PMID- 33666639
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20210408
LR  - 20210408
IS  - 1477-0539 (Electronic)
IS  - 1477-0520 (Linking)
VI  - 19
IP  - 12
DP  - 2021 Mar 28
TI  - Visible light promoted photoredox C(sp(3))-H bond functionalization of 
      tetrahydroisoquinolines in flow.
PG  - 2668-2675
LID - 10.1039/d0ob02582h [doi]
AB  - A merger of organocatalysis and visible light photoredox catalysis performed in 
      flow allowed access to a wide range of functionalized N-aryl-substituted 
      tetrahydroisoquinolines (THIQs) in a formal C-H oxidation/Mannich reaction. 
      Strecker type functionalization and copper-catalyzed alkynylation of several 
      N-aryl-substituted THIQs were also successfully performed in flow, giving 
      valuable products with high efficiencies. The use of custom-made porous polymeric 
      type microreactors proved to be crucial regarding the C-H oxidation step and 
      overall reaction performance.
FAU - Filipovic, Ana
AU  - Filipovic A
AD  - University of Belgrade-Institute of Chemistry, Technology and Metallurgy, 
      Njegoseva 12, 11000 Belgrade, Republic of Serbia. bbondzic@chem.bg.ac.rs.
FAU - DZambaski, Zdravko
AU  - DZambaski Z
FAU - Vasiljevic-Radovic, Dana
AU  - Vasiljevic-Radovic D
FAU - BondZic, Bojan P
AU  - BondZic BP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210305
PL  - England
TA  - Org Biomol Chem
JT  - Organic & biomolecular chemistry
JID - 101154995
SB  - IM
EDAT- 2021/03/06 06:00
MHDA- 2021/03/06 06:01
CRDT- 2021/03/05 12:11
PHST- 2021/03/06 06:00 [pubmed]
PHST- 2021/03/06 06:01 [medline]
PHST- 2021/03/05 12:11 [entrez]
AID - 10.1039/d0ob02582h [doi]
PST - ppublish
SO  - Org Biomol Chem. 2021 Mar 28;19(12):2668-2675. doi: 10.1039/d0ob02582h. Epub 2021 
      Mar 5.