PMID- 33659270
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210305
IS  - 2296-875X (Print)
IS  - 2296-875X (Electronic)
IS  - 2296-875X (Linking)
VI  - 7
DP  - 2020
TI  - Xingbi Gel Ameliorates Allergic Rhinitis by Regulating IFN-gamma Gene Promoter 
      Methylation in CD4+ T Cells via the ERK-DNMT Pathway.
PG  - 619053
LID - 10.3389/fsurg.2020.619053 [doi]
LID - 619053
AB  - Allergic rhinitis (AR) is a common, non-infectious, chronic nasal mucosal disease 
      primarily mediated by immunoglobulin E (IgE) following allergen exposure. 
      Currently, studies on AR mainly focus on cytokines, IgE and its receptors, 
      basophils, eosinophils, mast cells, and related genes. Among these, an imbalance 
      between T helper (Th) 1 and Th2 cells is considered an important mechanism 
      underlying AR pathogenesis. The most important cytokines in AR are interleukin 
      (Il)-4 and interferon gamma (IFN-gamma) which are secreted by Th2 and Th1 cells, 
      respectively. Il-4 and IFN-gamma are antagonistic to each other in regulating IgE 
      synthesis. In this study, the expression of extracellular signal-regulated 
      protein kinase (ERK) 1/2 and its phosphorylation from p-ERK1/2, were 
      significantly increased in a cluster of differentiation of 4+ T cells of AR mice, 
      suggesting that the ERK signaling pathway in these cells is involved in the 
      occurrence and development of AR. This result also implies an enhanced expression 
      of deoxyribonucleic acid methyltransferases (DNMTs). To verify the relationship 
      between ERK signaling and DNMT expression, AR mice were treated with PD98059, a 
      specific inhibitor of the ERK1/2 signaling pathway. The results revealed that 
      perturbations in ERK signaling were significantly positively correlated with the 
      downregulation of DNMT1 expression. Pharmacological intervention is key to 
      treating AR. This study demonstrated that Xingbi gel intervention affected both 
      serum IgE levels and AR behavior scores in mice. Based on its effects on IFN-gamma 
      gene expression, the regulation of Th1/Th2 balance, and the ERK signaling 
      pathway, research on the effects of Xingbi gel on AR may provide new avenues in 
      its prevention and treatment.
CI  - Copyright (c) 2021 Ai, Lin, Zheng and Zhuang.
FAU - Ai, Si
AU  - Ai S
AD  - The Affiliated People's Hospital of Fujian University of Traditional Chinese 
      Medicine, Fuzhou, China.
FAU - Lin, Yueyong
AU  - Lin Y
AD  - No. 900 Hospital of the Joint Logistics Support Force of the Chinese People's 
      Liberation Army, Fuzhou, China.
FAU - Zheng, Jian
AU  - Zheng J
AD  - Fujian University of Traditional Chinese Medicine, Fuzhou, China.
FAU - Zhuang, Xiangli
AU  - Zhuang X
AD  - Fujian University of Traditional Chinese Medicine, Fuzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20210215
PL  - Switzerland
TA  - Front Surg
JT  - Frontiers in surgery
JID - 101645127
PMC - PMC7917250
OTO - NOTNLM
OT  - CD4+ T cells
OT  - ERK signaling pathway
OT  - Xingbi gel
OT  - allergic rhinitis
OT  - methylation
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/03/05 06:00
MHDA- 2021/03/05 06:01
PMCR- 2021/02/15
CRDT- 2021/03/04 05:55
PHST- 2020/10/19 00:00 [received]
PHST- 2020/12/29 00:00 [accepted]
PHST- 2021/03/04 05:55 [entrez]
PHST- 2021/03/05 06:00 [pubmed]
PHST- 2021/03/05 06:01 [medline]
PHST- 2021/02/15 00:00 [pmc-release]
AID - 10.3389/fsurg.2020.619053 [doi]
PST - epublish
SO  - Front Surg. 2021 Feb 15;7:619053. doi: 10.3389/fsurg.2020.619053. eCollection 
      2020.