PMID- 33647821
OWN - NLM
STAT- MEDLINE
DCOM- 20211231
LR  - 20211231
IS  - 1532-3102 (Electronic)
IS  - 0143-4004 (Linking)
VI  - 106
DP  - 2021 Mar
TI  - Fetal exposure to environmental chemicals; insights from placental perfusion 
      studies.
PG  - 58-66
LID - S0143-4004(21)00033-3 [pii]
LID - 10.1016/j.placenta.2021.01.025 [doi]
AB  - INTRODUCTION: The burden of environmental chemicals in the human population is 
      ubiquitous and especially problematic in pregnancy due to potential exposure of 
      the vulnerable fetus. According to the Developmental Origins of Health and 
      Disease hypothesis, the fetal period is highly sensitive to exposure to 
      environmental factors that will determine the development of diseases later in 
      life. A range of environmental chemicals has been studied in the ex vivo 
      placental perfusion model, which is a human model using the intact placenta 
      directly after birth to study the placental transfer and metabolism of selected 
      compounds. METHODS: Here, we reviewed the existing knowledge on human placental 
      perfusion of environmental chemicals in order to identify potential correlations 
      between placental transfer and properties of chemicals and areas of future 
      research needs. RESULTS: We found 32 studies of the following groups of 
      environmental chemicals: pesticides, persistent organic pollutants (POPs), 
      plastics and byproducts, phyto/myco-estrogens and fungal toxins, byproducts from 
      heating/curing food, combustion in traffic and industry, and metals. The studies 
      showed highly distinct transfer rates from very fast transport to the fetal side 
      to negligible transfer. DISCUSSION: In general, a low molecular weight favors 
      placental translocation, but placental translocation is dependent on other 
      physicochemical properties of the substances, claiming the need for more 
      standardized studies and proper quantitative structure-activity relationship 
      (QSAR) analysis. Overall, we recommend using placental perfusion studies in the 
      risk assessment of environmental toxicants, to determine the transfer, metabolism 
      and toxic effects of this diverse class of substances, on the human term 
      placenta.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Mathiesen, Line
AU  - Mathiesen L
AD  - Department of Public Health, Section of Environmental Health, University of 
      Copenhagen, Oster Farimagsgade 5A, DK-1014, Copenhagen, Denmark. Electronic 
      address: lima@sund.ku.dk.
FAU - Buerki-Thurnherr, Tina
AU  - Buerki-Thurnherr T
AD  - Laboratory for Particles-Biology Interactions, Empa, Swiss Federal Laboratories 
      for Materials Science and Technology, St. Gallen, Switzerland.
FAU - Pastuschek, Jana
AU  - Pastuschek J
AD  - Placenta Lab, Department of Obstetrics, Jena University Hospital, Am Klinikum 1, 
      07747, Jena, Germany.
FAU - Aengenheister, Leonie
AU  - Aengenheister L
AD  - Laboratory for Particles-Biology Interactions, Empa, Swiss Federal Laboratories 
      for Materials Science and Technology, St. Gallen, Switzerland; Placenta Lab, 
      Department of Obstetrics, Jena University Hospital, Am Klinikum 1, 07747, Jena, 
      Germany.
FAU - Knudsen, Lisbeth E
AU  - Knudsen LE
AD  - Department of Public Health, Section of Environmental Health, University of 
      Copenhagen, Oster Farimagsgade 5A, DK-1014, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210213
PL  - Netherlands
TA  - Placenta
JT  - Placenta
JID - 8006349
RN  - 0 (Endocrine Disruptors)
SB  - IM
MH  - Animals
MH  - Endocrine Disruptors/*toxicity
MH  - *Environmental Exposure
MH  - Female
MH  - Humans
MH  - *Maternal Exposure
MH  - *Maternal-Fetal Exchange
MH  - Placenta/*drug effects/metabolism
MH  - Pregnancy
OTO - NOTNLM
OT  - Endocrine disruption
OT  - Environmental chemicals
OT  - Environmental toxicity
OT  - Fetal exposure
OT  - Maternal exposure
OT  - Placental barrier
OT  - Placental perfusion
EDAT- 2021/03/02 06:00
MHDA- 2022/01/01 06:00
CRDT- 2021/03/01 20:19
PHST- 2020/07/09 00:00 [received]
PHST- 2020/10/19 00:00 [revised]
PHST- 2021/01/22 00:00 [accepted]
PHST- 2021/03/02 06:00 [pubmed]
PHST- 2022/01/01 06:00 [medline]
PHST- 2021/03/01 20:19 [entrez]
AID - S0143-4004(21)00033-3 [pii]
AID - 10.1016/j.placenta.2021.01.025 [doi]
PST - ppublish
SO  - Placenta. 2021 Mar;106:58-66. doi: 10.1016/j.placenta.2021.01.025. Epub 2021 Feb 
      13.