PMID- 33649891
OWN - NLM
STAT- MEDLINE
DCOM- 20210602
LR  - 20210915
IS  - 1432-5195 (Electronic)
IS  - 0341-2695 (Linking)
VI  - 45
IP  - 5
DP  - 2021 May
TI  - Two-year clinical outcomes of autologous microfragmented adipose tissue in 
      elderly patients with knee osteoarthritis: a multi-centric, international study.
PG  - 1179-1188
LID - 10.1007/s00264-021-04947-0 [doi]
AB  - PURPOSE: The aim of this study is to evaluate the outcomes of autologous 
      microfragmented adipose tissue (MFAT) injection in elderly patients with knee 
      osteoarthritis (OA). We hypothesized that MFAT knee infiltration for the 
      treatment of knee OA would yield good clinical results out to two years 
      follow-up. METHODS: Multi-centric, international, open-label study conducted by 
      orthopedic surgery, and/or regenerative medicine facilities utilizing patient 
      registries. Subjects recruited for eligibility. The primary outcome measure was 
      Knee Injury and Osteoarthritis Outcome Score (KOOS). Outcomes and patient factors 
      were compared to baseline, at six, 12, and 24 months. Statistical models were 
      used to assess KOOS subscores and probability of exceeding the Minimally 
      Clinically Important Difference (MCID) or Patient Acceptable Symptom State 
      (PASS), and to assess the effect of the treatment variables on KOOS - Pain. 
      RESULTS: Seventy-five patients, 120 primary treatments, mean age 69.6 years, 
      (95%CI 68.3-70.9), BMI 28.4 (95%CI 27.3-29.6), with KL grade 2 to 4 knee OA 
      treated with a single MFAT injection. KL grades 2 (15.1%), 3 (56.3%), and 4 
      (28.6%), with 20.8% of knees having previously undergone surgery. Patients with 
      KL grade 2 disease had the best results in KOOS - Pain (P = 0.001), at six, 12, 
      and 24 months. Including advanced KL grade 3 and 4 osteoarthritis patients, 
      significant functional and quality of life success was seen in 106/120 treatments 
      (88.3%, 66 patients) at all follow-up time points. Fourteen treatments (11.7%, 9 
      patients) failed prior to the study endpoint. CONCLUSION: This study shows that a 
      single-dose MFAT injection leads to clinical, functional, and quality of life 
      improvement at two years in elderly patients, in KL grades 2 to 4 of knee 
      osteoarthritis. These findings provide evidence that this treatment modality 
      could be a safe and effective option to other commonly available treatments in 
      carefully selected patients.
FAU - Gobbi, Alberto
AU  - Gobbi A
AUID- ORCID: 0000-0002-4868-0119
AD  - O.A.S.I Bioresearch Foundation Gobbi Onlus, Milan, Italy.
FAU - Dallo, Ignacio
AU  - Dallo I
AUID- ORCID: 0000-0003-2744-8342
AD  - O.A.S.I Bioresearch Foundation Gobbi Onlus, Milan, Italy.
FAU - Rogers, Christopher
AU  - Rogers C
AD  - San Diego Orthobiologics Medical Group, San Diego, CA, USA.
FAU - Striano, Richard D
AU  - Striano RD
AUID- ORCID: 0000-0001-6380-4178
AD  - Optimum Joint, Suffern, NY, USA.
FAU - Mautner, K
AU  - Mautner K
AUID- ORCID: 0000-0001-8458-0126
AD  - Emory Sports Medicine Center, Atlanta, GA, USA.
FAU - Bowers, Robert
AU  - Bowers R
AUID- ORCID: 0000-0001-6549-090X
AD  - Emory Sports Medicine Center, Atlanta, GA, USA.
FAU - Rozak, Michael
AU  - Rozak M
AUID- ORCID: 0000-0003-0728-7393
AD  - Emory Sports Medicine Center, Atlanta, GA, USA.
FAU - Bilbool, Norma
AU  - Bilbool N
AD  - Optimum Joint, Suffern, NY, USA.
FAU - Murrell, William D
AU  - Murrell WD
AUID- ORCID: 0000-0001-8835-1806
AD  - Abu Dhabi Knee and Sports Medicine, Healthpoint Hospital, Zayed Sports City, Abu 
      Dhabi, United Arab Emirates. doctormurrell@gmail.com.
AD  - Department of Orthopaedic Surgery, Division of Surgery, Ft. Bliss, William 
      Beaumont Army Medical Center, El Paso, TX, USA. doctormurrell@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210302
PL  - Germany
TA  - Int Orthop
JT  - International orthopaedics
JID - 7705431
SB  - IM
CIN - Int Orthop. 2021 May;45(5):1189-1190. PMID: 33822274
CIN - Int Orthop. 2021 Aug;45(8):2165-2166. PMID: 34255099
MH  - Adipose Tissue
MH  - Aged
MH  - Humans
MH  - Knee Joint/surgery
MH  - *Osteoarthritis, Knee/surgery
MH  - Quality of Life
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Adipose-derived cell therapy
OT  - Autologous microfragmented adipose tissue
OT  - Bio-orthopaedics
OT  - Knee osteoarthritis
OT  - MFAT
OT  - OA
OT  - Orthobiologics
EDAT- 2021/03/03 06:00
MHDA- 2021/06/03 06:00
CRDT- 2021/03/02 06:21
PHST- 2020/09/11 00:00 [received]
PHST- 2021/01/12 00:00 [accepted]
PHST- 2021/03/03 06:00 [pubmed]
PHST- 2021/06/03 06:00 [medline]
PHST- 2021/03/02 06:21 [entrez]
AID - 10.1007/s00264-021-04947-0 [pii]
AID - 10.1007/s00264-021-04947-0 [doi]
PST - ppublish
SO  - Int Orthop. 2021 May;45(5):1179-1188. doi: 10.1007/s00264-021-04947-0. Epub 2021 
      Mar 2.