PMID- 33668502
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210316
IS  - 2076-0817 (Print)
IS  - 2076-0817 (Electronic)
IS  - 2076-0817 (Linking)
VI  - 10
IP  - 2
DP  - 2021 Feb 13
TI  - Antiviral Mechanism of Tea Polyphenols against Porcine Reproductive and 
      Respiratory Syndrome Virus.
LID - 10.3390/pathogens10020202 [doi]
LID - 202
AB  - Neither inactivated nor attenuated vaccines can effectively prevent and control 
      the infection and spread of porcine reproductive and respiratory syndrome virus 
      (PRRSV). Therefore, it is necessary to broaden new horizons and to conceive 
      effective preventive strategies. The main components of Tea polyphenol (TPP) are 
      catechins and their derivatives. TPP has many physiological activities and has 
      certain antiviral and antifungal effects. However, whether TPP shows anti-PRRSV 
      activity remains unclear. We found that TPP effectively inhibited PRRSV infection 
      in Marc-145 cells by suppressing the stages of viral attachment, internalization, 
      replication, and release. TPP exhibited a potent anti-PRRSV effect regardless of 
      pre-treatment or post-treatment. In addition, we demonstrated that TPP restrained 
      PRRSV-induced p65 entry into the nucleus to suppress the activation of the NF-kappaB 
      signaling pathway, which ultimately leads to the inhibition of the expression of 
      inflammatory cytokines. Furthermore, TPP limited the synthesis of viral 
      non-structural protein 2 (nsp2), the core component of viral replication 
      transcription complexes, which may contribute to the inhibition of viral RNA 
      replication. TPP has the potential to develop into an effective antiviral agent 
      for PRRSV prevention and control in the future.
FAU - Wang, Xun
AU  - Wang X
AD  - State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen 
      University, North Third Road, Guangzhou Higher Education Mega Center, Guangzhou 
      510006, Guangdong, China.
FAU - Dong, Wenjuan
AU  - Dong W
AD  - State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen 
      University, North Third Road, Guangzhou Higher Education Mega Center, Guangzhou 
      510006, Guangdong, China.
FAU - Zhang, Xiaoxiao
AU  - Zhang X
AD  - State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen 
      University, North Third Road, Guangzhou Higher Education Mega Center, Guangzhou 
      510006, Guangdong, China.
FAU - Zhu, Zhenbang
AU  - Zhu Z
AD  - State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen 
      University, North Third Road, Guangzhou Higher Education Mega Center, Guangzhou 
      510006, Guangdong, China.
FAU - Chen, Yaosheng
AU  - Chen Y
AD  - State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen 
      University, North Third Road, Guangzhou Higher Education Mega Center, Guangzhou 
      510006, Guangdong, China.
FAU - Liu, Xiaohong
AU  - Liu X
AD  - State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen 
      University, North Third Road, Guangzhou Higher Education Mega Center, Guangzhou 
      510006, Guangdong, China.
FAU - Guo, Chunhe
AU  - Guo C
AUID- ORCID: 0000-0002-7859-1985
AD  - State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen 
      University, North Third Road, Guangzhou Higher Education Mega Center, Guangzhou 
      510006, Guangdong, China.
LA  - eng
GR  - 31601917/National Natural Science Foundation of China/
GR  - 201804020039/Science and Technology Planning Project for Guangzhou/
PT  - Journal Article
DEP - 20210213
PL  - Switzerland
TA  - Pathogens
JT  - Pathogens (Basel, Switzerland)
JID - 101596317
PMC - PMC7917843
OTO - NOTNLM
OT  - PRRSV
OT  - antiviral
OT  - cytokine
OT  - tea polyphenol
COIS- The authors declare that they have no competing interests.
EDAT- 2021/03/07 06:00
MHDA- 2021/03/07 06:01
PMCR- 2021/02/13
CRDT- 2021/03/06 01:02
PHST- 2021/01/13 00:00 [received]
PHST- 2021/02/07 00:00 [revised]
PHST- 2021/02/10 00:00 [accepted]
PHST- 2021/03/06 01:02 [entrez]
PHST- 2021/03/07 06:00 [pubmed]
PHST- 2021/03/07 06:01 [medline]
PHST- 2021/02/13 00:00 [pmc-release]
AID - pathogens10020202 [pii]
AID - pathogens-10-00202 [pii]
AID - 10.3390/pathogens10020202 [doi]
PST - epublish
SO  - Pathogens. 2021 Feb 13;10(2):202. doi: 10.3390/pathogens10020202.