PMID- 33668849
OWN - NLM
STAT- MEDLINE
DCOM- 20210602
LR  - 20231111
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 3
DP  - 2021 Feb 25
TI  - Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn 
      Anthropometry in India: Findings from DHANI.
LID - 10.3390/nu13030730 [doi]
LID - 730
AB  - Long-chain omega-3 fatty acid status during pregnancy may influence newborn 
      anthropometry and duration of gestation. Evidence from high-quality trials from 
      low- and middle-income countries (LMICs) is limited. We conducted a double-blind, 
      randomized, placebo-controlled trial among 957 pregnant women (singleton 
      gestation, 14-20 weeks' gestation at enrollment) in India to test the 
      effectiveness of 400 mg/day algal docosahexaenoic acid (DHA) compared to placebo 
      provided from enrollment through delivery. Among 3379 women who were screened, 
      1171 were found eligible; 957 were enrolled and were randomized. The intervention 
      was two microencapsulated algal DHA (200 x 2 = 400 mg/day) or two 
      microencapsulated soy and corn oil placebo tablets to be consumed daily from 
      enrollment (</=20 weeks) through delivery. The primary outcome was newborn 
      anthropometry (birth weight, length, head circumference). Secondary outcomes were 
      gestational age and 1 and 5 min Appearance, Pulse, Grimace, Activity, and 
      Respiration (APGAR) score. The groups (DHA; n = 478 and placebo; n = 479) were 
      well balanced at baseline. There were 902 live births. Compliance with the 
      intervention was similar across groups (DHA: 88.5%; placebo: 87.1%). There were 
      no significant differences between DHA and placebo groups for birth weight 
      (2750.6 +/- 421.5 vs. 2768.2 +/- 436.6 g, p = 0.54), length (47.3 +/- 2.0 vs. 47.5 +/- 
      2.0 cm, p = 0.13), or head circumference (33.7 +/- 1.4 vs. 33.8 +/- 1.4 cm, p = 
      0.15). The mean gestational age at delivery was similar between groups (DHA: 38.8 
      +/- 1.7 placebo: 38.8 +/- 1.7 wk, p = 0.54) as were APGAR scores at 1 and 5 min. 
      Supplementing mothers through pregnancy with 400 mg/day DHA did not impact the 
      offspring's birthweight, length, or head circumference.
FAU - Khandelwal, Shweta
AU  - Khandelwal S
AUID- ORCID: 0000-0002-7208-670X
AD  - Public Health Foundation of India, Gurugram 122003, India.
AD  - Centre for Chronic Disease Control, New Delhi 110016, India.
FAU - Kondal, Dimple
AU  - Kondal D
AD  - Public Health Foundation of India, Gurugram 122003, India.
AD  - Centre for Chronic Disease Control, New Delhi 110016, India.
FAU - Chaudhry, Monica
AU  - Chaudhry M
AD  - Public Health Foundation of India, Gurugram 122003, India.
FAU - Patil, Kamal
AU  - Patil K
AD  - Department of Obstetrics and Gynaecology, KAHER's J. N. Medical College, Belagavi 
      590010, India.
FAU - Swamy, Mallaiah Kenchaveeraiah
AU  - Swamy MK
AD  - Department of Obstetrics and Gynaecology, KAHER's J. N. Medical College, Belagavi 
      590010, India.
FAU - Pujeri, Gangubai
AU  - Pujeri G
AD  - Department of Obstetrics and Gynaecology, KAHER's J. N. Medical College, Belagavi 
      590010, India.
FAU - Mane, Swati Babu
AU  - Mane SB
AD  - Department of Obstetrics and Gynaecology, KAHER's J. N. Medical College, Belagavi 
      590010, India.
FAU - Kudachi, Yashaswi
AU  - Kudachi Y
AD  - Department of Obstetrics and Gynaecology, KAHER's J. N. Medical College, Belagavi 
      590010, India.
FAU - Gupta, Ruby
AU  - Gupta R
AD  - Public Health Foundation of India, Gurugram 122003, India.
AD  - Centre for Chronic Disease Control, New Delhi 110016, India.
FAU - Ramakrishnan, Usha
AU  - Ramakrishnan U
AD  - Hubert Department of Global Health, Rollins School of Public Health, Emory 
      University, Atlanta, GA 30322, USA.
FAU - Stein, Aryeh D
AU  - Stein AD
AUID- ORCID: 0000-0003-1138-6458
AD  - Hubert Department of Global Health, Rollins School of Public Health, Emory 
      University, Atlanta, GA 30322, USA.
FAU - Prabhakaran, Dorairaj
AU  - Prabhakaran D
AD  - Public Health Foundation of India, Gurugram 122003, India.
AD  - Centre for Chronic Disease Control, New Delhi 110016, India.
FAU - Tandon, Nikhil
AU  - Tandon N
AD  - All India Institute of Medical Sciences, New Delhi 110016, India.
LA  - eng
GR  - IA/CPHE/14/1/501498/The Wellcome Trust DBT India Alliance/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20210225
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 25167-62-8 (Docosahexaenoic Acids)
SB  - IM
MH  - Adult
MH  - *Anthropometry
MH  - Birth Weight
MH  - *Child Development
MH  - *Dietary Supplements
MH  - Docosahexaenoic Acids/administration & dosage/*pharmacology
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - India
MH  - Infant, Newborn
MH  - Pregnancy
MH  - *Prenatal Nutritional Physiological Phenomena
MH  - Young Adult
PMC - PMC7996222
OTO - NOTNLM
OT  - anthropometry
OT  - birth length
OT  - birth weight
OT  - docosahexaenoic acid (DHA)
OT  - head circumference
OT  - long chain omega-3 fatty acids
OT  - maternal supplementation
OT  - pregnancy outcomes
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2021/03/07 06:00
MHDA- 2021/06/03 06:00
PMCR- 2021/02/25
CRDT- 2021/03/06 01:03
PHST- 2021/01/10 00:00 [received]
PHST- 2021/02/16 00:00 [revised]
PHST- 2021/02/17 00:00 [accepted]
PHST- 2021/03/06 01:03 [entrez]
PHST- 2021/03/07 06:00 [pubmed]
PHST- 2021/06/03 06:00 [medline]
PHST- 2021/02/25 00:00 [pmc-release]
AID - nu13030730 [pii]
AID - nutrients-13-00730 [pii]
AID - 10.3390/nu13030730 [doi]
PST - epublish
SO  - Nutrients. 2021 Feb 25;13(3):730. doi: 10.3390/nu13030730.