PMID- 33647713
OWN - NLM
STAT- MEDLINE
DCOM- 20220113
LR  - 20220113
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 141
DP  - 2021 May
TI  - Elevated interleukin-37 associated with tophus and pro-inflammatory mediators in 
      Chinese gout patients.
PG  - 155468
LID - S1043-4666(21)00048-X [pii]
LID - 10.1016/j.cyto.2021.155468 [doi]
AB  - INTRODUCTION: Interleukin-37(IL-37), a natural inhibitor of innate immunity, has 
      been identified to protect against various inflammatory diseases, including 
      monosodium urate (MSU)-induced inflammation. However, the association of IL-37 
      with clinical indexes and pro-inflammatory mediators in gout patients remains 
      unclear. The aim of this study was to determine IL-37 level in hyperuricemia and 
      gout patients with or without tophus, and to investigate the correlations of 
      IL-37 with clinical indexs such as Uric Acid (UA), CRP(C-reactive protein), 
      Creatinine Clearance Rate (Ccr), Erythrocyte Sedimentation Rate (ESR) and so on, 
      as well as with the pro-inflammatory mediators in serum including 
      Interleukin-1beta(IL-1beta), Interleukin-6(IL-6) and Interleukin-18(IL-18) from gout 
      patients. METHODOLOGY: The serum levels of IL-37, IL-1beta, IL-6 and IL-18 levels in 
      serum of gout patients were determined by ELISA; the correlations between IL-37 
      and clinical values or pro-inflammatory mediators in serum of gout were analyzed 
      by Spearman correlation test. RESULTS: The serum levels of IL-37 were higher in 
      active gout patients than inactive gout patients and HCs, especially in active 
      gout patients with tophus. No significant difference was observed in serum IL-37 
      levels between hyperuricemia and normal controls. IL-1beta, IL-6 and IL-18 levels 
      were significant elevated in gout patients with tophus than those without tophus; 
      Serum IL-37 were positively correlated with CRP and ESR, as well as with IL-1beta, 
      IL-6 and IL-18, negatively correlated with Ccr, and not correlated with UA, 
      creatinine (Cr) and triglyceride (TG) in gout patients. CONCLUSIONS: IL-37 
      increased in gout patients positively associated CRP and ESR, as well as with 
      proinflammatory mediators IL-1beta, IL-6, IL-18, the presence of tophus and chronic 
      kidney disease in gout. It may be a novel marker for predicting this pathology.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Ding, Liping
AU  - Ding L
AD  - Department of Rheumatology and Immunology, Shenzhen People's Hospital, The Second 
      Clinical Medical College of Jinan University, Shenzhen, China.
FAU - Li, Heng
AU  - Li H
AD  - Department of Rheumatology and Immunology, Shenzhen People's Hospital, The Second 
      Clinical Medical College of Jinan University, Shenzhen, China.
FAU - Sun, Baodong
AU  - Sun B
AD  - Department of Rheumatology and Immunology, Shenzhen People's Hospital, The Second 
      Clinical Medical College of Jinan University, Shenzhen, China.
FAU - Wang, Tingting
AU  - Wang T
AD  - Department of Rheumatology and Immunology, Shenzhen People's Hospital, The Second 
      Clinical Medical College of Jinan University, Shenzhen, China.
FAU - Meng, Shuhui
AU  - Meng S
AD  - Department of Rheumatology and Immunology, Shenzhen People's Hospital, The Second 
      Clinical Medical College of Jinan University, Shenzhen, China.
FAU - Huang, Qin
AU  - Huang Q
AD  - Department of Rheumatology and Immunology, Shenzhen People's Hospital, The Second 
      Clinical Medical College of Jinan University, Shenzhen, China.
FAU - Hong, Xiaoping
AU  - Hong X
AD  - Department of Rheumatology and Immunology, Shenzhen People's Hospital, The Second 
      Clinical Medical College of Jinan University, Shenzhen, China. Electronic 
      address: 123@tom.com.
FAU - Liu, Dongzhou
AU  - Liu D
AD  - Department of Rheumatology and Immunology, Shenzhen People's Hospital, The Second 
      Clinical Medical College of Jinan University, Shenzhen, China. Electronic 
      address: Liu_dz2001@sina.com.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210226
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (IL37 protein, human)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Gout/*blood/diagnostic imaging/immunology
MH  - Humans
MH  - Inflammation Mediators/*blood/immunology
MH  - Interleukin-1/*blood/immunology
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - IL-18
OT  - IL-1beta
OT  - IL-6
OT  - Interleukin-37
OT  - Tophus
EDAT- 2021/03/02 06:00
MHDA- 2022/01/14 06:00
CRDT- 2021/03/01 20:16
PHST- 2020/11/05 00:00 [received]
PHST- 2021/01/27 00:00 [revised]
PHST- 2021/02/03 00:00 [accepted]
PHST- 2021/03/02 06:00 [pubmed]
PHST- 2022/01/14 06:00 [medline]
PHST- 2021/03/01 20:16 [entrez]
AID - S1043-4666(21)00048-X [pii]
AID - 10.1016/j.cyto.2021.155468 [doi]
PST - ppublish
SO  - Cytokine. 2021 May;141:155468. doi: 10.1016/j.cyto.2021.155468. Epub 2021 Feb 26.