PMID- 33658818
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220421
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 14
DP  - 2021
TI  - A Clinical Epidemiological Analysis of Prognostic Nutritional Index Associated 
      with Diabetic Retinopathy.
PG  - 839-846
LID - 10.2147/DMSO.S295757 [doi]
AB  - PURPOSE: Prognostic nutritional index (PNI) is an effective tool to evaluate the 
      nutritional conditions and predict prognosis, but clinical data are limited for 
      the use of PNI in diabetic retinopathy (DR). This study aimed to investigate the 
      relationship of PNI with the prevalence and severity of DR in patients with type 
      2 diabetes mellitus (T2DM). PATIENTS AND METHODS: This cross-sectional analysis 
      enrolled 1023 individuals with T2DM hospitalized between 2017-2020. PNI was 
      calculated as 10 x serum albumin (g/l) + 0.005 x total lymphocyte count 
      (cells/mL). DR severity was categorized as no, nonproliferative, and 
      vision-threatened DR (VTDR) according to the modified Airlie House 
      classification. Multivariate-adjusted odds ratio (OR) with 95% confidence 
      interval (CI) for the prevalent DR in the top (Q4) compared with the bottom 
      quartile (Q1) of PNI levels were estimated by using logistic regression analyses. 
      RESULTS: PNI levels were significantly lower in individuals with VTDR than those 
      with no and nonproliferative DR (both P < 0.001), and the proportions of 
      individuals with DR were significantly decreased in the top quartile compared 
      with the bottom quartile of PNI levels (P < 0.001). After adjustments for age, 
      gender, DM duration, obesity-related risk factors and clinical biochemical 
      parameters, the higher levels of PNI were significantly associated with a lower 
      prevalence of DR (Q4 vs Q1: OR = 0.402, 95% CI: 0.250-0.649, P < 0.001), with a 
      5.9% reduction in the prevalence of DR for a per-unit increment in the levels of 
      PNI (OR = 0.941, 95% CI: 0.911-0.972, P < 0.001). The association of PNI and 
      obesity-related indexes (body mass index and waist circumference) with the 
      severity of DR was independent of each other (P<0.001). CONCLUSION: PNI was 
      inversely and independently associated with the severity and prevalence of DR, 
      which suggested that PNI could likely be used to predict DR prognosis in clinical 
      practice.
CI  - (c) 2021 Yang et al.
FAU - Yang, Lijuan
AU  - Yang L
AD  - Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People's Republic 
      of China.
FAU - Yu, Weihui
AU  - Yu W
AD  - Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People's Republic 
      of China.
FAU - Pan, Wei
AU  - Pan W
AD  - Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People's Republic 
      of China.
FAU - Chen, Shuoping
AU  - Chen S
AD  - Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People's Republic 
      of China.
FAU - Ye, Xiwen
AU  - Ye X
AD  - Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People's Republic 
      of China.
FAU - Gu, Xuejiang
AU  - Gu X
AD  - Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People's Republic 
      of China.
FAU - Hu, Xiang
AU  - Hu X
AD  - Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People's Republic 
      of China.
LA  - eng
PT  - Journal Article
DEP - 20210225
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC7920509
OTO - NOTNLM
OT  - diabetic retinopathy
OT  - obesity
OT  - prognostic nutritional index
OT  - type 2 diabetes mellitus
COIS- The authors report no conflicts of interest in this work.
EDAT- 2021/03/05 06:00
MHDA- 2021/03/05 06:01
PMCR- 2021/02/25
CRDT- 2021/03/04 05:53
PHST- 2020/12/07 00:00 [received]
PHST- 2021/02/03 00:00 [accepted]
PHST- 2021/03/04 05:53 [entrez]
PHST- 2021/03/05 06:00 [pubmed]
PHST- 2021/03/05 06:01 [medline]
PHST- 2021/02/25 00:00 [pmc-release]
AID - 295757 [pii]
AID - 10.2147/DMSO.S295757 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2021 Feb 25;14:839-846. doi: 10.2147/DMSO.S295757. 
      eCollection 2021.