PMID- 33657520
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20220531
IS  - 2211-0356 (Electronic)
IS  - 2211-0348 (Linking)
VI  - 50
DP  - 2021 May
TI  - Class II HLA (DRB1, & DQB1) alleles and IL7R (rs6897932) variants and the risk 
      for Multiple Sclerosis in Kerala, India.
PG  - 102848
LID - S2211-0348(21)00114-0 [pii]
LID - 10.1016/j.msard.2021.102848 [doi]
AB  - BACKGROUND: Different human leukocyte antigen (HLA) variants are known to 
      modulate the risk of multiple sclerosis. The main objective of this study was to 
      identify HLA-DRB1 and HLA-DQB1 alleles and Non -HLA gene IL7R (rs6897932) 
      variants associated with MS. METHODS: Patients attending the MS clinic, diagnosed 
      with Multiple Sclerosis as per Mc Donald diagnostic criteria were the subjects in 
      the study. The association of the highly polymorphic HLA-DRB1 and HLA-DQB1 loci 
      was determined by high resolution tissue typing and the genotyping of the IL7R 
      (rs6897932) variants was performed by Sanger sequencing in MS patients (n = 81) 
      and healthy individuals (n = 82). RESULTS: HLA-DRB1*15:01/15:02 alleles 
      (OR = 3.65; p< 0.0001) and HLA-DQB1*06:02 (OR=4.19, p<0.0001) were found to be 
      positively associated while HLA-DRB1*14:04:01 (OR = 0.21; p = 0.0009) was found 
      to be negatively associated with MS. The most significant predisposing HLA 
      haplotype was found to be DRB1*15:01-DQB1*06:02 (OR=5.69, p<0.0001). Univariate 
      analysis of IL7R SNP (rs6897932) showed no significant association with MS in our 
      population whereas analysis of HLA-DRB1 alleles and IL7R (rs6897932) genotypes 
      showed significant association between the HLA-DRB1*15:01/15:02 and the IL7R 
      (rs6897932) CC genotype (OR = 3.58, p = 0.0002). CONCLUSION: HLA-DRB1*15:01, 
      15:02 and DQB1*06:02 are the predisposing alleles while HLA-DRB1*14:04 is the 
      protective allele for MS in our population.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Vinoy, Navia
AU  - Vinoy N
AD  - Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, 
      Ponekkara, Kochi, Kerala 682041, India.
FAU - Sheeja, Neethu
AU  - Sheeja N
AD  - Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, 
      Ponekkara, Kochi, Kerala 682041, India.
FAU - Kumar, Suresh
AU  - Kumar S
AD  - Department of Neurology, Amrita Institute of Medical Sciences and Research 
      Centre, Amrita Vishwa Vidyapeetham, Kochi, Kerala 682041, India. Electronic 
      address: rsureshkumar@aims.amrita.edu.
FAU - Biswas, Lalitha
AU  - Biswas L
AD  - Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, 
      Ponekkara, Kochi, Kerala 682041, India. Electronic address: 
      lalithabiswas@aims.amrita.edu.
LA  - eng
PT  - Journal Article
DEP - 20210220
PL  - Netherlands
TA  - Mult Scler Relat Disord
JT  - Multiple sclerosis and related disorders
JID - 101580247
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (IL7R protein, human)
RN  - 0 (Interleukin-7 Receptor alpha Subunit)
SB  - IM
MH  - Alleles
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - *HLA-DQ beta-Chains/genetics
MH  - *HLA-DRB1 Chains/genetics
MH  - Haplotypes
MH  - Humans
MH  - India
MH  - Interleukin-7 Receptor alpha Subunit/*genetics
MH  - *Multiple Sclerosis/genetics
OTO - NOTNLM
OT  - HLA-DQB1 alleles
OT  - HLA-DRB1 alleles
OT  - IL7R (rs6897932) variants
OT  - Multiple Sclerosis
OT  - Predisposing HLA allele
OT  - Protective HLA allele
EDAT- 2021/03/04 06:00
MHDA- 2021/05/15 06:00
CRDT- 2021/03/03 20:08
PHST- 2020/12/24 00:00 [received]
PHST- 2021/02/04 00:00 [revised]
PHST- 2021/02/17 00:00 [accepted]
PHST- 2021/03/04 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2021/03/03 20:08 [entrez]
AID - S2211-0348(21)00114-0 [pii]
AID - 10.1016/j.msard.2021.102848 [doi]
PST - ppublish
SO  - Mult Scler Relat Disord. 2021 May;50:102848. doi: 10.1016/j.msard.2021.102848. 
      Epub 2021 Feb 20.