PMID- 33642550
OWN - NLM
STAT- MEDLINE
DCOM- 20211014
LR  - 20211014
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 44
IP  - 3
DP  - 2021
TI  - Glucosyl Hesperidin Has an Anti-diabetic Effect in High-Fat Diet-Induced Obese 
      Mice.
PG  - 422-430
LID - 10.1248/bpb.b20-00849 [doi]
AB  - Glucosyl hesperidin (GH) is a water-soluble derivative of hesperidin, a citrus 
      flavonoid. GH has various pharmacological effects, such as hypolipidemic and 
      hypouricemic effects, and may therefore be a useful supplement or drug. In the 
      present study, we evaluated the effects of long- and short-term intake of GH on 
      hyperglycemia and macrophage infiltration into the adipose tissue of high-fat 
      diet (HFD)-fed mice. Long-term (11-week) consumption of GH tended to reduce body 
      weight and the fasting blood glucose concentration of the HFD-fed mice, and 
      ameliorated glucose intolerance and insulin resistance, according to glucose and 
      insulin tolerance tests. Additionally, although GH did not affect fat pad weight, 
      it reduced HFD-induced macrophage infiltration into adipose tissue. Short-term 
      (2-week) consumption of GH did not affect the HFD-induced increases in body 
      weight or fasting blood glucose, and it did not ameliorate glucose intolerance or 
      insulin resistance. However, short-term intake did reduce the HFD-induced 
      macrophage infiltration and monocyte chemotactic protein 1 (MCP-1) expression in 
      adipose tissue. Furthermore, hesperetin, which is an aglycone of GH, inhibited 
      MCP-1 expression in 3T3-L1 adipocytes, 3T3-L1 adipocytes co-cultured with RAW264 
      macrophages, and tumor necrosis factor-alpha-treated 3T3-L1 adipocytes. The present 
      findings suggest that daily consumption of GH may have preventive and/or 
      therapeutic effects on obesity-related diseases, such as diabetes mellitus.
FAU - Yoshida, Hiroki
AU  - Yoshida H
AD  - Department of Biochemistry, Graduate School of Clinical Pharmacy, Kyushu 
      University of Health and Welfare.
FAU - Tsuhako, Rika
AU  - Tsuhako R
AD  - Department of Biochemistry, Graduate School of Clinical Pharmacy, Kyushu 
      University of Health and Welfare.
FAU - Sugita, Chihiro
AU  - Sugita C
AD  - Department of Biochemistry, Graduate School of Clinical Pharmacy, Kyushu 
      University of Health and Welfare.
FAU - Kurokawa, Masahiko
AU  - Kurokawa M
AD  - Department of Biochemistry, Graduate School of Clinical Pharmacy, Kyushu 
      University of Health and Welfare.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Glucosides)
RN  - 0 (Hypoglycemic Agents)
RN  - 432C95B6YE (glucosyl hesperidin)
RN  - E750O06Y6O (Hesperidin)
SB  - IM
MH  - 3T3-L1 Cells
MH  - Adipose Tissue/drug effects/immunology
MH  - Animals
MH  - Chemokine CCL2/genetics/immunology
MH  - Coculture Techniques
MH  - Diet, High-Fat
MH  - Disease Models, Animal
MH  - Glucosides/pharmacology/*therapeutic use
MH  - Hesperidin/*analogs & derivatives/pharmacology/therapeutic use
MH  - Hyperglycemia/*drug therapy/immunology
MH  - Hypoglycemic Agents/pharmacology/*therapeutic use
MH  - Macrophages/drug effects/immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Obesity/*drug therapy/immunology
MH  - RAW 264.7 Cells
OTO - NOTNLM
OT  - adipocyte
OT  - diabetes
OT  - flavonoid
OT  - macrophage
EDAT- 2021/03/02 06:00
MHDA- 2021/10/15 06:00
CRDT- 2021/03/01 05:33
PHST- 2021/03/01 05:33 [entrez]
PHST- 2021/03/02 06:00 [pubmed]
PHST- 2021/10/15 06:00 [medline]
AID - 10.1248/bpb.b20-00849 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2021;44(3):422-430. doi: 10.1248/bpb.b20-00849.