PMID- 33656036
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20210419
LR  - 20210419
IS  - 1759-9679 (Electronic)
IS  - 1759-9660 (Linking)
VI  - 13
IP  - 11
DP  - 2021 Mar 21
TI  - A novel all-3D-printed thread-based microfluidic device with an embedded 
      electrochemical detector: first application in environmental analysis of nitrite.
PG  - 1349-1357
LID - 10.1039/d1ay00070e [doi]
AB  - A microfluidic thread electroanalytical device (muTED) containing an embedded 
      electrochemical detector is presented for the first time in this work. This novel 
      device was entirely produced in an automated way using the fused deposition 
      modeling (FDM) 3D printing technique. The main platform was fabricated with 
      acrylonitrile butadiene styrene (ABS) filament, while the integrated 
      electrochemical detector was produced using a commercial conductive filament 
      composed of carbon black and polylactic acid (CB/PLA). The microfluidic channels 
      consisted of cotton threads, which act as passive pumps, and the muTED was used 
      for microflow injection analysis (muFIA). As a proof of concept, this muFIA system 
      was utilized for the amperometric sensing of nitrite in natural waters. This is 
      the first report on the use of both muTEDs and 3D-printed CB/PLA electrodes to 
      determine this species. This fully 3D-printed muTED was characterized and all 
      experimental and instrumental parameters related to the method were studied and 
      optimized. Using the best conditions, the proposed approach showed a linear 
      response in the concentration range from 8 to 200 mumol L(-1) and a limit of 
      detection (LOD) of 2.39 mumol L(-1). The LOD obtained here was ca. ten-fold lower 
      than the maximum contaminant level for nitrite in drinking water established by 
      the Brazilian and US legislation. Moreover, the platform presented good 
      repeatability and reproducibility (relative standard deviations (RSDs) were 2.1% 
      and 2.5%, respectively). Lastly, the 3D-printed muTED was applied for the 
      quantification of nitrite in well water samples and the results obtained showed 
      good precision (RSD < 3%) and excellent concordance (relative error was ca.+/-3%) 
      with those achieved by ion chromatography, used for validation.
FAU - Carvalho, Rayan Marcel
AU  - Carvalho RM
AD  - Chemistry Institute, Federal University of Mato Grosso do Sul, Campo Grande, MS 
      79074-460, Brazil. bruno.lucca@ufms.br.
FAU - Ferreira, Valdir Souza
AU  - Ferreira VS
FAU - Lucca, Bruno Gabriel
AU  - Lucca BG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210303
PL  - England
TA  - Anal Methods
JT  - Analytical methods : advancing methods and applications
JID - 101519733
SB  - IM
EDAT- 2021/03/04 06:00
MHDA- 2021/03/04 06:01
CRDT- 2021/03/03 08:53
PHST- 2021/03/04 06:00 [pubmed]
PHST- 2021/03/04 06:01 [medline]
PHST- 2021/03/03 08:53 [entrez]
AID - 10.1039/d1ay00070e [doi]
PST - ppublish
SO  - Anal Methods. 2021 Mar 21;13(11):1349-1357. doi: 10.1039/d1ay00070e. Epub 2021 
      Mar 3.