PMID- 33665348
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2352-8729 (Print)
IS  - 2352-8729 (Electronic)
IS  - 2352-8729 (Linking)
VI  - 13
IP  - 1
DP  - 2021
TI  - Body weight changes and longitudinal associations with cognitive decline among 
      community-dwelling older adults.
PG  - e12163
LID - 10.1002/dad2.12163 [doi]
LID - e12163
AB  - INTRODUCTION: We aim to investigate the longitudinal associations between changes 
      in body weight (BW) and declines in cognitive function and risk of mild cognitive 
      impairment (MCI)/dementia among cognitively normal individuals 65 years or older. 
      METHODS: Data from the Age Gene/Environment Susceptibility-Reykjavik Study 
      (AGES-Reykjavik Study) including 2620 participants, were examined using multiple 
      logistic regression models. Cognitive function included speed of processing (SP), 
      executive function (EF), and memory function (MF). Changes in BW were classified 
      as; weight loss (WL), weight gain (WG), and stable weight (SW). RESULTS: Mean 
      follow-up time was 5.2 years and 61.3% were stable weight. Participants who 
      experienced WL (13.4%) were significantly more likely to have declines in MF and 
      SP compared to the SW group. Weight changes were not associated with EF. WL was 
      associated with a higher risk of MCI, while WG (25.3%) was associated with a 
      higher dementia risk, when compared to SW. DISCUSSION: Significant BW changes in 
      older adulthood may indicate impending changes in cognitive function.
CI  - (c) 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease 
      Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's 
      Association.
FAU - Eymundsdottir, Hrafnhildur
AU  - Eymundsdottir H
AD  - Food Science and Nutrition University of Iceland Reykjavik Iceland.
AD  - The Icelandic Gerontological Research Center the National University Hospital of 
      Iceland Reykjavik Iceland.
FAU - Ramel, Alfons
AU  - Ramel A
AD  - Food Science and Nutrition University of Iceland Reykjavik Iceland.
AD  - The Icelandic Gerontological Research Center the National University Hospital of 
      Iceland Reykjavik Iceland.
FAU - Geirsdottir, Olof G
AU  - Geirsdottir OG
AD  - Food Science and Nutrition University of Iceland Reykjavik Iceland.
AD  - The Icelandic Gerontological Research Center the National University Hospital of 
      Iceland Reykjavik Iceland.
FAU - Skuladottir, Sigrun S
AU  - Skuladottir SS
AD  - Food Science and Nutrition University of Iceland Reykjavik Iceland.
AD  - The Icelandic Gerontological Research Center the National University Hospital of 
      Iceland Reykjavik Iceland.
FAU - Gudmundsson, Larus S
AU  - Gudmundsson LS
AD  - Pharmaceutical Sciences School of Health Sciences University of Iceland Iceland.
FAU - Jonsson, Palmi V
AU  - Jonsson PV
AD  - The Icelandic Gerontological Research Center the National University Hospital of 
      Iceland Reykjavik Iceland.
AD  - Medicine University of Iceland Reykjavik Iceland.
AD  - Department of Geriatrics the National University Hospital of Iceland Reykjavik 
      Iceland.
FAU - Gudnason, Vilmundur
AU  - Gudnason V
AD  - Medicine University of Iceland Reykjavik Iceland.
AD  - Icelandic Heart Association Kopavogur Iceland.
FAU - Launer, Lenore
AU  - Launer L
AD  - Laboratory of Epidemiology and Population Sciences National Institute on Aging 
      National Institutes of Health Bethesda Maryland USA.
FAU - Jonsdottir, Maria K
AU  - Jonsdottir MK
AD  - Department of Psychology Reykjavik University Reykjavik Iceland.
AD  - Mental Health Services Landspitali-The National University Hospital of Iceland 
      Iceland.
FAU - Chang, Milan
AU  - Chang M
AD  - The Icelandic Gerontological Research Center the National University Hospital of 
      Iceland Reykjavik Iceland.
AD  - Health Promotion Sport, and Leisure Studies School of Education University of 
      Iceland Reykjavik Iceland.
LA  - eng
PT  - Journal Article
DEP - 20210220
PL  - United States
TA  - Alzheimers Dement (Amst)
JT  - Alzheimer's & dementia (Amsterdam, Netherlands)
JID - 101654604
PMC - PMC7896555
OTO - NOTNLM
OT  - APOE epsilon4
OT  - body weight changes
OT  - cognitive function
OT  - dementia
OT  - executive function
OT  - memory function
OT  - mild cognitive impairment
OT  - nutrition
OT  - speed of processing
COIS- The authors declare no conflicts of interest.
EDAT- 2021/03/06 06:00
MHDA- 2021/03/06 06:01
PMCR- 2021/02/20
CRDT- 2021/03/05 06:08
PHST- 2021/01/07 00:00 [received]
PHST- 2021/01/21 00:00 [revised]
PHST- 2021/01/26 00:00 [accepted]
PHST- 2021/03/05 06:08 [entrez]
PHST- 2021/03/06 06:00 [pubmed]
PHST- 2021/03/06 06:01 [medline]
PHST- 2021/02/20 00:00 [pmc-release]
AID - DAD212163 [pii]
AID - 10.1002/dad2.12163 [doi]
PST - epublish
SO  - Alzheimers Dement (Amst). 2021 Feb 20;13(1):e12163. doi: 10.1002/dad2.12163. 
      eCollection 2021.