PMID- 33655582
OWN - NLM
STAT- MEDLINE
DCOM- 20210917
LR  - 20210917
IS  - 1939-165X (Electronic)
IS  - 0275-6382 (Linking)
VI  - 50
IP  - 1
DP  - 2021 Mar
TI  - Precursor-targeted immune-mediated anemia in a dog with a stage IV mast cell 
      tumor and bone marrow infiltration.
PG  - 151-157
LID - 10.1111/vcp.12982 [doi]
AB  - A 12-year-old spayed female Shiba Inu dog was referred to our hospital for a 
      suspected mast cell tumor (MCT) of the bone marrow (BM). Laboratory abnormalities 
      included severe nonregenerative anemia (packed cell volume or PCV: 12.5%; 
      reference interval (RI): 37.3-61.7%; reticulocytes: 35.1 x 10(3) /microL; RI: 
      10-110 x 10(3) /microL), and a few mast cells were visualized in the blood smear 
      examination. The BM was hypercellular with hematopoietic cells, a decreased 
      myeloid:erythroid (M:E) ratio (0.77; RI, 0.9-1.8), and no dysplastic 
      hematopoietic cells. Mast cells accounted for 11.5% of the total nucleated BM 
      cells. Neoplastic mast cells and histiocytes phagocytizing erythroid progenitor 
      cells were occasionally noted. The dog was diagnosed with precursor-targeted 
      immune-mediated anemia (PIMA) concurrent and a stage IV MCT infiltrating the BM. 
      Multimodal treatment included toceranib, imatinib, vinblastine, lomustine (CCNU), 
      prednisolone, cyclosporine, mycophenolate mofetil, and a blood transfusion. The 
      dog died due to MCT progression lasting 139 days after the initial BM 
      examination. To the best of our knowledge, this is the first report of a dog 
      presenting with PIMA and a stage IV MCT infiltrating the BM.
CI  - (c) 2021 American Society for Veterinary Clinical Pathology.
FAU - Akiyoshi, Makoto
AU  - Akiyoshi M
AUID- ORCID: 0000-0002-2875-2066
AD  - Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, 
      Azabu University, Sagamihara City, Japan.
AD  - Akiyoshi Animal Clinic, Yamato City, Japan.
FAU - Hisasue, Masaharu
AU  - Hisasue M
AUID- ORCID: 0000-0003-3738-6659
AD  - Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, 
      Azabu University, Sagamihara City, Japan.
FAU - Neo, Sakurako
AU  - Neo S
AD  - Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, 
      Azabu University, Sagamihara City, Japan.
FAU - Akiyoshi, Masami
AU  - Akiyoshi M
AD  - Akiyoshi Animal Clinic, Yamato City, Japan.
LA  - eng
PT  - Case Reports
DEP - 20210302
PL  - United States
TA  - Vet Clin Pathol
JT  - Veterinary clinical pathology
JID - 9880575
SB  - IM
MH  - *Anemia/veterinary
MH  - Animals
MH  - Bone Marrow
MH  - *Dog Diseases/diagnosis
MH  - Dogs
MH  - Female
MH  - Mast Cells
MH  - *Neoplasms/veterinary
OTO - NOTNLM
OT  - NRIMA
OT  - c-kit exon 11 mutation
OT  - canine
OT  - immune-mediated hemolytic anemia
OT  - ineffective erythropoiesis
OT  - rubriphagocytosis
EDAT- 2021/03/04 06:00
MHDA- 2021/09/18 06:00
CRDT- 2021/03/03 05:53
PHST- 2020/04/15 00:00 [revised]
PHST- 2019/09/28 00:00 [received]
PHST- 2020/04/15 00:00 [accepted]
PHST- 2021/03/04 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2021/03/03 05:53 [entrez]
AID - 10.1111/vcp.12982 [doi]
PST - ppublish
SO  - Vet Clin Pathol. 2021 Mar;50(1):151-157. doi: 10.1111/vcp.12982. Epub 2021 Mar 2.