PMID- 33644990
OWN - NLM
STAT- MEDLINE
DCOM- 20220105
LR  - 20220105
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 13
IP  - 9
DP  - 2021 Sep
TI  - Association of metabolic score for insulin resistance and its 6-year change with 
      incident type 2 diabetes mellitus.
PG  - 725-734
LID - 10.1111/1753-0407.13161 [doi]
AB  - BACKGROUND: The evidence for the association between metabolic score for insulin 
      resistance (METS-IR) and type 2 diabetes mellitus (T2DM) is limited. We aimed to 
      explore the association of METS-IR and its 6-year change with risk of incident 
      T2DM in a rural Chinese population. METHODS: We analyzed data for 12 107 
      participants (mean age 50.48 years). A Cox proportional-hazard model was used to 
      estimate the association of METS-IR with incident T2DM by using hazard ratios 
      (HRs) and 95% confidence intervals (CIs); a logistic regression model was used to 
      assess the association of 6-year METS-IR change with incident T2DM by using odds 
      ratios (ORs) and 95% CIs. We used subgroup analyses of the association of METS-IR 
      and its 6-year change with incident T2DM by sex, age, and baseline fasting plasma 
      glucose (FPG) level as well as restricted cubic splines to describe the 
      dose-response association. RESULTS: The association of METS-IR and 6-year METS-IR 
      change with incident T2DM was significant (per SD unit increase: HR = 1.80, 95% 
      CI: 1.60-2.02 for METS-IR, OR = 1.42, 95% CI: 1.28-1.57 and OR = 1.59, 95% CI: 
      1.44-1.76 for relative and absolute METS-IR change). The significant association 
      remained on subgroup analyses by sex, age, and baseline FPG level. Dose-response 
      analysis demonstrated that the probability of incident T2DM was significantly 
      increased with increasing METS-IR and 6-year METS-IR change. CONCLUSIONS: 
      Increased METS-IR and 6-year METS-IR change were positively associated with risk 
      of incident T2DM in a rural Chinese population. METS-IR may be a vital indicator 
      for identifying T2DM.
CI  - (c) 2021 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John 
      Wiley & Sons Australia, Ltd.
FAU - Zhang, Ming
AU  - Zhang M
AD  - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen 
      University, Shenzhen, China.
FAU - Liu, Dechen
AU  - Liu D
AD  - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen 
      University, Shenzhen, China.
FAU - Qin, Pei
AU  - Qin P
AUID- ORCID: 0000-0003-2303-0379
AD  - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen 
      University, Shenzhen, China.
FAU - Liu, Yu
AU  - Liu Y
AD  - Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of 
      Shenzhen University Health Science Center, Shenzhen, China.
FAU - Sun, Xizhuo
AU  - Sun X
AD  - Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of 
      Shenzhen University Health Science Center, Shenzhen, China.
FAU - Li, Honghui
AU  - Li H
AD  - Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of 
      Shenzhen University Health Science Center, Shenzhen, China.
FAU - Wu, Xiaoyan
AU  - Wu X
AD  - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen 
      University, Shenzhen, China.
AD  - Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of 
      Shenzhen University Health Science Center, Shenzhen, China.
FAU - Zhang, Yanyan
AU  - Zhang Y
AD  - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen 
      University, Shenzhen, China.
AD  - Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of 
      Shenzhen University Health Science Center, Shenzhen, China.
FAU - Han, Minghui
AU  - Han M
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, China.
FAU - Qie, Ranran
AU  - Qie R
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, China.
FAU - Huang, Shengbing
AU  - Huang S
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, China.
FAU - Li, Yang
AU  - Li Y
AD  - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen 
      University, Shenzhen, China.
AD  - Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of 
      Shenzhen University Health Science Center, Shenzhen, China.
FAU - Wu, Yuying
AU  - Wu Y
AD  - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen 
      University, Shenzhen, China.
AD  - Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of 
      Shenzhen University Health Science Center, Shenzhen, China.
FAU - Yang, Xingjin
AU  - Yang X
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, China.
FAU - Feng, Yifei
AU  - Feng Y
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, China.
FAU - Zhao, Yang
AU  - Zhao Y
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, China.
FAU - Hu, Dongsheng
AU  - Hu D
AUID- ORCID: 0000-0002-9998-8041
AD  - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen 
      University, Shenzhen, China.
AD  - Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of 
      Shenzhen University Health Science Center, Shenzhen, China.
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, China.
FAU - Hu, Fulan
AU  - Hu F
AUID- ORCID: 0000-0002-2386-1503
AD  - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen 
      University, Shenzhen, China.
LA  - eng
GR  - 81402752/National Natural Science Foundation of China/
GR  - 81673260/National Natural Science Foundation of China/
GR  - 2019A1515011183/Natural Science Foundation of Guangdong Province/
GR  - JCYJ20170412110537191/Science and Technology Development Foundation of Shenzhen/
GR  - JCYJ20190808145805515/Science and Technology Development Foundation of Shenzhen/
PT  - Journal Article
DEP - 20210228
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
SB  - IM
MH  - Adult
MH  - China
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Female
MH  - Humans
MH  - *Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Rural Population
OTO - NOTNLM
OT  - 2型糖尿病
OT  - dose-response
OT  - epidemiology
OT  - metabolic score for insulin resistance
OT  - type 2 diabetes mellitus
OT  - 剂量反应关系
OT  - 流行病学
OT  - 胰岛素抵抗代谢评分
EDAT- 2021/03/02 06:00
MHDA- 2022/01/06 06:00
CRDT- 2021/03/01 05:46
PHST- 2021/01/09 00:00 [revised]
PHST- 2020/06/15 00:00 [received]
PHST- 2021/01/23 00:00 [accepted]
PHST- 2021/03/02 06:00 [pubmed]
PHST- 2022/01/06 06:00 [medline]
PHST- 2021/03/01 05:46 [entrez]
AID - 10.1111/1753-0407.13161 [doi]
PST - ppublish
SO  - J Diabetes. 2021 Sep;13(9):725-734. doi: 10.1111/1753-0407.13161. Epub 2021 Feb 
      28.