PMID- 33648815
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20230511
IS  - 1096-3618 (Electronic)
IS  - 1044-5323 (Print)
IS  - 1044-5323 (Linking)
VI  - 51
DP  - 2021 Jan
TI  - HIV replication and latency in monocytes and macrophages.
PG  - 101472
LID - S1044-5323(21)00003-8 [pii]
LID - 10.1016/j.smim.2021.101472 [doi]
AB  - The relevance of monocyte and macrophage reservoirs in virally suppressed people 
      with HIV (vsPWH) has previously been debatable. Macrophages were assumed to have 
      a moderate life span and lack self-renewing potential. However, recent studies 
      have challenged this dogma and now suggest an important role of these cell as 
      long-lived HIV reservoirs. Lentiviruses have a long-documented association with 
      macrophages and abundant evidence exists that macrophages are important target 
      cells for HIV in vivo. A critical understanding of HIV infection, replication, 
      and latency in macrophages is needed in order to determine the appropriate method 
      of measuring and eliminating this cellular reservoir. This review provides a 
      brief discussion of the biology and acute and chronic infection of monocytes and 
      macrophages, with a more substantial focus on replication, latency and 
      measurement of the reservoir in cells of myeloid origin.
CI  - Copyright (c) 2021. Published by Elsevier Ltd.
FAU - Veenhuis, Rebecca T
AU  - Veenhuis RT
AD  - Department of Molecular and Comparative Biology, Johns Hopkins University School 
      of Medicine, Baltimore, MD, United States.
FAU - Abreu, Celina M
AU  - Abreu CM
AD  - Department of Molecular and Comparative Biology, Johns Hopkins University School 
      of Medicine, Baltimore, MD, United States.
FAU - Shirk, Erin N
AU  - Shirk EN
AD  - Department of Molecular and Comparative Biology, Johns Hopkins University School 
      of Medicine, Baltimore, MD, United States.
FAU - Gama, Lucio
AU  - Gama L
AD  - Department of Molecular and Comparative Biology, Johns Hopkins University School 
      of Medicine, Baltimore, MD, United States; Vaccine Research Center, NIAID, NIH, 
      Bethesda, MD, United States.
FAU - Clements, Janice E
AU  - Clements JE
AD  - Department of Molecular and Comparative Biology, Johns Hopkins University School 
      of Medicine, Baltimore, MD, United States; Department of Neurology, Johns Hopkins 
      University School of Medicine, Baltimore, MD, United States; Department of 
      Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United 
      States. Electronic address: jclements@jhmi.edu.
LA  - eng
GR  - U42 OD013117/OD/NIH HHS/United States
GR  - P01 AI131306/AI/NIAID NIH HHS/United States
GR  - P30 AI094189/AI/NIAID NIH HHS/United States
GR  - R01 NS089482/NS/NINDS NIH HHS/United States
GR  - P01 MH070306/MH/NIMH NIH HHS/United States
GR  - R01 DA050529/DA/NIDA NIH HHS/United States
GR  - R01 AI127142/AI/NIAID NIH HHS/United States
GR  - R01 NS077869/NS/NINDS NIH HHS/United States
GR  - R01 NS055651/NS/NINDS NIH HHS/United States
GR  - R56 AI118753/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20210227
PL  - England
TA  - Semin Immunol
JT  - Seminars in immunology
JID - 9009458
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes
MH  - *HIV Infections
MH  - Humans
MH  - Macrophages
MH  - Monocytes
MH  - *Simian Acquired Immunodeficiency Syndrome
MH  - *Simian Immunodeficiency Virus
MH  - Virus Replication
PMC - PMC10171083
MID - NIHMS1891451
OTO - NOTNLM
OT  - HIV
OT  - Latency
OT  - Macrophages
OT  - Replication
OT  - SIV
EDAT- 2021/03/03 06:00
MHDA- 2022/04/05 06:00
PMCR- 2023/05/10
CRDT- 2021/03/02 05:49
PHST- 2021/02/12 00:00 [received]
PHST- 2021/02/20 00:00 [accepted]
PHST- 2021/03/03 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2021/03/02 05:49 [entrez]
PHST- 2023/05/10 00:00 [pmc-release]
AID - S1044-5323(21)00003-8 [pii]
AID - 10.1016/j.smim.2021.101472 [doi]
PST - ppublish
SO  - Semin Immunol. 2021 Jan;51:101472. doi: 10.1016/j.smim.2021.101472. Epub 2021 Feb 
      27.