought to estimate the risk of having BP among patients 
      previously diagnosed with asthma and to characterize patients with coexistent BP 
      and asthma. METHODS: Utilizing the dataset of Clalit Health Services, a 
      population-based case-control study was conducted comparing BP patients (n = 
      3,924) with age-, sex-, and ethnicity-matched control subjects (n = 19,280) 
      regarding the presence of asthma. Logistic regression models were utilized for 
      univariate and multivariate analyses. RESULTS: The prevalence of preceding asthma 
      was higher in patients with BP than in control subjects (11.1 vs. 7.9%, 
      respectively; p < 0.001). A history of asthma was associated with a 50% increase 
      in the risk of BP (OR 1.45; 95% CI 1.30-1.62). The association was not altered 
      greatly after adjusting for demographics (adjusted OR 1.43; 95% CI 1.28-1.61) as 
      well as for demographics and comorbidities (adjusted OR 1.40; 95% CI 1.25-1.57). 
      The average (SD) latency between the diagnosis of asthma and the development of 
      BP was 12.5 (14.7) years. When compared with other patients with BP, those with a 
      dual diagnosis of BP and asthma were older, had higher BMI, and were more 
      frequently managed by corticosteroids and immunosuppressive and immunomodulatory 
      adjuvants. CONCLUSIONS: Asthma confers a predisposition to the development of BP. 
      Awareness of this association may be of help for physicians managing patients 
      with BP and asthma. Further research is required to elucidate the mechanism 
      underlying this observation.
CI  - (c) 2021 S. Karger AG, Basel.
FAU - Kridin, Khalaf
AU  - Kridin K
AD  - Lubeck Institute of Experimental Dermatology, University of Lubeck, Lubeck, 
      Germany, dr_kridin@hotmail.com.
AD  - Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel, 
      dr_kridin@hotmail.com.
FAU - Ludwig, Ralf J
AU  - Ludwig RJ
AD  - Lubeck Institute of Experimental Dermatology, University of Lubeck, Lubeck, 
      Germany.
FAU - Tzur Bitan, Dana
AU  - Tzur Bitan D
AD  - Department of Behavioral Sciences, Ariel University, Ariel, Israel.
FAU - Cohen, Arnon D
AU  - Cohen AD
AD  - Clalit Health Services, Tel-Aviv, Israel.
AD  - Siaal Research Center for Family Medicine and Primary Care, Faculty of Health 
      Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
LA  - eng
PT  - Journal Article
DEP - 20210226
PL  - Switzerland
TA  - Dermatology
JT  - Dermatology (Basel, Switzerland)
JID - 9203244
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asthma/*complications/diagnosis/*epidemiology
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Datasets as Topic
MH  - Female
MH  - Humans
MH  - Infant
MH  - Israel
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Pemphigoid, Bullous/*complications/diagnosis/*epidemiology
MH  - Prevalence
MH  - Young Adult
OTO - NOTNLM
OT  - Association
OT  - Asthma
OT  - Bullous pemphigoid
OT  - Case-control study
OT  - Comorbidity
EDAT- 2021/03/01 06:00
MHDA- 2022/02/16 06:00
CRDT- 2021/02/28 20:38
PHST- 2020/09/12 00:00 [received]
PHST- 2020/11/10 00:00 [accepted]
PHST- 2021/03/01 06:00 [pubmed]
PHST- 2022/02/16 06:00 [medline]
PHST- 2021/02/28 20:38 [entrez]
AID - 000512917 [pii]
AID - 10.1159/000512917 [doi]
PST - ppublish
SO  - Dermatology. 2021;237(6):921-928. doi: 10.1159/000512917. Epub 2021 Feb 26.