PMID- 33660270
OWN - NLM
STAT- MEDLINE
DCOM- 20210806
LR  - 20210806
IS  - 1748-5827 (Electronic)
IS  - 0022-4510 (Linking)
VI  - 62
IP  - 7
DP  - 2021 Jul
TI  - Clinical characteristics and long-term outcome of E. coli-associated 
      granulomatous ileocolitis in dogs: five cases (2010-2014).
PG  - 588-598
LID - 10.1111/jsap.13313 [doi]
AB  - OBJECTIVES: To describe the clinical characteristics and long-term outcome of 
      Escherichia coli-associated granulomatous ileocolitis in dogs. METHODS: 
      Retrospective review of medical records from dogs with periodic acid-Schiff 
      positive (PAS+) granulomatous ileocolitis and mucosally invasive E. coli in the 
      ileum and colon. Initial bacterial colonisation was evaluated using fluorescence 
      in situ hybridization (FISH) in all dogs and corroborated with colonic and/or 
      ileal culture, when performed. RESULTS: Four boxer dogs and 1 French Bulldog with 
      PAS+ granulomatous ileocolitis (GIC) were evaluated. All dogs had chronic 
      diarrhoea refractory to empirical therapy. Ileocolonoscopy revealed mucosal 
      haemorrhage and ulceration in the ileum (3/4) and colon (5/5). E. coli were 
      visualised as clusters within the ileal and colonic mucosa. Complete (CR, 4/5) or 
      partial (PR, 1/5) clinical response to fluoroquinolones was noted in all dogs 
      within 30 days. CR was sustained in three of four dogs (median disease-free 
      interval 40 months, range 16 to 60). Two dogs relapsed while receiving 
      fluoroquinolones. Repeat biopsy isolated multidrug-resistant, mucosally invasive 
      E. coli in the ileum (1/2) and colon (2/2). Targeted antimicrobial therapy was 
      associated with long-term PR (78 months) in both dogs. CLINICAL SIGNIFICANCE: 
      Concurrent E. coli-associated granulomatous inflammation in the ileum and colon 
      did not impart a poor clinical outcome or lack of response to the conventional 
      standard of care for granulomatous colitis in dogs that were aggressively 
      diagnosed and treated. Clinical outcome was influenced by antimicrobial 
      resistance, with response dependent upon antimicrobial therapy informed by 
      susceptibility testing.
CI  - (c) 2021 British Small Animal Veterinary Association.
FAU - Cochran, L
AU  - Cochran L
AD  - Department of Internal Medicine, Veterinary Specialty Hospital of San Diego by 
      Ethos, San Diego, California, 92121, USA.
FAU - Hill, S
AU  - Hill S
AD  - Department of Internal Medicine, Veterinary Specialty Hospital of San Diego, San 
      Diego, California, 92121, USA.
FAU - Lotti, U
AU  - Lotti U
AD  - Clinica Veterinaria Valdinievole Srl, Via Costantino Nigra, Monsummano Terme 
      (PT), Italy.
FAU - Allenspach, K
AU  - Allenspach K
AD  - Veterinary Clinical Sciences, Iowa State University College of Veterinary 
      Medicine, Ames, Iowa, 50011-1134, USA.
AD  - Department of Veterinary Clinical Sciences and Services, Royal Veterinary 
      College, University of London, Hawshead Lane, North Mymms, Hatfield, AL9 7TA, UK.
FAU - Palma, D
AU  - Palma D
AD  - Department of Internal Medicine, Animal Medical Center, New York, New York, 
      10065, USA.
FAU - Forman, M
AU  - Forman M
AD  - Department of Internal Medicine, Cornell University Veterinary Specialists, 
      Stamford, Connecticut, 06902, USA.
FAU - Gary, A T
AU  - Gary AT
AD  - Arkansas Veterinary Internal Medicine, 2150 Bypass Road, Heber Springs, Arkansas, 
      72543, USA.
FAU - Dogan, B
AU  - Dogan B
AD  - Department of Clinical Sciences, Cornell University College of Veterinary 
      Medicine, 930 Campus Road, Ithaca, New York, 14853, USA.
FAU - McDonough, S P
AU  - McDonough SP
AD  - Department of Biomedical Sciences, Cornell University College of Veterinary 
      Medicine, T8 008A Veterinary Research Tower, Box 17 Ithaca, New York, 14853-6401, 
      USA.
FAU - Simpson, K W
AU  - Simpson KW
AD  - Department of Clinical Sciences, Cornell University College of Veterinary 
      Medicine, 930 Campus Road, Ithaca, New York, 14853, USA.
LA  - eng
PT  - Journal Article
DEP - 20210303
PL  - England
TA  - J Small Anim Pract
JT  - The Journal of small animal practice
JID - 0165053
SB  - IM
MH  - Animals
MH  - *Crohn Disease/veterinary
MH  - *Dog Diseases/drug therapy
MH  - Dogs
MH  - Escherichia coli
MH  - *Escherichia coli Infections/drug therapy/veterinary
MH  - In Situ Hybridization, Fluorescence/veterinary
MH  - Retrospective Studies
EDAT- 2021/03/05 06:00
MHDA- 2021/08/07 06:00
CRDT- 2021/03/04 06:01
PHST- 2020/12/16 00:00 [revised]
PHST- 2020/05/28 00:00 [received]
PHST- 2021/01/09 00:00 [accepted]
PHST- 2021/03/05 06:00 [pubmed]
PHST- 2021/08/07 06:00 [medline]
PHST- 2021/03/04 06:01 [entrez]
AID - 10.1111/jsap.13313 [doi]
PST - ppublish
SO  - J Small Anim Pract. 2021 Jul;62(7):588-598. doi: 10.1111/jsap.13313. Epub 2021 
      Mar 3.