PMID- 33641081
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210417
IS  - 1869-6953 (Print)
IS  - 1869-6961 (Electronic)
IS  - 1869-6961 (Linking)
VI  - 12
IP  - 4
DP  - 2021 Apr
TI  - Ten-Year Outcomes of Percutaneous Coronary Intervention Versus Coronary Artery 
      Bypass Grafting for Patients with Type 2 Diabetes Mellitus Suffering from Left 
      Main Coronary Disease: A Meta-Analysis.
PG  - 1041-1054
LID - 10.1007/s13300-021-01025-x [doi]
AB  - INTRODUCTION: In this meta-analysis, we aimed to systematically compare the 
      10-year outcomes of percutaneous coronary intervention (PCI) versus coronary 
      artery bypass grafting (CABG) in patients with type 2 diabetes mellitus (T2DM) 
      suffering from left main coronary artery disease (LMCD). METHODS: Medical 
      Literature Analysis and Retrieval System Online (MEDLINE), 
      http://www.ClinicalTrials.gov , Excerpta Medica dataBASE (EMBASE), Cochrane 
      Central, Web of Science, and Google scholar were searched for publications 
      comparing 10-year outcomes of PCI versus CABG in patients with T2DM suffering 
      from LMCD. Cardiovascular outcomes were considered as the clinical endpoints. 
      Statistical analysis was carried out using RevMan software (version 5.4). Risk 
      ratios (RR) with 95% confidence intervals (CI) were used to represent the data 
      after analysis. RESULTS: Eight studies (three randomized trials and five 
      observational studies) with a total number of 3835 participants with T2DM were 
      included in this analysis; 2340 participants were assigned to the PCI group and 
      1495 participants were assigned to the CABG group. Results of this analysis 
      showed that mortality (RR 0.85, 95% CI 0.73-1.00; P = 0.05), myocardial 
      infarction (RR 0.53, 95% CI 0.35-0.80; P = 0.002), repeated revascularization (RR 
      0.34, 95% CI 0.26-0.46; P = 0.00001), and target vessel revascularization (RR 
      0.26, 95% CI 0.18-0.38; P = 0.00001) were significantly higher with PCI when 
      compared to CABG in these patients with diabetes and LMCD. Major adverse cardiac 
      and cerebrovascular events were also significantly higher with PCI at 10 years 
      (RR 0.67, 95% CI 0.49-0.92; P = 0.01). However, CABG was associated with a 
      significantly higher risk of stroke (RR 2.16, 95% CI 1.39-3.37; P = 0.0007). 
      CONCLUSIONS: During a long-term follow-up time period of 10 years, PCI was 
      associated with worse clinical outcomes compared to CABG in these patients with 
      T2DM suffering from LMCD. However, a significantly higher risk of stroke was 
      observed with CABG. This piece of information might be vital in order to 
      carefully choose and prevent complications following revascularization in such 
      patients.
FAU - Wang, Hong
AU  - Wang H
AD  - Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, 530021, Guangxi, People's Republic of China. iriswh2014@163.com.
FAU - Wang, Hongli
AU  - Wang H
AD  - Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, 530021, Guangxi, People's Republic of China.
FAU - Wei, Yuyuan
AU  - Wei Y
AD  - Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, 530021, Guangxi, People's Republic of China.
FAU - Li, Xinxin
AU  - Li X
AD  - Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, 530021, Guangxi, People's Republic of China.
FAU - Jhummun, Vineet
AU  - Jhummun V
AD  - Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
FAU - Ahmed, Mohamad A
AU  - Ahmed MA
AD  - Department of Cardiology, Peking University People's Hospital, Beijing, People's 
      Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20210227
PL  - United States
TA  - Diabetes Ther
JT  - Diabetes therapy : research, treatment and education of diabetes and related 
      disorders
JID - 101539025
PMC - PMC7994472
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - Coronary artery bypass grafting
OT  - Left main coronary disease
OT  - Long-term outcomes
OT  - Percutaneous coronary intervention
OT  - Revascularization therapies
OT  - Type 2 diabetes mellitus
EDAT- 2021/03/01 06:00
MHDA- 2021/03/01 06:01
PMCR- 2021/02/27
CRDT- 2021/02/28 20:40
PHST- 2020/12/25 00:00 [received]
PHST- 2021/02/08 00:00 [accepted]
PHST- 2021/03/01 06:00 [pubmed]
PHST- 2021/03/01 06:01 [medline]
PHST- 2021/02/28 20:40 [entrez]
PHST- 2021/02/27 00:00 [pmc-release]
AID - 10.1007/s13300-021-01025-x [pii]
AID - 1025 [pii]
AID - 10.1007/s13300-021-01025-x [doi]
PST - ppublish
SO  - Diabetes Ther. 2021 Apr;12(4):1041-1054. doi: 10.1007/s13300-021-01025-x. Epub 
      2021 Feb 27.