PMID- 33641496
OWN - NLM
STAT- MEDLINE
DCOM- 20211027
LR  - 20220402
IS  - 2385-2011 (Electronic)
IS  - 1591-0199 (Print)
IS  - 1591-0199 (Linking)
VI  - 27
IP  - 2
DP  - 2021 Apr
TI  - Hemodynamic effects of intracranial aneurysms from stent-induced straightening of 
      parent vessels by stent-assisted coiling embolization.
PG  - 181-190
LID - 10.1177/1591019921995334 [doi]
AB  - BACKGROUND: Straightening of parent vessels happens for stent-assisted coiling 
      embolization (SACE) treatment of intracranial aneurysms. This study aims to 
      investigate aneurysmal hemodynamic modifications caused by stent-induced vessel 
      straightening. METHODS: Stent and coil deployments of a SACE-treated distal 
      bifurcation aneurysm by finite element method were performed first with the 
      preoperative (not straightened, NS) and postoperative (straightened, S) vessel 
      models respectively. Computational fluid dynamics were then performed for eight 
      models, including (I) NS only model, (II) NS+stent model, (III) NS+coils model, 
      (IV) NS+stent+coils model, (V) S only model, (VI) S+stent model, (VII) S+coils 
      model, and (VIII) S+stent+coils model. Finally, changes in aneurysmal flow 
      velocity, isovelocity surface and wall shear stress (WSS) were analyzed 
      qualitatively and quantitatively. RESULTS: The flow was less in the S models than 
      that in the corresponding NS models. Coils blocked most of the flow into the 
      aneurysm sac in both NS models and S models and vessel straightening had more 
      profound effect on the high aneurysmal flow volume reduction than coiling, while 
      stenting generated adverse effect on flow reduction. Taking the NS only model as 
      baseline (100%), the sac-averaged velocities of models II to VIII were 112%, 36%, 
      42%, 45%, 39%, 12%, 13%, and high flow volumes were 119%, 21%, 30%, 10%, 8%, 3%, 
      3%, while the sac-averaged WSSs were 106%, 37%, 44%, 41%, 35%, 17% and 24%, 
      respectively. CONCLUSIONS: Stent-induced vessel straightening combined coil 
      embolization has the best performance in hemodynamic modifications and may reduce 
      the recurrence rate, whereas stenting may generate adverse effect on hemodynamic 
      alterations.
FAU - Leng, Xiaochang
AU  - Leng X
AUID- ORCID: 0000-0002-0041-7602
AD  - ArteryFlow Technology Co., Ltd., Hangzhou, China.
AD  - School of Civil Engineering and Architecture, Nanchang University, Nanchang, 
      China.
FAU - Wan, Hailin
AU  - Wan H
AUID- ORCID: 0000-0001-6761-4603
AD  - Department of Radiology, Huashan Hospital Affiliated to Fudan University, 
      Shanghai, China.
FAU - Li, Gaohui
AU  - Li G
AD  - ArteryFlow Technology Co., Ltd., Hangzhou, China.
FAU - Jiang, Yeqing
AU  - Jiang Y
AUID- ORCID: 0000-0001-7558-917X
AD  - Department of Radiology, Huashan Hospital Affiliated to Fudan University, 
      Shanghai, China.
FAU - Huang, Lei
AU  - Huang L
AD  - Department of Radiology, Huashan Hospital Affiliated to Fudan University, 
      Shanghai, China.
FAU - Siddiqui, Adnan H
AU  - Siddiqui AH
AD  - Department of Neurosurgery and Radiology, University at Buffalo, The State 
      University of New York, Buffalo, NY, USA.
FAU - Zhang, Xiaolong
AU  - Zhang X
AD  - Department of Radiology, Huashan Hospital Affiliated to Fudan University, 
      Shanghai, China.
FAU - Xiang, Jianping
AU  - Xiang J
AD  - ArteryFlow Technology Co., Ltd., Hangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20210227
PL  - United States
TA  - Interv Neuroradiol
JT  - Interventional neuroradiology : journal of peritherapeutic neuroradiology, 
      surgical procedures and related neurosciences
JID - 9602695
SB  - IM
MH  - Blood Vessel Prosthesis
MH  - *Embolization, Therapeutic
MH  - Hemodynamics
MH  - Humans
MH  - Hydrodynamics
MH  - *Intracranial Aneurysm/diagnostic imaging/therapy
MH  - Stents
MH  - Treatment Outcome
PMC - PMC8050531
OTO - NOTNLM
OT  - Intracranial aneurysm
OT  - computational fluid dynamics
OT  - finite element analysis
OT  - hemodynamics
OT  - stent-assisted coiling embolization
OT  - straightening
COIS- Declaration of conflicting interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2021/03/02 06:00
MHDA- 2021/10/28 06:00
PMCR- 2022/04/01
CRDT- 2021/03/01 05:24
PHST- 2021/03/02 06:00 [pubmed]
PHST- 2021/10/28 06:00 [medline]
PHST- 2021/03/01 05:24 [entrez]
PHST- 2022/04/01 00:00 [pmc-release]
AID - 10.1177_1591019921995334 [pii]
AID - 10.1177/1591019921995334 [doi]
PST - ppublish
SO  - Interv Neuroradiol. 2021 Apr;27(2):181-190. doi: 10.1177/1591019921995334. Epub 
      2021 Feb 27.