PMID- 33643189
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210303
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 12
DP  - 2021
TI  - The Effect on the Kidney in Patients With Anti-N-methyl D-aspartate Receptor 
      Antibody Encephalitis.
PG  - 601495
LID - 10.3389/fneur.2021.601495 [doi]
LID - 601495
AB  - Objectives: The function of the N-methyl-D-aspartate receptor (NMDAR) in the 
      kidney has been studied. However, the effect on the kidney from anti-NAMDAR 
      antibody encephalitis has not been investigated thus far. Methods: Case data were 
      collected from 82 patients with anti-NMDAR antibody encephalitis and 166 age- and 
      sex-matched healthy controls (HCs). Clinical characteristics, urinalysis 
      [including urine pH and urine specific gravity (SG)], serum creatinine (Scr), and 
      estimated glomerular filtration rate (eGFR) based on Cr levels were evaluated. 
      Results: At initial admission, urine pH levels and urine SG levels in anti-NMDAR 
      antibody encephalitis patients were significantly higher and lower, respectively, 
      than HCs (both p < 0.001). There were no significant differences in Scr and eGFR 
      between anti-NMDAR antibody encephalitis patients and HCs. Urine pH levels in 
      patients with anti-NMDAR antibody <1:32 were significantly lower than those in 
      patients with anti-NMDAR antibody >/=1:32 (p = 0.029). Urine pH levels were 
      significantly lower (p = 0.004) and urine SG levels were significantly higher (p 
      = 0.027) in a follow-up evaluation 3 months after treatment. Conclusions: The 
      changes in urinalysis occur in patients with anti-NMDAR antibody encephalitis. 
      The pathophysiological changes in anti-NMDAR antibody encephalitis were not 
      limited to the CNS.
CI  - Copyright (c) 2021 Liu, Gu, Liu, Liu, Xu, Fan, Peng and Jiang.
FAU - Liu, Lizhi
AU  - Liu L
AD  - Department of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
AD  - Department of Neurology, Huizhou Hospital of Traditional Chinese Medicine, 
      Huizhou, China.
FAU - Gu, Meifeng
AU  - Gu M
AD  - Department of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Liu, Jia
AU  - Liu J
AD  - Department of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Liu, Qing
AU  - Liu Q
AD  - Department of Neurology, Huizhou Hospital of Traditional Chinese Medicine, 
      Huizhou, China.
FAU - Xu, Xiaofeng
AU  - Xu X
AD  - Department of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Fan, Rong
AU  - Fan R
AD  - Department of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Peng, Fuhua
AU  - Peng F
AD  - Department of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Jiang, Ying
AU  - Jiang Y
AD  - Department of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20210212
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC7907499
OTO - NOTNLM
OT  - anti-N-methyl-D-aspartate receptor encephalitis
OT  - estimated glomerular filtration rate (eGFR)
OT  - renal function
OT  - urinalysis
OT  - urine pH
OT  - urine specific gravity (USG)
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/03/02 06:00
MHDA- 2021/03/02 06:01
PMCR- 2021/02/12
CRDT- 2021/03/01 05:36
PHST- 2020/09/01 00:00 [received]
PHST- 2021/01/15 00:00 [accepted]
PHST- 2021/03/01 05:36 [entrez]
PHST- 2021/03/02 06:00 [pubmed]
PHST- 2021/03/02 06:01 [medline]
PHST- 2021/02/12 00:00 [pmc-release]
AID - 10.3389/fneur.2021.601495 [doi]
PST - epublish
SO  - Front Neurol. 2021 Feb 12;12:601495. doi: 10.3389/fneur.2021.601495. eCollection 
      2021.