PMID- 33653978
OWN - NLM
STAT- MEDLINE
DCOM- 20210510
LR  - 20210510
IS  - 1532-0979 (Electronic)
IS  - 0147-5185 (Linking)
VI  - 45
IP  - 5
DP  - 2021 May 1
TI  - FOS Rearrangement and Expression in Cementoblastoma.
PG  - 690-693
LID - 10.1097/PAS.0000000000001695 [doi]
AB  - Cementoblastomas are rare odontogenic tumors developing in close proximity to the 
      roots of teeth. Due to their striking morphologic resemblance to osteoblastomas 
      of the peripheral skeleton, we set out to determine whether cementoblastomas 
      harbor the same FOS rearrangements with overexpression of c-FOS as has recently 
      been described for osteoblastomas. In total, 16 cementoblastomas were analyzed 
      for FOS expression by immunohistochemistry and for FOS rearrangements by 
      fluorescence in situ hybridization (FISH). We observed strong and diffuse 
      staining of c-FOS in 71% of cementoblastomas and identified a FOS rearrangement 
      in all cases (n=3) applicable for FISH. In the remaining cases, FISH failed due 
      to decalcification. Cementoblastomas harbor similar FOS rearrangements and show 
      overexpression of c-FOS like osteoblastomas, suggesting that both entities might 
      represent parts of the spectrum of the same disease.
CI  - Copyright (c) 2021 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Lam, Suk Wai
AU  - Lam SW
AD  - Departments of Pathology.
FAU - Cleven, Arjen H G
AU  - Cleven AHG
AD  - Departments of Pathology.
FAU - Briaire-de Bruijn, Inge H
AU  - Briaire-de Bruijn IH
AD  - Departments of Pathology.
FAU - Schreuder, Willem H
AU  - Schreuder WH
AD  - Department of Oral and Maxillofacial Surgery/Head and Neck Surgery, Amsterdam 
      University Medical Center/Antoni van Leeuwenhoek Hospital.
FAU - Kroon, Herman M
AU  - Kroon HM
AD  - Radiology.
FAU - Savci-Heijink, Dilara C
AU  - Savci-Heijink DC
AD  - Department of Pathology, Academic Medical Center, Amsterdam.
FAU - Suurmeijer, Albert J H
AU  - Suurmeijer AJH
AD  - Department of Pathology and Medical Biology, University Medical Center Groningen, 
      University of Groningen, Groningen, The Netherlands.
FAU - Szuhai, Karoly
AU  - Szuhai K
AD  - Cell and Chemical Biology, Leiden University Medical Center, Leiden.
FAU - Bovee, Judith V M G
AU  - Bovee JVMG
AD  - Departments of Pathology.
FAU - Baumhoer, Daniel
AU  - Baumhoer D
AD  - Bone Tumour Reference Centre, Institute of Pathology, University Hospital Basel, 
      University of Basel, Basel, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (FOS protein, human)
RN  - 0 (Proto-Oncogene Proteins c-fos)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Biomarkers, Tumor/analysis/genetics
MH  - *Bone Neoplasms/chemistry/genetics/pathology
MH  - Child
MH  - *Dental Cementum/chemistry/pathology
MH  - Female
MH  - *Gene Rearrangement
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - *Odontogenic Tumors/chemistry/genetics/pathology
MH  - *Osteoblastoma/chemistry/genetics/pathology
MH  - *Proto-Oncogene Proteins c-fos/analysis/genetics
MH  - Switzerland
MH  - *Tooth Root/chemistry/pathology
MH  - Young Adult
COIS- Conflicts of Interest and Source of Funding: The authors have disclosed that they 
      have no significant relationships with, or financial interest in, any commercial 
      companies pertaining to this article.
EDAT- 2021/03/04 06:00
MHDA- 2021/05/11 06:00
CRDT- 2021/03/03 05:39
PHST- 2021/03/04 06:00 [pubmed]
PHST- 2021/05/11 06:00 [medline]
PHST- 2021/03/03 05:39 [entrez]
AID - 00000478-202105000-00010 [pii]
AID - 10.1097/PAS.0000000000001695 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2021 May 1;45(5):690-693. doi: 10.1097/PAS.0000000000001695.