PMID- 33645518
OWN - NLM
STAT- MEDLINE
DCOM- 20210302
LR  - 20231213
IS  - 2310-6972 (Print)
IS  - 2310-6905 (Linking)
VI  - 67
IP  - 1
DP  - 2021 Jan
TI  - [The role of nociceptin in opioid regulation of brain functions].
PG  - 5-16
LID - 10.18097/PBMC20216701005 [doi]
AB  - This review discusses our current knowledge on the nociceptin/orphanin (N/OFQ) 
      system regarding its role in regulation of brain functions. Nociceptin receptor 
      (NOPr) was identified in 1994 [Bunzow et al., 1994; Mollereau et al., 1994]. In 
      1995 a 17 amino acid endogenous peptide was found to be the high-affinity ligand 
      for the NOPr [Reinscheid et al., 1995]. N/OFQ has a broad spectrum of activity 
      and can act as on opioid-like as well as an anti-opioid peptide. Considering high 
      level of N/OFQ and NOPr mRNA expression in the limbic brain regions, the 
      N/OFQ/NOP system is suggested to be involved in regulation of emotions, resward, 
      pain sensitivity, stress responsibility, sexual behavior, aggression, drug abuse 
      and addiction. However it is still not well understood whether an increased 
      vulnerability to drugs of abuse may be associated with dysregulation of N/OFQ/NOP 
      system. Current review further highlights a need for further research on 
      N/OFQ/NOP system as it could have clinical utility for substance abuse, 
      depression, and anxiety pharmacotherapy.
FAU - Shamakina, I Yu
AU  - Shamakina IY
AD  - V.P. Serbsky National Medical Research Center on Psychiatry and Addiction, 
      Moscow, Russia.
FAU - Shagiakhmetov, F Sh
AU  - Shagiakhmetov FS
AD  - The Institute of General Pathology and Pathophysiology, Moscow, Russia.
FAU - Anokhin, P K
AU  - Anokhin PK
AD  - V.P. Serbsky National Medical Research Center on Psychiatry and Addiction, 
      Moscow, Russia.
FAU - Kohan, V S
AU  - Kohan VS
AD  - V.P. Serbsky National Medical Research Center on Psychiatry and Addiction, 
      Moscow, Russia.
FAU - Davidova, T V
AU  - Davidova TV
AD  - The Institute of General Pathology and Pathophysiology, Moscow, Russia.
LA  - rus
PT  - Journal Article
PT  - Review
TT  - Rol' notsitseptina v mekhanizmakh opioidnoi reguliatsii funktsii mozga.
PL  - Russia (Federation)
TA  - Biomed Khim
JT  - Biomeditsinskaia khimiia
JID - 101196966
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Opioid Peptides)
SB  - IM
MH  - *Analgesics, Opioid
MH  - Anxiety
MH  - Brain/metabolism
MH  - *Opioid Peptides/metabolism
MH  - Nociceptin
OTO - NOTNLM
OT  - addiction
OT  - brain
OT  - nociceptin
OT  - opioid peptides
OT  - pain
OT  - stress
EDAT- 2021/03/02 06:00
MHDA- 2021/03/03 06:00
CRDT- 2021/03/01 09:22
PHST- 2021/03/01 09:22 [entrez]
PHST- 2021/03/02 06:00 [pubmed]
PHST- 2021/03/03 06:00 [medline]
AID - 10.18097/PBMC20216701005 [doi]
PST - ppublish
SO  - Biomed Khim. 2021 Jan;67(1):5-16. doi: 10.18097/PBMC20216701005.