PMID- 33642232
OWN - NLM
STAT- MEDLINE
DCOM- 20211026
LR  - 20211026
IS  - 2212-5353 (Electronic)
IS  - 2212-5345 (Linking)
VI  - 59
IP  - 4
DP  - 2021 Jul
TI  - Association between low mean corpuscular hemoglobin and prognosis in patients 
      with exacerbation of chronic obstructive pulmonary disease.
PG  - 498-504
LID - S2212-5345(21)00031-9 [pii]
LID - 10.1016/j.resinv.2021.01.006 [doi]
AB  - BACKGROUND: Several studies have demonstrated the association between mean 
      corpuscular hemoglobin concentration (MCHC), a hematological index used for the 
      assessment of anemia, and the prognosis of patients with heart disease. While the 
      red cell distribution width (RDW) is known to be related to the prognosis of 
      patients with chronic obstructive pulmonary disease (COPD), few studies have 
      focused on the association between the MCHC and COPD. Therefore, we examined the 
      association between the MCHC and prognosis in patients with exacerbation of COPD. 
      METHODS: We examined the association between the 30-day mortality and clinical 
      findings in patients with COPD exacerbation who were hospitalized between October 
      2008 and December 2018. RESULTS: We enrolled 195 patients with COPD exacerbation 
      (average age: 76.4 years; 181 men, 14 women). The MCHC was significantly lower, 
      while the RDW was significantly higher in the 27 patients (13.8%) who died during 
      the 30-day observation period compared to those in the patients who survived. 
      Multivariate logistic regression analysis revealed that the MCHC was 
      independently associated with 30-day mortality. The area under the curve 
      calculated from the MCHC obtained from peripheral blood was 0.688 and the cutoff 
      value was 31.6 g/dL, with a sensitivity of 0.593 and specificity of 0.810 
      (p = 0.0001). CONCLUSION: The MCHC might be a valuable biomarker for evaluating 
      the prognosis of patients with COPD exacerbation.
CI  - Copyright (c) 2021 The Japanese Respiratory Society. Published by Elsevier B.V. All 
      rights reserved.
FAU - Sato, Kento
AU  - Sato K
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University 
      Faculty of Medicine, Yamagata, Japan.
FAU - Inoue, Sumito
AU  - Inoue S
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University 
      Faculty of Medicine, Yamagata, Japan. Electronic address: 
      sinoue@med.id.yamagata-u.ac.jp.
FAU - Ishibashi, Yu
AU  - Ishibashi Y
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University 
      Faculty of Medicine, Yamagata, Japan.
FAU - Ota, Takahito
AU  - Ota T
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University 
      Faculty of Medicine, Yamagata, Japan.
FAU - Murano, Hiroaki
AU  - Murano H
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University 
      Faculty of Medicine, Yamagata, Japan.
FAU - Furuyama, Kodai
AU  - Furuyama K
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University 
      Faculty of Medicine, Yamagata, Japan.
FAU - Yang, Sujeong
AU  - Yang S
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University 
      Faculty of Medicine, Yamagata, Japan.
FAU - Machida, Hiroyoshi
AU  - Machida H
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University 
      Faculty of Medicine, Yamagata, Japan.
FAU - Nakano, Hiroshi
AU  - Nakano H
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University 
      Faculty of Medicine, Yamagata, Japan.
FAU - Sato, Masamichi
AU  - Sato M
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University 
      Faculty of Medicine, Yamagata, Japan.
FAU - Nemoto, Takako
AU  - Nemoto T
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University 
      Faculty of Medicine, Yamagata, Japan.
FAU - Nishiwaki, Michiko
AU  - Nishiwaki M
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University 
      Faculty of Medicine, Yamagata, Japan.
FAU - Yamauchi, Keiko
AU  - Yamauchi K
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University 
      Faculty of Medicine, Yamagata, Japan.
FAU - Igarashi, Akira
AU  - Igarashi A
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University 
      Faculty of Medicine, Yamagata, Japan.
FAU - Watanabe, Masafumi
AU  - Watanabe M
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University 
      Faculty of Medicine, Yamagata, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210226
PL  - Netherlands
TA  - Respir Investig
JT  - Respiratory investigation
JID - 101581124
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aged
MH  - *Anemia
MH  - Biomarkers
MH  - Erythrocyte Indices
MH  - Female
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - *Pulmonary Disease, Chronic Obstructive/diagnosis
OTO - NOTNLM
OT  - Chronic obstructive pulmonary disease
OT  - Exacerbation
OT  - Mean corpuscular hemoglobin concentration
OT  - Prognosis
OT  - Red cell distribution width
COIS- Conflict of Interest The authors have no conflict of interest to declare.
EDAT- 2021/03/02 06:00
MHDA- 2021/10/27 06:00
CRDT- 2021/03/01 05:32
PHST- 2020/12/03 00:00 [received]
PHST- 2021/01/20 00:00 [revised]
PHST- 2021/01/29 00:00 [accepted]
PHST- 2021/03/02 06:00 [pubmed]
PHST- 2021/10/27 06:00 [medline]
PHST- 2021/03/01 05:32 [entrez]
AID - S2212-5345(21)00031-9 [pii]
AID - 10.1016/j.resinv.2021.01.006 [doi]
PST - ppublish
SO  - Respir Investig. 2021 Jul;59(4):498-504. doi: 10.1016/j.resinv.2021.01.006. Epub 
      2021 Feb 26.