PMID- 33653904
OWN - NLM
STAT- MEDLINE
DCOM- 20210521
LR  - 20220421
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 96
IP  - 16
DP  - 2021 Apr 20
TI  - Association of Spectral-Domain OCT With Long-term Disability Worsening in 
      Multiple Sclerosis.
PG  - e2058-e2069
LID - 10.1212/WNL.0000000000011788 [doi]
AB  - OBJECTIVE: To evaluate whether a retinal spectral-domain optical coherence 
      tomography (SD-OCT) assessment at baseline is associated with long-term 
      disability worsening in people with multiple sclerosis (PwMS), we performed 
      SD-OCT and Expanded Disability Status Scale (EDSS) assessments among 132 PwMS at 
      baseline and at a median of 10 years later. METHODS: In this prospective, 
      longitudinal study, participants underwent SD-OCT, EDSS, and visual acuity (VA) 
      assessments at baseline and at follow-up. Statistical analyses were performed 
      using generalized linear regression models, adjusted for age, sex, race, multiple 
      sclerosis (MS) subtype, and baseline disability. We defined clinically meaningful 
      EDSS worsening as an increase of >/=2.0 if baseline EDSS score was <6.0 or an 
      increase of >/=1.0 if baseline EDSS score was >/=6.0. RESULTS: A total of 132 PwMS 
      (mean age 43 years; 106 patients with relapsing-remitting MS) were included in 
      analyses. Median duration of follow-up was 10.4 years. In multivariable models 
      excluding eyes with prior optic neuritis, relative to patients with an average 
      baseline ganglion cell + inner plexiform layer (GCIPL) thickness >/=70 microm (the mean 
      GCIPL thickness of all eyes at baseline), an average baseline GCIPL thickness <70 
      microm was associated with a 4-fold increased odds of meaningful EDSS worsening 
      (adjusted odds ratio [OR] 3.97, 95% confidence interval [CI] 1.24-12.70; p = 
      0.02) and an almost 3-fold increased odds of low-contrast VA worsening (adjusted 
      OR 2.93, 95% CI 1.40-6.13; p = 0.04). CONCLUSIONS: Lower baseline GCIPL thickness 
      on SD-OCT is independently associated with long-term disability worsening in MS. 
      Accordingly, SD-OCT at a single time point may help guide therapeutic 
      decision-making among individual PwMS. CLASSIFICATION OF EVIDENCE: This study 
      provides Class I evidence that lower baseline GCIPL thickness on SD-OCT is 
      independently associated with long-term disability worsening in MS.
CI  - (c) 2021 American Academy of Neurology.
FAU - Lambe, Jeffrey
AU  - Lambe J
AUID- ORCID: 0000-0002-3306-0988
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Fitzgerald, Kathryn C
AU  - Fitzgerald KC
AUID- ORCID: 0000-0003-3137-0322
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Murphy, Olwen C
AU  - Murphy OC
AUID- ORCID: 0000-0001-7880-8948
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Filippatou, Angeliki G
AU  - Filippatou AG
AUID- ORCID: 0000-0003-0419-233X
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Sotirchos, Elias S
AU  - Sotirchos ES
AUID- ORCID: 0000-0002-8812-1637
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Kalaitzidis, Grigorios
AU  - Kalaitzidis G
AUID- ORCID: 0000-0001-7680-3609
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Vasileiou, Elena
AU  - Vasileiou E
AUID- ORCID: 0000-0002-8639-8405
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Pellegrini, Nicole
AU  - Pellegrini N
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Ogbuokiri, Esther
AU  - Ogbuokiri E
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Toliver, Brandon
AU  - Toliver B
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Luciano, Nicholas J
AU  - Luciano NJ
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Davis, Simidele
AU  - Davis S
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Fioravante, Nicholas
AU  - Fioravante N
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Kwakyi, Ohemaa
AU  - Kwakyi O
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Risher, Hunter
AU  - Risher H
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Crainiceanu, Ciprian M
AU  - Crainiceanu CM
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Prince, Jerry L
AU  - Prince JL
AUID- ORCID: 0000-0002-6553-0876
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Newsome, Scott D
AU  - Newsome SD
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Mowry, Ellen M
AU  - Mowry EM
AUID- ORCID: 0000-0003-0623-5188
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Saidha, Shiv
AU  - Saidha S
AUID- ORCID: 0000-0001-6387-0714
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD.
FAU - Calabresi, Peter A
AU  - Calabresi PA
AUID- ORCID: 0000-0002-7776-6472
AD  - From the Department of Neurology (J.L., K.C.F., O.C.M., A.G.F., E.S.S., G.K., 
      E.V., N.P., E.O., B.T., N.J.L., S.D., N.F., O.K., H.R., S.D.N., E.M.M., S.S., 
      P.A.C.), Johns Hopkins University School of Medicine; and Departments of 
      Biostatistics (C.M.C.) and Electrical and Computer Engineering (J.L.P.), Johns 
      Hopkins University, Baltimore, MD. calabresi@jhmi.edu.
LA  - eng
GR  - K01 MH121582/MH/NIMH NIH HHS/United States
GR  - R01 NS082347/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210302
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
CIN - Neurology. 2021 Apr 20;96(16):731-732. PMID: 33653903
MH  - Adult
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*diagnostic imaging/*pathology
MH  - Prospective Studies
MH  - Tomography, Optical Coherence
PMC - PMC8166450
EDAT- 2021/03/04 06:00
MHDA- 2021/05/22 06:00
PMCR- 2022/04/20
CRDT- 2021/03/03 05:39
PHST- 2020/06/27 00:00 [received]
PHST- 2021/01/19 00:00 [accepted]
PHST- 2021/03/04 06:00 [pubmed]
PHST- 2021/05/22 06:00 [medline]
PHST- 2021/03/03 05:39 [entrez]
PHST- 2022/04/20 00:00 [pmc-release]
AID - WNL.0000000000011788 [pii]
AID - NEUROLOGY2020116798 [pii]
AID - 10.1212/WNL.0000000000011788 [doi]
PST - ppublish
SO  - Neurology. 2021 Apr 20;96(16):e2058-e2069. doi: 10.1212/WNL.0000000000011788. 
      Epub 2021 Mar 2.