PMID- 33658784
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240331
IS  - 1176-6328 (Print)
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 17
DP  - 2021
TI  - Peripheral Polyneuropathy and Cognitive Impairment in Type II Diabetes Mellitus.
PG  - 627-635
LID - 10.2147/NDT.S284308 [doi]
AB  - BACKGROUND: Neuropathy is one of most common complications in diabetic patients. 
      Diagnosis of diabetic neuropathy is essential for decreasing the rate of the 
      disability and death. Neuron-specific enolase (NSE) is released from damaged 
      neuronal cells and enters the blood circulation through an injured blood brain 
      barrier. Therefore, serum NSE can reflect the damage of neurons and brain tissue. 
      OBJECTIVE: To evaluate peripheral polyneuropathy and cognitive function in Type 2 
      Diabetes Mellitus (T2DM) and correlate them with NSE level as a possible 
      biomarker of diabetic neuropathy. SUBJECTS AND METHODS: Forty five T2DM patients 
      with polyneuropathy were randomly recruited in this study compared to 45 healthy 
      age and sex matched subjects as a control. Patients group were divided into two 
      subgroups, 24 diabetic patients with painful peripheral neuropathy and 21 with 
      painless peripheral neuropathy. All were subjected to clinical assessment by 
      diabetic neuropathy symptom score, Dyck neuropathy grading, Mini-Mental State 
      Examination (MMSE), assessment of HbA1c, NSE biomarker and neurophysiological 
      assessment (nerve conduction study (NCS), event related potential (P300wave) and 
      somatosensory evoked potential (SSEP) of the right median nerve). RESULTS: There 
      were significant decrease in cognitive functions in diabetic patients compared to 
      controls and a significant increase in NSE in diabetic patients. There were no 
      significant difference between patients with painless and painful diabetic 
      neuropathy as regard MMSE, HbA1c and NSE. There were significant correlation of 
      P300 in diabetic patients with HbA1c and NSE. CONCLUSION: Neurophysiological 
      assessment of diabetic patients by NCS, SSEP and P300 have well evaluation of 
      cognitive functions, painless, and painful diabetic polyneuropathy. NSE is a 
      beneficial biomarker in diabetic patients to pick up neurological complications.
CI  - (c) 2021 Elsharkawy et al.
FAU - Elsharkawy, Rasha Elbialy
AU  - Elsharkawy RE
AD  - Department of Neurology, Faculty of Medicine for Girls, Al-Azhar University, 
      Cairo, Egypt.
FAU - Abdel Azim, Ghada Saed
AU  - Abdel Azim GS
AUID- ORCID: 0000-0002-2289-3802
AD  - Department of Neurology, Faculty of Medicine for Girls, Al-Azhar University, 
      Cairo, Egypt.
FAU - Osman, Marwa Abdellah
AU  - Osman MA
AD  - Department of Neurology, Faculty of Medicine for Girls, Al-Azhar University, 
      Cairo, Egypt.
FAU - Maghraby, Hend Maghraby
AU  - Maghraby HM
AUID- ORCID: 0000-0001-7224-2242
AD  - Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar 
      University, Cairo, Egypt.
FAU - Mohamed, Rehab Abdelfattah
AU  - Mohamed RA
AUID- ORCID: 0000-0003-0760-5013
AD  - Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar 
      University, Cairo, Egypt.
FAU - Abdelsalam, Eman Mahmoud
AU  - Abdelsalam EM
AUID- ORCID: 0000-0001-9695-0470
AD  - Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar 
      University, Cairo, Egypt.
FAU - Ebrahem, Eman Elshohat
AU  - Ebrahem EE
AD  - Department of Biochemistry, Faculty of Medicine for Girls, Al-Azhar University, 
      Cairo, Egypt.
FAU - Seliem, Nora Mohamed Ahmed
AU  - Seliem NMA
AUID- ORCID: 0000-0001-9541-6479
AD  - Department of Biochemistry, Faculty of Medicine for Girls, Al-Azhar University, 
      Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20210224
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC7917357
OTO - NOTNLM
OT  - MMSE
OT  - Mini-Mental State Examination
OT  - NSE
OT  - diabetic neuropathy
OT  - glycated hemoglobin
OT  - nerve conduction study
OT  - neuron-specific enolase
COIS- The authors declared no conflicts of interest in this work.
EDAT- 2021/03/05 06:00
MHDA- 2021/03/05 06:01
PMCR- 2021/02/24
CRDT- 2021/03/04 05:53
PHST- 2020/10/03 00:00 [received]
PHST- 2020/12/24 00:00 [accepted]
PHST- 2021/03/04 05:53 [entrez]
PHST- 2021/03/05 06:00 [pubmed]
PHST- 2021/03/05 06:01 [medline]
PHST- 2021/02/24 00:00 [pmc-release]
AID - 284308 [pii]
AID - 10.2147/NDT.S284308 [doi]
PST - epublish
SO  - Neuropsychiatr Dis Treat. 2021 Feb 24;17:627-635. doi: 10.2147/NDT.S284308. 
      eCollection 2021.