PMID- 33642833
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 27
IP  - 7
DP  - 2021 Feb 21
TI  - Clinicopathological features and prognostic factors associated with 
      gastroenteropancreatic mixed neuroendocrine non-neuroendocrine neoplasms in 
      Chinese patients.
PG  - 624-640
LID - 10.3748/wjg.v27.i7.624 [doi]
AB  - BACKGROUND: The incidence of mixed neuroendocrine-non-neuroendocrine neoplasms 
      (MiNEN) is low. To improve our understanding of this rare tumor type and 
      optimally guide clinical treatment, associated risk factors, clinical 
      manifestations, and prognosis must be explored. AIM: To identify risk factors 
      that influence the prognosis of patients with gastroenteropancreatic MiNEN 
      (GEP-MiNEN). METHODS: We retrospectively analyzed the clinical data of 46 
      patients who were diagnosed with GEP-MiNEN at the First Affiliated Hospital of 
      Bengbu Medical College (Anhui, China) between January 2013 and December 2017. 
      Risk factors influencing the prognosis of the patients were assessed using 
      Kaplan-Meier curves and cox regression models. We compared the results with 55 
      randomly selected patients with gastroenteropancreatic GEP neuroendocrine tumors, 
      47 with neuroendocrine carcinomas (NEC), and 58 with poorly differentiated 
      adenocarcinoma. RESULTS: Among the 46 patients with GEP-MiNEN, thirty-five had 
      gastric tumors, nine had intestinal tumors (four in the small intestine and five 
      in the colon and rectum), and two had pancreatic tumors. The median age of the 
      patients was 66 (41-84) years, and the male-to-female ratio was 2.83. 
      Thirty-three (71.7%) patients had clinical stage III and IV cancers. Distant 
      metastasis occurred in 14 patients, of which 13 had metastasis to the liver. The 
      follow-up period was 11-72 mo, and the median overall survival was 30 mo. Ki-67 
      index >/= 50%, high proportion of NEC, lymph node involvement, distant metastasis, 
      and higher clinical stage were independent risk factors affecting the prognosis 
      of patients with GEP-MiNEN. The median overall survival was shorter for patients 
      with NEC than for those with MiNEN (14 mo vs 30 mo, P = 0.001), but did not 
      significantly differ from those with poorly differentiated adenocarcinoma and 
      MiNEN (30 mo vs 18 mo, P = 0.453). CONCLUSION: A poor prognosis is associated 
      with rare, aggressive GEP-MiNEN. Ki-67 index, tumor composition, lymph node 
      involvement, distant metastasis, and clinical stage are important factors for 
      patient prognosis.
CI  - (c)The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Huang, Yu-Chen
AU  - Huang YC
AD  - Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, 
      Bengbu 233000, Anhui Province, China.
FAU - Yang, Ning-Ning
AU  - Yang NN
AD  - Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, 
      Bengbu 233000, Anhui Province, China.
FAU - Chen, Hong-Chun
AU  - Chen HC
AD  - Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, 
      Bengbu 233000, Anhui Province, China.
FAU - Huang, Yuan-Li
AU  - Huang YL
AD  - Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, 
      Bengbu 233000, Anhui Province, China.
FAU - Yan, Wen-Tian
AU  - Yan WT
AD  - Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, 
      Bengbu 233000, Anhui Province, China.
FAU - Yang, Ru-Xue
AU  - Yang RX
AD  - Department of Pathology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei 230000, Anhui Province, China.
FAU - Li, Nan
AU  - Li N
AD  - Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, 
      Bengbu 233000, Anhui Province, China.
FAU - Zhang, Shan
AU  - Zhang S
AD  - Department of Pathology, The Second People's Hospital of Hefei, Hefei 230000, 
      Anhui Province, China.
FAU - Yang, Pan-Pan
AU  - Yang PP
AD  - Department of Pathology, The Second Affiliated Hospital of Anhui Medical 
      University, Hefei 230000, Anhui Province, China.
FAU - Feng, Zhen-Zhong
AU  - Feng ZZ
AD  - Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, 
      Bengbu 233000, Anhui Province, China. fzz18297301626@163.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Carcinoma, Neuroendocrine
MH  - China/epidemiology
MH  - Female
MH  - Humans
MH  - *Intestinal Neoplasms/epidemiology/therapy
MH  - Male
MH  - *Neuroendocrine Tumors/epidemiology/therapy
MH  - *Pancreatic Neoplasms/epidemiology
MH  - Prognosis
MH  - Retrospective Studies
MH  - *Stomach Neoplasms/epidemiology/therapy
PMC - PMC7901054
OTO - NOTNLM
OT  - Gastro-entero-pancreatic tract
OT  - Mixed adenoneuro-endocrine carcinoma
OT  - Mixed neuroendocrine non-neuroendocrine neoplasm
OT  - Prognosis
COIS- Conflict-of-interest statement: We have no financial relationships to disclose.
EDAT- 2021/03/02 06:00
MHDA- 2021/05/15 06:00
PMCR- 2021/02/21
CRDT- 2021/03/01 05:34
PHST- 2020/11/15 00:00 [received]
PHST- 2020/12/24 00:00 [revised]
PHST- 2021/01/13 00:00 [accepted]
PHST- 2021/03/01 05:34 [entrez]
PHST- 2021/03/02 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2021/02/21 00:00 [pmc-release]
AID - 10.3748/wjg.v27.i7.624 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2021 Feb 21;27(7):624-640. doi: 10.3748/wjg.v27.i7.624.