PMID- 33646351
OWN - NLM
STAT- MEDLINE
DCOM- 20210624
LR  - 20210624
IS  - 2366-0058 (Electronic)
VI  - 46
IP  - 7
DP  - 2021 Jul
TI  - Hepatic mosaic enhancement pattern correlates with increased inflammatory 
      activity and adverse therapeutic outcomes in patients with Crohn's disease.
PG  - 3149-3158
LID - 10.1007/s00261-021-02979-z [doi]
AB  - PURPOSE: This study aimed to evaluate the role of hepatic mosaic enhancement 
      pattern (HMEP) on computed tomography images in the disease activity and 
      therapeutic outcome of Crohn's Disease (CD). METHODS: Twenty-five CD patients 
      with HMEP comprised the HMEP group, and 25 CD patients without HMEP, who had a 
      similar onset age, sex, and disease course with those in the HMEP group, 
      comprised the non-HMEP group. No underlying liver/biliary disease was observed in 
      any of the patients. Clinical characteristics, laboratory test results, Lemann 
      index, and CD endoscopic index of severity (CDEIS) were compared between the 
      groups using the Student t-, Mann-Whitney U, Chi square, or Fisher's exact tests. 
      Patients received top-down, step-up, or traditional treatment during the 
      follow-up period. After the 1-year follow-up, therapeutic outcomes (active 
      inflammation [CDEIS > 3.5 if the endoscopic data were available, or C-reactive 
      protein level > 5 mg/L if the endoscopic data were unavailable] or remission) 
      were evaluated. RESULTS: The occurrence rate of fistulas/abscesses was higher in 
      the HMEP group (84%, 21/25) than in the non-HMEP group (48%, 12/25) with no 
      statistical significance (P = 0.056). The HMEP group showed a higher C-reactive 
      protein level (P = 0.001), erythrocyte sedimentation rate (P = 0.013), and blood 
      platelet count (P = 0.005). There was no significant difference in therapeutic 
      strategies between the groups (P = 0.509). The HMEP group showed a significantly 
      lower remission ratio after anti-inflammatory treatment than the non-HMEP group 
      (P = 0.045). CONCLUSIONS: HMEP was correlated with increased inflammatory 
      activity and adverse therapeutic outcomes in CD. This finding provided insights 
      regarding novel markers of CD diagnosis and treatment.
FAU - Shi, Li
AU  - Shi L
AD  - Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 
      58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.
AD  - Department of Radiology, The Third Affiliated Hospital of Guangzhou Medical 
      University, 63 Duobao Road, Guangzhou, 510150, People's Republic of China.
FAU - Lu, Bao-Lan
AU  - Lu BL
AD  - Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 
      58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.
FAU - Qiu, Yun
AU  - Qiu Y
AD  - Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen 
      University, 58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.
FAU - Huang, Li
AU  - Huang L
AD  - Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 
      58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.
FAU - Huang, Si-Yun
AU  - Huang SY
AD  - Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 
      58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.
FAU - Mao, Ren
AU  - Mao R
AD  - Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen 
      University, 58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.
FAU - Lin, Jin-Jiang
AU  - Lin JJ
AD  - Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 
      58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.
FAU - Du, Jin-Fang
AU  - Du JF
AD  - Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 
      58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.
FAU - Feng, Shi-Ting
AU  - Feng ST
AD  - Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 
      58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.
FAU - Li, Zi-Ping
AU  - Li ZP
AD  - Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 
      58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.
FAU - Sun, Can-Hui
AU  - Sun CH
AD  - Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 
      58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China. 
      sunch@mail.sysu.edu.cn.
FAU - Li, Xue-Hua
AU  - Li XH
AUID- ORCID: 0000-0003-3970-6871
AD  - Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 
      58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China. 
      lxueh@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210301
PL  - United States
TA  - Abdom Radiol (NY)
JT  - Abdominal radiology (New York)
JID - 101674571
SB  - IM
MH  - *Crohn Disease/diagnostic imaging/drug therapy
MH  - Disease Progression
MH  - Humans
MH  - Liver/diagnostic imaging
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Crohn's disease
OT  - Disease activity
OT  - Inflammation
OT  - Mosaic enhancement pattern
OT  - Therapy
EDAT- 2021/03/02 06:00
MHDA- 2021/06/25 06:00
CRDT- 2021/03/01 12:13
PHST- 2020/10/31 00:00 [received]
PHST- 2021/02/09 00:00 [accepted]
PHST- 2021/01/25 00:00 [revised]
PHST- 2021/03/02 06:00 [pubmed]
PHST- 2021/06/25 06:00 [medline]
PHST- 2021/03/01 12:13 [entrez]
AID - 10.1007/s00261-021-02979-z [pii]
AID - 10.1007/s00261-021-02979-z [doi]
PST - ppublish
SO  - Abdom Radiol (NY). 2021 Jul;46(7):3149-3158. doi: 10.1007/s00261-021-02979-z. 
      Epub 2021 Mar 1.