PMID- 33651486
OWN - NLM
STAT- MEDLINE
DCOM- 20211206
LR  - 20211214
IS  - 1613-4133 (Electronic)
IS  - 1613-4125 (Linking)
VI  - 65
IP  - 9
DP  - 2021 May
TI  - Fish Oil Diet during Pre-mating, Gestation, and Lactation in Adult Offspring Rats 
      on Cancer Cachexia Prevention.
PG  - e2000863
LID - 10.1002/mnfr.202000863 [doi]
AB  - SCOPE: Nutritional supplementation of the maternal diet can modify the cancer 
      susceptibility in adult offspring. Therefore, the authors evaluate the effects of 
      a fish-oil diet administered to a long-term, during pre-mating, gestation, and 
      lactation, in reducing cancer-cachexia damages in adult Walker-256 tumor-bearing 
      offspring. METHODS AND RESULTS: Female rats receive control or fish oil diet 
      during pre-mating, gestation, and lactation. After weaning, male offspring are 
      fed the control diet until adulthood and distributed in (C) control 
      adult-offspring; (W) adult tumor-bearing offspring; (OC) adult-offspring of 
      maternal fish oil diet; (WOC) adult tumor-bearing offspring of maternal fish oil 
      diet groups. Fat body mass is preserved, muscle expression of mechanistic target 
      of rapamicin (mTOR) and eukariotic binding protein of eukariotic factor 4E 
      (4E-BP1) is modified, being associated with lower 20S proteasome protein 
      expression, and the liver alanine aminotransferase (ALT) enzyme content 
      maintained in the WOC group. Also, the OC group shows reduced triglyceridemia. 
      CONCLUSION: In this experimental model of cachexia, the long-term maternal 
      supplementation is a positive strategy to improve liver function and lipid 
      metabolism, as well as to modify muscle proteins expression in the mTOR pathway 
      and also reduce the 20S muscle proteasome protein, without altering the tumor 
      development and muscle wasting in adult tumor-bearing offspring.
CI  - (c) 2021 Wiley-VCH GmbH.
FAU - Oliveira, Sarah Christine Pereira de
AU  - Oliveira SCP
AUID- ORCID: 0000-0002-5635-7741
AD  - Laboratory of Nutrition and Cancer, Department of Structural and Functional 
      Biology, Biology Institute, University of Campinas, Campinas, Brazil.
FAU - Miyaguti, Natalia Angelo da Silva
AU  - Miyaguti NADS
AD  - Laboratory of Nutrition and Cancer, Department of Structural and Functional 
      Biology, Biology Institute, University of Campinas, Campinas, Brazil.
FAU - Russell, Steven Thomas
AU  - Russell ST
AD  - School of Bioscience, College of Health and Life Sciences, Aston University, 
      Birmingham, UK.
FAU - Tobar, Natalia
AU  - Tobar N
AD  - Division of Nuclear Medicine, Department of Radiology, School of Medical 
      Sciences, University of Campinas, Campinas, Brazil.
FAU - Geraldo, Murilo Vieira
AU  - Geraldo MV
AD  - Laboratory of Cancer Cell Biology, Department of Structural and Functional 
      Biology, Biology Institute, University of Campinas, Campinas, Brazil.
FAU - Gomes-Marcondes, Maria Cristina Cintra
AU  - Gomes-Marcondes MCC
AUID- ORCID: 0000-0002-1713-756X
AD  - Laboratory of Nutrition and Cancer, Department of Structural and Functional 
      Biology, Biology Institute, University of Campinas, Campinas, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210410
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - 0 (Fish Oils)
RN  - 0 (Muscle Proteins)
RN  - 0 (Triglycerides)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - EC 2.7.1.1 (mTOR protein, rat)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Alanine Transaminase/metabolism
MH  - Animals
MH  - Body Composition
MH  - Cachexia/*prevention & control
MH  - Carcinoma 256, Walker/*complications/metabolism
MH  - Dietary Supplements
MH  - Female
MH  - Fish Oils/*administration & dosage
MH  - Lactation
MH  - Male
MH  - Muscle Proteins/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - TOR Serine-Threonine Kinases/physiology
MH  - Triglycerides/blood
OTO - NOTNLM
OT  - cachexia
OT  - fish oil
OT  - maternal influence
OT  - nutritional supplementation
OT  - omega-3
EDAT- 2021/03/03 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/03/02 12:17
PHST- 2021/02/18 00:00 [revised]
PHST- 2020/09/03 00:00 [received]
PHST- 2021/03/03 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/03/02 12:17 [entrez]
AID - 10.1002/mnfr.202000863 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2021 May;65(9):e2000863. doi: 10.1002/mnfr.202000863. Epub 
      2021 Apr 10.