PMID- 33665845
OWN - NLM
STAT- MEDLINE
DCOM- 20210625
LR  - 20220930
IS  - 1939-1676 (Electronic)
IS  - 0891-6640 (Print)
IS  - 0891-6640 (Linking)
VI  - 35
IP  - 2
DP  - 2021 Mar
TI  - Coagulation status, fibrinolysis, and platelet dynamics in dogs with chronic 
      inflammatory enteropathy.
PG  - 892-901
LID - 10.1111/jvim.16092 [doi]
AB  - BACKGROUND: Coagulation status is poorly understood in dogs with chronic 
      inflammatory enteropathy (CIE). Fibrinolytic activity and platelet dynamics have 
      not been evaluated in CIE dogs. OBJECTIVES: To assess coagulation status and 
      fibrinolysis in normoalbuminemic CIE dogs (CIE-N) and CIE dogs with 
      protein-losing enteropathy (CIE-PLE) compared to healthy controls (HC). To 
      evaluate thromboelastography (TEG) variable differences between groups and for 
      correlations with clinicopathologic data. To report platelet dynamics in CIE 
      dogs. ANIMALS: Twenty-five client-owned dogs with CIE (n = 16 CIE-N; n = 9 
      CIE-PLE); 14 HC beagle dogs. METHODS: All dogs had tissue factor + tissue 
      plasminogen activator TEG. Nine of 25 CIE dogs had whole blood impedance platelet 
      aggregometry. The TEG variables and coagulation data were compared between all 
      CIE vs HC dogs, CIE-N dogs vs HC, and CIE-PLE dogs vs HC. Clinicopathologic and 
      coagulation data were available for CIE dogs and assessed for correlation to TEG 
      variables. RESULTS: Dogs with CIE had higher maximum amplitude (MA; P < .001), 
      longer clot lysis times (CLTs; P < .001), lower % lysis after 30 minutes (LY30; 
      P < .001), and % lysis after 60 minutes (LY60; P < .001) compared to HC, 
      suggesting hypercoagulability and hypofibrinolysis. When separated out, both 
      CIE-N and CIE-PLE dogs had higher MA, longer CLT, and lower LY30 and LY60 
      compared to HC. Serum albumin and 25-hydroxyvitamin D (25[OH]D) concentrations, 
      and plasma antithrombin and fibrinogen concentrations moderately correlated with 
      MA. CONCLUSIONS AND CLINICAL IMPORTANCE: Normoalbuminemic and hypoalbuminemic CIE 
      dogs were considered hypercoagulable based on TEG compared to HC. Some CIE dogs 
      displayed hypofibrinolytic phenotypes on TEG.
CI  - (c) 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley 
      Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
FAU - Wennogle, Sara A
AU  - Wennogle SA
AUID- ORCID: 0000-0002-6486-3644
AD  - Department of Clinical Sciences, College of Veterinary Medicine and Biomedical 
      Sciences, Colorado State University, Fort Collins, Colorado, USA.
FAU - Olver, Christine S
AU  - Olver CS
AUID- ORCID: 0000-0002-9937-2706
AD  - Department of Microbiology, Immunology, and Pathology, College of Veterinary 
      Medicine and Biomedical Sciences, Colorado State University, Fort Collins, 
      Colorado, USA.
FAU - Shropshire, Sarah B
AU  - Shropshire SB
AUID- ORCID: 0000-0002-6472-5452
AD  - Department of Clinical Sciences, College of Veterinary Medicine and Biomedical 
      Sciences, Colorado State University, Fort Collins, Colorado, USA.
LA  - eng
PT  - Journal Article
DEP - 20210304
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
SB  - IM
EIN - J Vet Intern Med. 2022 Sep 30;:. PMID: 36178304
MH  - Animals
MH  - Dogs
MH  - Fibrin Clot Lysis Time/veterinary
MH  - *Fibrinolysis
MH  - Prospective Studies
MH  - Thrombelastography/veterinary
MH  - *Tissue Plasminogen Activator
PMC - PMC7995439
OTO - NOTNLM
OT  - coagulation
OT  - enteropathy
OT  - fibrinolysis
OT  - platelet dynamics
OT  - thromboelastography
COIS- Authors declare no conflict of interest.
EDAT- 2021/03/06 06:00
MHDA- 2021/06/29 06:00
PMCR- 2021/03/01
CRDT- 2021/03/05 06:11
PHST- 2021/02/12 00:00 [revised]
PHST- 2020/10/24 00:00 [received]
PHST- 2021/02/19 00:00 [accepted]
PHST- 2021/03/06 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2021/03/05 06:11 [entrez]
PHST- 2021/03/01 00:00 [pmc-release]
AID - JVIM16092 [pii]
AID - 10.1111/jvim.16092 [doi]
PST - ppublish
SO  - J Vet Intern Med. 2021 Mar;35(2):892-901. doi: 10.1111/jvim.16092. Epub 2021 Mar 
      4.