PMID- 33667637
OWN - NLM
STAT- MEDLINE
DCOM- 20210624
LR  - 20210624
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 226
DP  - 2021 May
TI  - The HLA-DR4-DQ8 phenotype of the recipient is associated with increased mortality 
      after kidney transplantation.
PG  - 108711
LID - S1521-6616(21)00048-6 [pii]
LID - 10.1016/j.clim.2021.108711 [doi]
AB  - The importance of the human leukocyte antigen (HLA) system in kidney 
      transplantation is well-known, but it remains unexplored if patient HLA antigens 
      constitute independent risk factors in complications after transplantation. We 
      hypothesized that specific HLA class II phenotypes associated with 
      immune-mediated disease (HLA-IMD) predispose to immunological activity and/or 
      complications after kidney transplantation. Based on the literature we defined 
      HLA-DR2-DQ6; -DR3-DQ2 and -DR4-DQ8 as HLA-IMD phenotypes. We investigated 
      associations between HLA-IMD phenotypes in patients, biomarkers of systemic 
      chronic inflammation at the time of transplantation, and the outcome after kidney 
      transplantation in a retrospective cohort study of 611 kidney transplanted 
      patients. The HLA-IMD phenotypes were associated with higher levels of biomarkers 
      of systemic inflammation. The HLA-DR4-DQ8 phenotype was associated with mortality 
      after transplantation in Cox analyses with adjustments for confounders. Data 
      support the hypothesis that specific HLA class II phenotypes affects 
      immunological pathways that determine the midterm clinical outcome of kidney 
      transplantation.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Lund, Kit P
AU  - Lund KP
AD  - Department of Clinical Immunology 7631, Rigshospitalet, University Hospital of 
      Copenhagen, Ole Maaloes Vej 26, DK-2200 Copenhagen, Denmark. Electronic address: 
      kit.lund@regionh.dk.
FAU - Eriksson, Frank
AU  - Eriksson F
AD  - Section of Biostatistics, Department of Public Health, University of Copenhagen, 
      Oster Farimagsgade 5, DK-1014 Copenhagen, Denmark.
FAU - Hauge, Anne W
AU  - Hauge AW
AD  - Department of Clinical Immunology 7631, Rigshospitalet, University Hospital of 
      Copenhagen, Ole Maaloes Vej 26, DK-2200 Copenhagen, Denmark.
FAU - Mora-Jensen, Helena I
AU  - Mora-Jensen HI
AD  - Department of Clinical Immunology 7631, Rigshospitalet, University Hospital of 
      Copenhagen, Ole Maaloes Vej 26, DK-2200 Copenhagen, Denmark.
FAU - Sorensen, Soren S
AU  - Sorensen SS
AD  - Department of Nephrology P, Rigshospitalet, University Hospital of Copenhagen, 
      Blegdamsvej 9, DK-2100 Copenhagen, Denmark; Department of Clinical Medicine, 
      University of Copenhagen, Blegdamsvej 3B, DK-2100 Copenhagen, Denmark.
FAU - Bruunsgaard, Helle
AU  - Bruunsgaard H
AD  - Department of Clinical Immunology 7631, Rigshospitalet, University Hospital of 
      Copenhagen, Ole Maaloes Vej 26, DK-2200 Copenhagen, Denmark; Department of 
      Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, DK-2100 Copenhagen, 
      Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210302
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DR4 Antigen)
SB  - IM
MH  - Adult
MH  - Biomarkers/metabolism
MH  - Female
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - HLA-DR4 Antigen/*genetics
MH  - Humans
MH  - Inflammation/genetics/mortality
MH  - Kidney Transplantation/*mortality
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Retrospective Studies
OTO - NOTNLM
OT  - HLA
OT  - Inflammation
OT  - Kidney transplantation
OT  - Mortality
EDAT- 2021/03/06 06:00
MHDA- 2021/06/25 06:00
CRDT- 2021/03/05 20:11
PHST- 2020/09/23 00:00 [received]
PHST- 2021/02/27 00:00 [revised]
PHST- 2021/02/28 00:00 [accepted]
PHST- 2021/03/06 06:00 [pubmed]
PHST- 2021/06/25 06:00 [medline]
PHST- 2021/03/05 20:11 [entrez]
AID - S1521-6616(21)00048-6 [pii]
AID - 10.1016/j.clim.2021.108711 [doi]
PST - ppublish
SO  - Clin Immunol. 2021 May;226:108711. doi: 10.1016/j.clim.2021.108711. Epub 2021 Mar 
      2.