PMID- 33657268
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20211015
IS  - 2050-4527 (Electronic)
IS  - 2050-4527 (Linking)
VI  - 9
IP  - 2
DP  - 2021 Jun
TI  - Current research status of HLA in immune-related diseases.
PG  - 340-350
LID - 10.1002/iid3.416 [doi]
AB  - Human leukocyte antigen (HLA), also known as human major histocompatibility 
      complex (MHC), is encoded by the HLA gene complex, and is currently known to have 
      the highest gene density and the most polymorphisms among human chromosomal 
      areas. HLA is divided into class I antigens, class II antigens, and class III 
      antigens according to distribution and function. Classical HLA class I antigens 
      include HLA-A, HLA-B, and HLA-C; HLA class II antigens include HLA-DP, HLA-DQ, 
      and HLA-DR; nonclassical HLA class I and II molecules include HLA-F, E, H, X, DN, 
      DO, and DM; and others, such as complement, are class III antigens. HLA is 
      closely related to the body's immune response, regulation, and surveillance and 
      is of great significance in the study of autoimmune diseases, tumor immunity, 
      organ transplantation, and reproductive immunity. HLA is an important research 
      topic that bridges immunology and clinical diseases. With the development of 
      research methods and technologies, there will be more discoveries and broader 
      prospects.
CI  - (c) 2021 The Authors. Immunity, Inflammation and Disease published by John Wiley & 
      Sons Ltd.
FAU - Liu, Bingnan
AU  - Liu B
AUID- ORCID: 0000-0002-1938-4679
AD  - Department of Hematology, Tianjin Medical University General Hospital, Tianjin, 
      PR China.
FAU - Shao, Yuanyuan
AU  - Shao Y
AD  - Department of Hematology, Tianjin Medical University General Hospital, Tianjin, 
      PR China.
FAU - Fu, Rong
AU  - Fu R
AD  - Department of Hematology, Tianjin Medical University General Hospital, Tianjin, 
      PR China.
LA  - eng
GR  - 81800119/National Natural Science Foundation of China/
GR  - 81800120/National Natural Science Foundation of China/
GR  - 81870101/National Natural Science Foundation of China/
GR  - 81900125/National Natural Science Foundation of China/
GR  - 81970115/National Natural Science Foundation of China/
GR  - 81970116/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210303
PL  - England
TA  - Immun Inflamm Dis
JT  - Immunity, inflammation and disease
JID - 101635460
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - HLA Antigens/genetics
MH  - *HLA-DP Antigens
MH  - HLA-DR Antigens
MH  - Histocompatibility Antigens Class I
MH  - *Histocompatibility Antigens Class II
MH  - Humans
PMC - PMC8127548
OTO - NOTNLM
OT  - HLA
OT  - MHC
OT  - immune-related diseases
EDAT- 2021/03/04 06:00
MHDA- 2021/10/16 06:00
PMCR- 2021/03/03
CRDT- 2021/03/03 17:11
PHST- 2021/02/13 00:00 [revised]
PHST- 2021/01/22 00:00 [received]
PHST- 2021/02/16 00:00 [accepted]
PHST- 2021/03/04 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2021/03/03 17:11 [entrez]
PHST- 2021/03/03 00:00 [pmc-release]
AID - IID3416 [pii]
AID - 10.1002/iid3.416 [doi]
PST - ppublish
SO  - Immun Inflamm Dis. 2021 Jun;9(2):340-350. doi: 10.1002/iid3.416. Epub 2021 Mar 3.