PMID- 33653455
OWN - NLM
STAT- MEDLINE
DCOM- 20210611
LR  - 20210611
IS  - 1533-4899 (Electronic)
IS  - 1533-4880 (Linking)
VI  - 21
IP  - 5
DP  - 2021 May 1
TI  - TiO(2)-Chitosan Hybrid Materials for Drug Delivery Applications: Conjugation 
      Reaction with a Model Drug and Evaluation of the Functional Properties.
PG  - 2892-2900
LID - 10.1166/jnn.2021.19050 [doi]
AB  - The combination of TiO(2) and chitosan is known to allow the achievement of 
      implantable devices which combines the mechanical properties of TiO(2), with the 
      presence of chitosan, which ensures antibacterial properties combined with an 
      in-situ drug-delivery of biomolecules physisorbed and/or covalently linked to 
      chitosan. In this study, 5-aminofluorescein (5-AF), a derivative of fluorescein 
      containing a primary amino group, has been used as model molecule to simulate a 
      drug. This dye is characterized by low cost and low toxicity, and due to its high 
      molar absorptivity it can easily be detected by means of absorption and emission 
      spectroscopies. The combination of 5-AF and maleic anhydride (MA) with 
      TiO(2)-chitosan materials has generated a range of novel hybrid materials tailored 
      to applications in localized stimuli-responsive drug delivery systems. Maleic 
      anhydride has been used as pH sensitive spacer for the covalent functionalization 
      of the TiO(2)-chitosan hybrid with MA as linker molecule. This functionalization 
      allowed to obtain a pH-sensitive hybrid material. The efficiency of the 
      functionalization has been verified by means of different physico-chemical 
      characterization techniques. The behaviour of the functionalized materials is 
      related to different parameters, among which the ratio between 
      physisorbed/coordinated and chemisorbed 5-AF and the matrix degradation. 
      Moreover, delivery tests in simulated body solutions at different pH have been 
      performed showing a pH-sensitive drug delivery behaviour and indicating that the 
      release of 5-AF is favoured at basic pH.
FAU - Cerrato, Giuseppina
AU  - Cerrato G
AD  - Dipartimento di Chimica & Centro Interdipartimentale NIS (Nanostructured 
      Interfaces and Surfaces) Universita di Torino & Consorzio Interuniversitario 
      Nazionale per la Scienza a la Tecnologia dei Materiali-Unita di Ricerca di 
      Torino, via P. Giuria 7, 10125 Torino, Italy.
FAU - Martra, Gianmario
AU  - Martra G
AD  - Dipartimento di Chimica & Centro Interdipartimentale NIS (Nanostructured 
      Interfaces and Surfaces) Universita di Torino & Consorzio Interuniversitario 
      Nazionale per la Scienza a la Tecnologia dei Materiali-Unita di Ricerca di 
      Torino, via P. Giuria 7, 10125 Torino, Italy.
FAU - Viscardi, Guido
AU  - Viscardi G
AD  - Dipartimento di Chimica & Centro Interdipartimentale NIS (Nanostructured 
      Interfaces and Surfaces) Universita di Torino & Consorzio Interuniversitario 
      Nazionale per la Scienza a la Tecnologia dei Materiali-Unita di Ricerca di 
      Torino, via P. Giuria 7, 10125 Torino, Italy.
FAU - Signoretto, Michela
AU  - Signoretto M
AD  - Dipartimento di Scienze Molecolari e Nanosistemi, Universita Ca' Foscari Venezia 
      & Consorzio Interuniversitario Nazionale per la Scienza a la Tecnologia dei 
      Materiali-Unita di Ricerca di Venezia, via Torino 155, 30172 Mestre Venezi, 
      Italy.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Nanosci Nanotechnol
JT  - Journal of nanoscience and nanotechnology
JID - 101088195
RN  - 0 (Pharmaceutical Preparations)
RN  - 15FIX9V2JP (titanium dioxide)
RN  - 9012-76-4 (Chitosan)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - *Chitosan
MH  - Drug Delivery Systems
MH  - Hydrogen-Ion Concentration
MH  - *Pharmaceutical Preparations
MH  - Titanium
EDAT- 2021/03/04 06:00
MHDA- 2021/06/12 06:00
CRDT- 2021/03/03 05:35
PHST- 2021/03/03 05:35 [entrez]
PHST- 2021/03/04 06:00 [pubmed]
PHST- 2021/06/12 06:00 [medline]
AID - 10.1166/jnn.2021.19050 [doi]
PST - ppublish
SO  - J Nanosci Nanotechnol. 2021 May 1;21(5):2892-2900. doi: 10.1166/jnn.2021.19050.