PMID- 33667595
OWN - NLM
STAT- MEDLINE
DCOM- 20220223
LR  - 20230920
IS  - 1873-5118 (Electronic)
IS  - 0301-0082 (Print)
IS  - 0301-0082 (Linking)
VI  - 201
DP  - 2021 Jun
TI  - Dopamine-related striatal neurophysiology is associated with specialization of 
      frontostriatal reward circuitry through adolescence.
PG  - 101997
LID - S0301-0082(21)00011-3 [pii]
LID - 10.1016/j.pneurobio.2021.101997 [doi]
AB  - Characterizing developmental changes in frontostriatal circuitry is critical to 
      understanding adolescent development and can clarify neurobiological mechanisms 
      underlying increased reward sensitivity and risk-taking and the emergence of 
      psychopathology during this period. However, the role of striatal neurobiology in 
      the development of frontostriatal circuitry through human adolescence remains 
      largely unknown. We examined background connectivity during a reward-guided 
      decision-making task ("reward-state"), in addition to resting-state, and assessed 
      the association between age-related changes in frontostriatal connectivity and 
      age-related changes in reward learning and risk-taking through adolescence. 
      Further, we examined the contribution of dopaminergic processes to changes in 
      frontostriatal circuitry and decision-making using MR-based assessments of 
      striatal tissue-iron as a correlate of dopamine-related neurobiology. 
      Connectivity between the nucleus accumbens (NAcc) and ventral anterior cingulate, 
      subgenual cingulate, and orbitofrontal cortices decreased through adolescence 
      into adulthood, and decreases in reward-state connectivity were associated with 
      improvements reward-guided decision-making as well as with decreases in 
      risk-taking. Finally, NAcc tissue-iron mediated age-related changes and was 
      associated with variability in connectivity, and developmental increases in NAcc 
      R2' corresponded with developmental decreases in connectivity. Our results 
      provide evidence that dopamine-related striatal properties contribute to the 
      specialization of frontostriatal circuitry, potentially underlying changes in 
      risk-taking and reward sensitivity into adulthood.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Parr, Ashley C
AU  - Parr AC
AD  - Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 14213, United 
      States. Electronic address: acp73@pitt.edu.
FAU - Calabro, Finnegan
AU  - Calabro F
AD  - Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 14213, United 
      States.
FAU - Larsen, Bart
AU  - Larsen B
AD  - Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 14213, United 
      States; Department of Psychiatry, Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia, PA, 19104, United States.
FAU - Tervo-Clemmens, Brenden
AU  - Tervo-Clemmens B
AD  - Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 14213, United 
      States.
FAU - Elliot, Samuel
AU  - Elliot S
AD  - Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 14213, United 
      States.
FAU - Foran, Will
AU  - Foran W
AD  - Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 14213, United 
      States.
FAU - Olafsson, Valur
AU  - Olafsson V
AD  - NUBIC, Northeastern University, Boston, MA, 02115, United States.
FAU - Luna, Beatriz
AU  - Luna B
AD  - Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 14213, United 
      States.
LA  - eng
GR  - R01 MH080243/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20210302
PL  - England
TA  - Prog Neurobiol
JT  - Progress in neurobiology
JID - 0370121
RN  - E1UOL152H7 (Iron)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Dopamine
MH  - Humans
MH  - Iron
MH  - Magnetic Resonance Imaging
MH  - Neural Pathways
MH  - *Neurophysiology
MH  - *Reward
PMC - PMC8096717
MID - NIHMS1683045
OTO - NOTNLM
OT  - Adolescent development
OT  - Dopamine
OT  - Functional connectivity
OT  - Reward
OT  - Tissue iron
COIS- Declaration of Interests The authors declare no competing interests.
EDAT- 2021/03/06 06:00
MHDA- 2022/02/24 06:00
PMCR- 2022/06/01
CRDT- 2021/03/05 20:11
PHST- 2020/08/11 00:00 [received]
PHST- 2021/01/08 00:00 [revised]
PHST- 2021/01/11 00:00 [accepted]
PHST- 2021/03/06 06:00 [pubmed]
PHST- 2022/02/24 06:00 [medline]
PHST- 2021/03/05 20:11 [entrez]
PHST- 2022/06/01 00:00 [pmc-release]
AID - S0301-0082(21)00011-3 [pii]
AID - 10.1016/j.pneurobio.2021.101997 [doi]
PST - ppublish
SO  - Prog Neurobiol. 2021 Jun;201:101997. doi: 10.1016/j.pneurobio.2021.101997. Epub 
      2021 Mar 2.