PMID- 33659190
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210305
IS  - 2214-7500 (Electronic)
IS  - 2214-7500 (Linking)
VI  - 8
DP  - 2021
TI  - Toxicity and bioaccumulation of manganese and chromium in different organs of 
      common carp (Cyprinus carpio) fish.
PG  - 343-348
LID - 10.1016/j.toxrep.2021.02.003 [doi]
AB  - The present research work was carried out to determine the bioaccumulation of 
      manganese and chromium in the gills, intestine, muscles, skin and bones, as well 
      as its acute toxicity and effects on hematological and biochemical parameters in 
      Common carp (Cyprinus carpio). Adult carps were exposed for 96 h to manganese 
      sulphate and chromium chloride solution, a sub lethal concentration was used in 
      the experiment. Bioaccumulation was highest in the gills followed by 
      intestine > muscles > skin > bones. The concentration of hematocrit (HCT) 
      (37.3 +/- 0.36), hemoglobin (HGB) (9.0 +/- 0.04), Red Blood Cells (RBCs) 
      (3.7 +/- 0.025), mean corpuscular volume (MCV) (121.2 +/- 0.36), mean corpuscular 
      hemoglobin (MCH) (41.3 +/- 0.3) and mean corpuscular hemoglobin concentration 
      (MCHC) (41.06 +/- 0.072) was significantly higher at 96 h (P < 0.01) after exposure 
      to manganese and chromium, while the concentration of platelets (PLT) 
      (16.8 +/- 0.12) and white blood cells (WBCs) (62.7 +/- 0.11) was lower at 96 h of 
      exposure. Serum glutamic pyruvic transaminase (SGPT) (40.6 +/- 0.4), Blood Urea 
      (13 +/- 0.1), serum triglycerides (231.21 +/- 0.04), high-density lipoprotein (HDL) 
      (39 +/- 0.07), serum Alkaline PO(4) (242 +/- 0.2), lactate dehydrogenase (LDH) 
      (1239 +/- 13.21), and serum Uric Acid (4.81 +/- 0.33) were significantly higher 
      (P < 0.01) at 96 h of exposure. The highest concentration of serum cholesterol 
      (339 +/- 0.09), serum reatinine (0.9 +/- 0.01), low density lipid (240 +/- 0.2) was 
      observed at 24 h. Serum glutamic-oxaloacetic transaminase (SGOT) (19 +/- 0.13), and 
      serum albumin were at the highest level at 72 h (3.19 +/- 0.07) (P < 0.01) post 
      exposure.
CI  - (c) 2021 The Author(s).
FAU - Ali, Zeeshan
AU  - Ali Z
AD  - Department of Zoology, Islamia College University Peshawar, Pakistan.
FAU - Yousafzai, Ali Muhammad
AU  - Yousafzai AM
AD  - Department of Zoology, Islamia College University Peshawar, Pakistan.
FAU - Sher, Nadia
AU  - Sher N
AD  - Department of Chemistry, Islamia College University Peshawar, Pakistan.
FAU - Muhammad, Ijaz
AU  - Muhammad I
AD  - Department of Zoology, Abdul Wali Khan University, Mardan, 23200, Pakistan.
FAU - Nayab, Gul E
AU  - Nayab GE
AD  - Department of Zoology, Abdul Wali Khan University, Mardan, 23200, Pakistan.
FAU - Aqeel, Syed Abdul Maajid
AU  - Aqeel SAM
AD  - Department of Zoology, Islamia College University Peshawar, Pakistan.
FAU - Shah, Syed Touheed
AU  - Shah ST
AD  - Department of Zoology, Islamia College University Peshawar, Pakistan.
FAU - Aschner, Michael
AU  - Aschner M
AD  - Department of Molecular Pharmacology, Albert Einstein College of Medicine 
      Forchheimer, 209 1300 Morris Park Avenue Bronx, NY, 10461, United States.
FAU - Khan, Ijaz
AU  - Khan I
AD  - Department of Microbiology, Hazara University Mansehra, Pakistan.
FAU - Khan, Haroon
AU  - Khan H
AD  - Department of Pharmacy, Abdul Wali Khan University, Mardan, 23200, Pakistan.
LA  - eng
PT  - Journal Article
DEP - 20210206
PL  - Ireland
TA  - Toxicol Rep
JT  - Toxicology reports
JID - 101630272
PMC - PMC7896127
OTO - NOTNLM
OT  - Bioaccumulation
OT  - Chromium
OT  - Cyprinus carpio
OT  - HCT, Hematocrit
OT  - HDL, High-density lipoprotein
OT  - HGB, Hemoglobin
OT  - Heavy metal
OT  - LDH, Lactate dehydrogenase
OT  - MCH, Mean corpuscular hemoglobin
OT  - MCHC, Mean corpuscular hemoglobin concentration
OT  - MCV, Mean corpuscular volume
OT  - Manganese
OT  - PLT, Platelets
OT  - RBCs, Red Blood Cells
OT  - SGOT, Serum glutamic-oxaloacetic transaminase
OT  - SGPT, Serum glutamic pyruvic transaminase
OT  - WBCs, White blood cells
COIS- The authors report no declarations of interest.
EDAT- 2021/03/05 06:00
MHDA- 2021/03/05 06:01
PMCR- 2021/02/06
CRDT- 2021/03/04 05:55
PHST- 2020/10/11 00:00 [received]
PHST- 2021/02/02 00:00 [revised]
PHST- 2021/02/04 00:00 [accepted]
PHST- 2021/03/04 05:55 [entrez]
PHST- 2021/03/05 06:00 [pubmed]
PHST- 2021/03/05 06:01 [medline]
PHST- 2021/02/06 00:00 [pmc-release]
AID - S2214-7500(21)00020-2 [pii]
AID - 10.1016/j.toxrep.2021.02.003 [doi]
PST - epublish
SO  - Toxicol Rep. 2021 Feb 6;8:343-348. doi: 10.1016/j.toxrep.2021.02.003. eCollection 
      2021.