PMID- 3365280
OWN - NLM
STAT- MEDLINE
DCOM- 19880602
LR  - 20151119
IS  - 0004-4172 (Print)
IS  - 0004-4172 (Linking)
VI  - 38
IP  - 1
DP  - 1988 Jan
TI  - Immunopharmacological actions of the new antiallergic drug butyl 
      3'-(1H-tetrazol-5-yl)oxanilate. 5th communication: effects on immunological 
      reactions in mice and humans.
PG  - 88-92
AB  - The effects of butyl 3'-(1H-tetrazol-5-yl)oxanilate (WP-833), a new antiallergic 
      drug, on immunological reactions in mice and humans were studied in view of 
      possible side effects. Hemagglutinin formation in mice immunized with sheep red 
      blood cells was not suppressed by WP-833 administered i.p. or p.o. for 3 days 
      either before or after immunization. In addition, the same treatments with WP-833 
      showed no suppression of hapten-specific immunoglobulin E (IgE) or immunoglobulin 
      G (IgG) antibody formation in mice immunized with dinitrophenyl-conjugated 
      ovalbumin mixed with alum. The proliferation of human peripheral blood 
      lymphocytes induced by concanavalin A, phytohemagglutinin-P, pokeweed mitogen, 
      protein A or Cowan I was not suppressed by WP-833. Nitroblue tetrazolium 
      reduction test, phagocytosis and chemotaxis in human neutrophils were not 
      inhibited by WP-833.
FAU - Yanagihara, Y
AU  - Yanagihara Y
AD  - Clinical Research Center for Allergy, National Sagamihara Hospital, Kanagawa, 
      Japan.
FAU - Abe, T
AU  - Abe T
FAU - Kuroda, T
AU  - Kuroda T
FAU - Shida, T
AU  - Shida T
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Arzneimittelforschung
JT  - Arzneimittel-Forschung
JID - 0372660
RN  - 0 (Azoles)
RN  - 0 (Dinitrophenols)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Mitogens)
RN  - 0 (Tetrazoles)
RN  - 0 (butyl 3-(1H-tetrazol-5-yl)oxanilate)
RN  - 298-83-9 (Nitroblue Tetrazolium)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Azoles/*pharmacology
MH  - Dinitrophenols/immunology
MH  - Humans
MH  - Immunity/*drug effects
MH  - Immunoglobulin E/biosynthesis
MH  - Immunoglobulin G/biosynthesis
MH  - Lymphocytes/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mitogens
MH  - Neutrophils/drug effects
MH  - Nitroblue Tetrazolium
MH  - Phagocytosis/drug effects
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Tetrazoles/*pharmacology
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
PST - ppublish
SO  - Arzneimittelforschung. 1988 Jan;38(1):88-92.