PMID- 33654370
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220421
IS  - 1108-7471 (Print)
IS  - 1792-7463 (Electronic)
IS  - 1108-7471 (Linking)
VI  - 34
IP  - 2
DP  - 2021
TI  - International, multicenter retrospective trial comparing the efficacy and safety 
      of bi-flanged versus lumen-apposing metal stents for endoscopic drainage of 
      walled-off pancreatic necrosis.
PG  - 273-281
LID - 10.20524/aog.2021.0570 [doi]
AB  - BACKGROUND: To compare fully covered bi-flanged metal stents (BFMS) and 
      lumen-apposing metal stents (LAMS) for endoscopic ultrasound (EUS)-guided 
      drainage/debridement of pancreatic walled-off necrosis (WON). METHODS: Patients 
      with WON managed by EUS-guided therapy were divided into those who underwent: 1) 
      drainage using BFMS; and 2) drainage using LAMS and scheduled direct endoscopic 
      necrosectomy (DEN). Clinical success (resolution of the WON), technical success 
      (successful stent placement), and adverse events (AEs) were evaluated. RESULTS: 
      387 patients underwent WON endoscopic drainage, 205 using BFMS and 182 using 
      LAMS. The clinical success in the BFMS or LAMS groups were similar (197 [96.1%] 
      vs. 174 [95.6%]; P=0.81). Median number of procedures required for WON resolution 
      was significantly lower in BFMS compared to LAMS (2 vs. 3, P<0.001). Technical 
      success for stent placement was similar in BFMS and LAMS groups (203 [99%] vs. 
      180 [99%], P=0.90). Procedure-related AEs were similar in the BFMS and LAMS 
      groups (19 [9.3%] vs. 20 [10.9%], P=0.61). Stent dysfunction with occluding 
      debris was higher in the BFMS group compared to LAMS group (21 [10.2 %] vs. 11 
      [5.9%], P=0.04). The migration rate was higher in the BFMS group than in the LAMS 
      group (15 [7.3%] vs. 3 [1.6%]; P<0.001). DEN was required in 23 [11.2%] patients 
      in the BFMS group after lack of WON resolution by conservative means. CONCLUSION: 
      BFMS with a "step-up approach" and LAMS with scheduled DEN are both safe and 
      effective for EUS-guided drainage/debridement of WON.
CI  - Copyright: (c) 2021 Hellenic Society of Gastroenterology.
FAU - Siddiqui, Ali
AU  - Siddiqui A
AD  - Thomas Jefferson University, Philadelphia, PA, USA (Ali Siddiqui, Megan Murphy, 
      David E. Loren, Arish Noor, Tayeban Mumtaz).
FAU - Naveed, Mariam
AU  - Naveed M
AD  - University of Iowa, Iowa City, IA, USA (Mariam Naveed, Patrick Ten Eyck).
FAU - Basha, Jahangeer
AU  - Basha J
AD  - Asian Institute of Gastroenterology, Hyderabad, India (Jahangeer Basha, Sundeep 
      Lakhtakia, Rupjyoti Talukdar, Mohan K. Ramchandani, Zaheer Nabi, Rajesh Gupta, 
      Rakesh Kalalala, Nageshwar D. Reddy).
FAU - Lakhtakia, Sundeep
AU  - Lakhtakia S
AD  - Asian Institute of Gastroenterology, Hyderabad, India (Jahangeer Basha, Sundeep 
      Lakhtakia, Rupjyoti Talukdar, Mohan K. Ramchandani, Zaheer Nabi, Rajesh Gupta, 
      Rakesh Kalalala, Nageshwar D. Reddy).
FAU - Nieto, Jose
AU  - Nieto J
AD  - Borland-Groover Clinic, Jacksonville, FL, USA (Jose Nieto).
FAU - Shah, Janak
AU  - Shah J
AD  - Division of Gastroenterology, California Pacific Medical Center, San Francisco, 
      CA, USA (Janak Shah, Kenneth Binmoeller).
FAU - Binmoeller, Kenneth
AU  - Binmoeller K
AD  - Division of Gastroenterology, California Pacific Medical Center, San Francisco, 
      CA, USA (Janak Shah, Kenneth Binmoeller).
FAU - Murphy, Megan
AU  - Murphy M
AD  - Thomas Jefferson University, Philadelphia, PA, USA (Ali Siddiqui, Megan Murphy, 
      David E. Loren, Arish Noor, Tayeban Mumtaz).
FAU - Talukdar, Rupjyoti
AU  - Talukdar R
AD  - Asian Institute of Gastroenterology, Hyderabad, India (Jahangeer Basha, Sundeep 
      Lakhtakia, Rupjyoti Talukdar, Mohan K. Ramchandani, Zaheer Nabi, Rajesh Gupta, 
      Rakesh Kalalala, Nageshwar D. Reddy).
FAU - Ramchandani, Mohan K
AU  - Ramchandani MK
AD  - Asian Institute of Gastroenterology, Hyderabad, India (Jahangeer Basha, Sundeep 
      Lakhtakia, Rupjyoti Talukdar, Mohan K. Ramchandani, Zaheer Nabi, Rajesh Gupta, 
      Rakesh Kalalala, Nageshwar D. Reddy).
FAU - Nabi, Zaheer
AU  - Nabi Z
AD  - Asian Institute of Gastroenterology, Hyderabad, India (Jahangeer Basha, Sundeep 
      Lakhtakia, Rupjyoti Talukdar, Mohan K. Ramchandani, Zaheer Nabi, Rajesh Gupta, 
      Rakesh Kalalala, Nageshwar D. Reddy).
FAU - Gupta, Rajesh
AU  - Gupta R
AD  - Asian Institute of Gastroenterology, Hyderabad, India (Jahangeer Basha, Sundeep 
      Lakhtakia, Rupjyoti Talukdar, Mohan K. Ramchandani, Zaheer Nabi, Rajesh Gupta, 
      Rakesh Kalalala, Nageshwar D. Reddy).
FAU - Kowalski, Thomas E
AU  - Kowalski TE
AD  - New York Presbyterian Hospital/Weill Cornell Medical Center, New York, NY, USA 
      (Thomas E. Kowalski, Reem Z. Sharaiha, Michel Kahaleh).
FAU - Loren, David E
AU  - Loren DE
AD  - Thomas Jefferson University, Philadelphia, PA, USA (Ali Siddiqui, Megan Murphy, 
      David E. Loren, Arish Noor, Tayeban Mumtaz).
FAU - Sharaiha, Reem Z
AU  - Sharaiha RZ
AD  - New York Presbyterian Hospital/Weill Cornell Medical Center, New York, NY, USA 
      (Thomas E. Kowalski, Reem Z. Sharaiha, Michel Kahaleh).
FAU - Kahaleh, Michel
AU  - Kahaleh M
AD  - New York Presbyterian Hospital/Weill Cornell Medical Center, New York, NY, USA 
      (Thomas E. Kowalski, Reem Z. Sharaiha, Michel Kahaleh).
FAU - Eyck, Patrick Ten
AU  - Eyck PT
AD  - University of Iowa, Iowa City, IA, USA (Mariam Naveed, Patrick Ten Eyck).
FAU - Noor, Arish
AU  - Noor A
AD  - Thomas Jefferson University, Philadelphia, PA, USA (Ali Siddiqui, Megan Murphy, 
      David E. Loren, Arish Noor, Tayeban Mumtaz).
FAU - Mumtaz, Tayebah
AU  - Mumtaz T
AD  - Thomas Jefferson University, Philadelphia, PA, USA (Ali Siddiqui, Megan Murphy, 
      David E. Loren, Arish Noor, Tayeban Mumtaz).
FAU - Kalalala, Rakesh
AU  - Kalalala R
AD  - Asian Institute of Gastroenterology, Hyderabad, India (Jahangeer Basha, Sundeep 
      Lakhtakia, Rupjyoti Talukdar, Mohan K. Ramchandani, Zaheer Nabi, Rajesh Gupta, 
      Rakesh Kalalala, Nageshwar D. Reddy).
FAU - Reddy, Nageshwar D
AU  - Reddy ND
AD  - Asian Institute of Gastroenterology, Hyderabad, India (Jahangeer Basha, Sundeep 
      Lakhtakia, Rupjyoti Talukdar, Mohan K. Ramchandani, Zaheer Nabi, Rajesh Gupta, 
      Rakesh Kalalala, Nageshwar D. Reddy).
FAU - Adler, Douglas G
AU  - Adler DG
AD  - University of Utah, Salt Lake City, UT, USA (Douglas G. Adler).
LA  - eng
PT  - Journal Article
DEP - 20210104
PL  - Greece
TA  - Ann Gastroenterol
JT  - Annals of gastroenterology
JID - 101121847
PMC - PMC7903561
OTO - NOTNLM
OT  - Pancreatic walled off necrosis
OT  - acute pancreatitis
OT  - bi-flanged metal stents
OT  - endosonography
OT  - lumen-apposing metal stents
COIS- Conflict of Interest: None
EDAT- 2021/03/04 06:00
MHDA- 2021/03/04 06:01
PMCR- 2021/01/01
CRDT- 2021/03/03 05:46
PHST- 2019/12/15 00:00 [received]
PHST- 2020/09/10 00:00 [accepted]
PHST- 2021/03/03 05:46 [entrez]
PHST- 2021/03/04 06:00 [pubmed]
PHST- 2021/03/04 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - AnnGastroenterol-34-273 [pii]
AID - 10.20524/aog.2021.0570 [doi]
PST - ppublish
SO  - Ann Gastroenterol. 2021;34(2):273-281. doi: 10.20524/aog.2021.0570. Epub 2021 Jan 
      4.