PMID- 33642492
OWN - NLM
STAT- MEDLINE
DCOM- 20210917
LR  - 20210917
IS  - 1881-784X (Electronic)
IS  - 1881-7831 (Linking)
VI  - 15
IP  - 1
DP  - 2021 Mar 10
TI  - The safety of ritodrine hydrochloride: Adverse effects on fetuses and newborns.
PG  - 14-19
LID - 10.5582/ddt.2021.01016 [doi]
AB  - Prematurely born infants face unique risks, and the treatment of imminent preterm 
      birth is thus an important part of perinatal care. Ritodrine hydrochloride (Rito) 
      is widely used as a therapeutic agent to treat imminent preterm birth in Japan. 
      Following assessment of the risks and benefits of short-acting beta-agonists, 
      including Rito, in Europe, however, the use of Rito has begun to be questioned. 
      Thus, in this study we investigated the safety of Rito in the treatment of 
      imminent preterm birth, with a particular focus on the adverse effects (AEs) on 
      fetuses and newborn infants. Using the Pharmaceuticals and Medical Devices Agency 
      of Japan's Japanese Adverse Drug Event Report (JADER) database, the AEs on 
      fetuses and newborns caused by oral and injected Rito were extracted and 
      analyzed. The reported odds ratios for oral Rito were significantly higher for 
      fetal tachycardia, fetal bradycardia, neonatal hypoglycemia, and neonatal heart 
      failure than for other drugs. The reported odds ratios for Rito injection were 
      significantly higher for fetal tachycardia and neonatal hypoglycemia than for 
      other drugs. Oral drugs had more adverse effect reports than injectable drugs.
FAU - Yonaga, Yuriko
AU  - Yonaga Y
AD  - Department of Pharmaceutical Sciences, Teikyo Heisei University, Nakano, Tokyo, 
      Japan.
FAU - Ito, Akihiko
AU  - Ito A
AD  - Department of Pharmaceutical Sciences, Teikyo Heisei University, Nakano, Tokyo, 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20210227
PL  - Japan
TA  - Drug Discov Ther
JT  - Drug discoveries & therapeutics
JID - 101493809
RN  - 0 (Tocolytic Agents)
RN  - I0Q6O6740J (Ritodrine)
SB  - IM
RIN - Drug Discov Ther. 2021;15(2):E1. PMID: 34011822
MH  - Administration, Oral
MH  - Adolescent
MH  - Adult
MH  - Adverse Drug Reaction Reporting Systems
MH  - Drug-Related Side Effects and Adverse Reactions/*etiology
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Injections, Intramuscular
MH  - Japan
MH  - Pregnancy
MH  - Premature Birth/*prevention & control
MH  - Ritodrine/*administration & dosage/adverse effects
MH  - Tocolytic Agents/*administration & dosage/adverse effects
MH  - Young Adult
OTO - NOTNLM
OT  - Ritodrine hydrochloride
OT  - adverse effects
OT  - fetuses
OT  - newborns
OT  - pregnant women
EDAT- 2021/03/02 06:00
MHDA- 2021/03/02 06:01
CRDT- 2021/03/01 05:33
PHST- 2021/03/02 06:00 [pubmed]
PHST- 2021/03/02 06:01 [medline]
PHST- 2021/03/01 05:33 [entrez]
AID - 10.5582/ddt.2021.01016 [doi]
PST - ppublish
SO  - Drug Discov Ther. 2021 Mar 10;15(1):14-19. doi: 10.5582/ddt.2021.01016. Epub 2021 
      Feb 27.