PMID- 33667571
OWN - NLM
STAT- MEDLINE
DCOM- 20211103
LR  - 20211103
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 273
DP  - 2021 Jun 12
TI  - A comprehensive study of three species of Paeonia stem and leaf phytochemicals, 
      and their antioxidant activities.
PG  - 113985
LID - S0378-8741(21)00212-9 [pii]
LID - 10.1016/j.jep.2021.113985 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Paeonia plants have been widely used as 
      traditional Chinese medicinal materials for more than 2,000 years in the 
      treatment of cardiovascular, extravasated blood and female genital diseases; 
      paeoniflorin and paeonol have been implicated as the plants' primary active 
      ingredients. AIM OF THE STUDY: Previous studies have been singularly focused on 
      the chemical constituents and content variation of the Paeonia roots in the 
      advancement of traditional Chinese medicine, with the plants' stems and leaves 
      considered useless. This study aims to explore the chemical constituents, content 
      variation, and antioxidant capacity in Paeonia stems and leaves for the future 
      utilization of traditional Chinese medicine, given that current practices of 
      digging and trade endanger Paeonia in the wild. MATERIALS AND METHODS: Herein, 
      secondary metabolites from the stems and leaves from six developmental stages of 
      the annual growth cycle of Paeonia ostii T. Hong & J. X. Zhang, P. 'Hexie', and 
      P. lactiflora Pall. were qualitatively and quantitatively analyzed via 
      high-performance liquid chromatography with a diode array detector (HPLC-DAD) and 
      high-performance liquid chromatography quadrupole time-of-flight mass 
      spectrometry (HPLC-Q-TOF-MS). Antioxidant capacity at each stage was also 
      evaluated by various free radical scavenging assays. RESULTS: A total of 24 
      metabolites were detected and identified, including 5 monoterpene glycosides, 4 
      tannins, 5 phenols, 9 flavonoids, and paeonol. Excepting paeonol and the phenols, 
      the levels of each metabolite category were significantly higher in the leaves 
      than the stems during all developmental stages. The paeoniflorin content in the 
      P. ostii leaves was the highest during the first developmental stage and higher 
      than the standards of the Chinese Pharmacopoeia, suggesting it to be the optimal 
      harvesting stage for medicinal uses. Notably, the antioxidant capacity of the 
      leaves was significantly greater than in the stems, particularly for the leaves 
      of P. 'Hexie'. CONCLUSION: Our study indicates that the leaves of P. 'Hexie' have 
      the potential to be a worthy medicinal substitute to Paeonia roots due to their 
      high monoterpene glycosides, phenols, and flavonoids as well as their strong 
      antioxidant capacity. Further, this study provides a theoretical basis for the 
      development and utilization of non-root Paeonia plant sections as medicinal plant 
      resources.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Tong, Ning-Ning
AU  - Tong NN
AD  - Key Laboratory of Plant Resources/Beijing Botanical Garden, Institute of Botany, 
      Chinese Academy of Sciences, Beijing, 100093, China; University of Chinese 
      Academy of Sciences, Beijing, 100049, China. Electronic address: 
      tongnn@ibcas.ac.cn.
FAU - Zhou, Xiao-Yang
AU  - Zhou XY
AD  - Key Laboratory of Plant Resources/Beijing Botanical Garden, Institute of Botany, 
      Chinese Academy of Sciences, Beijing, 100093, China. Electronic address: 
      zhouxiaoyang@ibcas.ac.cn.
FAU - Peng, Li-Ping
AU  - Peng LP
AD  - Key Laboratory of Plant Resources/Beijing Botanical Garden, Institute of Botany, 
      Chinese Academy of Sciences, Beijing, 100093, China. Electronic address: 
      pengliping@ibcas.ac.cn.
FAU - Liu, Zheng-An
AU  - Liu ZA
AD  - Key Laboratory of Plant Resources/Beijing Botanical Garden, Institute of Botany, 
      Chinese Academy of Sciences, Beijing, 100093, China. Electronic address: 
      liuzhengan@ibcas.ac.cn.
FAU - Shu, Qing-Yan
AU  - Shu QY
AD  - Key Laboratory of Plant Resources/Beijing Botanical Garden, Institute of Botany, 
      Chinese Academy of Sciences, Beijing, 100093, China. Electronic address: 
      shuqy@ibcas.ac.cn.
LA  - eng
PT  - Journal Article
DEP - 20210302
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Antioxidants)
RN  - 0 (Flavonoids)
RN  - 0 (Glycosides)
RN  - 0 (Phenols)
RN  - 0 (Phytochemicals)
RN  - 0 (Tannins)
SB  - IM
MH  - Antioxidants/chemistry/*pharmacology
MH  - Flavonoids/chemistry
MH  - Glycosides/chemistry
MH  - Paeonia/*chemistry/classification
MH  - Phenols/chemistry
MH  - Phytochemicals/analysis
MH  - Phytotherapy
MH  - Plant Leaves/*chemistry
MH  - Plant Stems/*chemistry
MH  - Plants, Medicinal
MH  - Species Specificity
MH  - Tannins/chemistry
OTO - NOTNLM
OT  - Antioxidant activity
OT  - Medicinal plants
OT  - Monoterpene glycosides
OT  - Paeonia
OT  - Paeoniflorin
EDAT- 2021/03/06 06:00
MHDA- 2021/11/04 06:00
CRDT- 2021/03/05 20:11
PHST- 2020/12/23 00:00 [received]
PHST- 2021/02/25 00:00 [revised]
PHST- 2021/02/26 00:00 [accepted]
PHST- 2021/03/06 06:00 [pubmed]
PHST- 2021/11/04 06:00 [medline]
PHST- 2021/03/05 20:11 [entrez]
AID - S0378-8741(21)00212-9 [pii]
AID - 10.1016/j.jep.2021.113985 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2021 Jun 12;273:113985. doi: 10.1016/j.jep.2021.113985. Epub 
      2021 Mar 2.