PMID- 33654596
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231110
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 13
IP  - 1
DP  - 2021 Jan 25
TI  - Association of Serum Vitamin D and Immunoglobulin E Levels With Severity of 
      Allergic Rhinitis.
PG  - e12911
LID - 10.7759/cureus.12911 [doi]
LID - e12911
AB  - Objective The aim of this study was to determine the association of serum vitamin 
      D and immunoglobulin E (IgE) levels with the severity of allergic rhinitis (AR). 
      Methods This case-control study was conducted at Mayo Hospital, Lahore, from June 
      to September 2020 after obtaining ethical approval. Patients of AR were included 
      and divided with the help of allergic rhinitis and its impact on asthma (ARIA) 
      classification, into group A (cases), patients presenting with moderate to severe 
      symptoms, and into group B (control), patients with mild symptoms, after 
      treatment of AR. The mean difference between serum IgE and serum Vitamin D levels 
      of both groups were compared by t-test. Association was determined by logistic 
      regression and odds ratio. Results A total of 224 patients were included in the 
      study, 112 patients in group A and 112 patients in group B. There were 106 
      (47.3%) female and 118 (52.7%) male. The mean age of patients in group A was 
      26.78+/- 8.92 years and in group B, it was 25.72+/-8.12 years. Mean serum vitamin D 
      levels in group A were 16.24+/-6.7 ng/ml and in group B 26.92+/-35 ng/ml (p=0.0001). 
      Mean serum IgE levels in group A were 383.69+/-154.86 IU/ml and in group B, they 
      were 373.03+/-106.83 IU/ml (p=0.0001). Vitamin D deficient patients were 24 times 
      more likely to develop moderate to severe AR disease. Conclusion This study 
      showed that in moderate-severe AR, IgE levels are raised statistically as 
      compared to mild AR and the deficiency of Vitamin D is associated with increasing 
      severity of allergic rhinitis symptoms.
CI  - Copyright (c) 2021, Awan et al.
FAU - Awan, Nukhbat U
AU  - Awan NU
AD  - Ear, Nose, Throat (ENT), King Edward Medical University, Mayo Hospital, Lahore, 
      PAK.
FAU - Sohail, Shahzada K
AU  - Sohail SK
AD  - Basic Medical Sciences, College of Medicine, University of Bisha, Bisha, SAU.
FAU - Naumeri, Fatima
AU  - Naumeri F
AD  - Pediatric Surgery, King Edward Medical University, Mayo Hospital, Lahore, PAK.
FAU - Niazi, Shahida
AU  - Niazi S
AD  - Department of Pathology, Sharif Medical & Dental College/Sharif Medical City 
      Hospital, Lahore, PAK.
FAU - Cheema, Khalid
AU  - Cheema K
AD  - Ear, Nose, Throat (ENT), King Edward Medical University, Mayo Hospital, Lahore, 
      PAK.
FAU - Qamar, Samina
AU  - Qamar S
AD  - Pathology, King Edward Medical University, Lahore, PAK.
FAU - Rizvi, Syeda Fatima
AU  - Rizvi SF
AD  - Basic Medical Sciences, College of Medicine, University of Bisha, Bisha, SAU.
LA  - eng
PT  - Journal Article
DEP - 20210125
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC7905192
OTO - NOTNLM
OT  - allergic rhinitis
OT  - aria classification
OT  - serum immunoglobulin e levels
OT  - serum vitamin d levels
OT  - severity
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/03/04 06:00
MHDA- 2021/03/04 06:01
PMCR- 2021/01/25
CRDT- 2021/03/03 05:47
PHST- 2021/03/03 05:47 [entrez]
PHST- 2021/03/04 06:00 [pubmed]
PHST- 2021/03/04 06:01 [medline]
PHST- 2021/01/25 00:00 [pmc-release]
AID - 10.7759/cureus.12911 [doi]
PST - epublish
SO  - Cureus. 2021 Jan 25;13(1):e12911. doi: 10.7759/cureus.12911.