PMID- 33660574
OWN - NLM
STAT- MEDLINE
DCOM- 20220211
LR  - 20221207
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 46
IP  - 10
DP  - 2021 Oct
TI  - Association between Hyperhomocysteinemia and Hypertensive Retinopathy in a 
      Chinese Han Population.
PG  - 1539-1543
LID - 10.1080/02713683.2021.1894581 [doi]
AB  - Purpose/aim: In some diseases, hyperhomocysteinemia (HHcy) has been recognized as 
      a risk factor. However, information on the correlation between HHcy and 
      hypertensive retinopathy (HR) in the Chinese population is unclear. We, 
      therefore, aimed to investigate this association.Materials and Methods: A total 
      of 382 patients were collected and 126 individuals were excluded in this study. 
      Finally, 128 patients with HR and 128 control subjects were enrolled 
      sequentially. The association between HHcy and the occurrence of HR was 
      determined by multivariate logistic regression analysis, including interaction 
      and stratified analyses.Results: HHcy, cardiovascular disease, fasting blood 
      glucose, creatinine, triglyceride, diabetes, smoking habits, drinking habits were 
      significantly associated with HR (P < .05) in the univariate logistic regression 
      analysis. Each increase of 1 mumol/L of homocysteine concentration was 
      significantly correlated with a 9% increased risk of HR (odds ratio [OR] = 1.09, 
      95% confidence interval [CI]: 1.07-1.55, P < .05). Hierarchical analysis 
      identified history of diabetes (OR = 7.38, P > .05), age >/=60 years (OR = 3.08, P 
      > .05), male sex (OR = 1.04, P > .05), history of cardiovascular disease 
      (OR = 7.88, P > .05), smoking habit (OR = 1.08, P > .05), and drinking habit 
      (OR = 78.31, P > .05), as factors associated with HR, but not as independent risk 
      factors for HR. Interaction analysis demonstrated no interaction between HHcy and 
      HR.Conclusions: Within the Chinese Han population, HHcy is an independent risk 
      factor for HR.
FAU - Zhong, Ze-Long
AU  - Zhong ZL
AD  - Department of Vitreoretinopathy, Tianjin Eye Hospital, Tianjin, China.
AD  - Department of Vitreoretinopathy, Nankai University Affiliated Eye Hospital, 
      Tianjin, China.
AD  - Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.
FAU - Liu, Jie
AU  - Liu J
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210304
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
RN  - 0 (Blood Glucose)
RN  - 0 (Triglycerides)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Aged
MH  - Asian People/*ethnology
MH  - Blood Glucose/metabolism
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Creatinine/blood
MH  - Female
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/*epidemiology
MH  - Hypertensive Retinopathy/*epidemiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Risk Factors
MH  - Triglycerides/blood
OTO - NOTNLM
OT  - Homocysteine
OT  - Hyperhomocysteinemia
OT  - Hypertensive retinopathy
OT  - case-control study
OT  - risk factor
EDAT- 2021/03/05 06:00
MHDA- 2022/02/12 06:00
CRDT- 2021/03/04 08:39
PHST- 2021/03/05 06:00 [pubmed]
PHST- 2022/02/12 06:00 [medline]
PHST- 2021/03/04 08:39 [entrez]
AID - 10.1080/02713683.2021.1894581 [doi]
PST - ppublish
SO  - Curr Eye Res. 2021 Oct;46(10):1539-1543. doi: 10.1080/02713683.2021.1894581. Epub 
      2021 Mar 4.