PMID- 33669682
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210316
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 11
IP  - 2
DP  - 2021 Feb 19
TI  - Self-Positivity or Self-Negativity as a Function of the Medial Prefrontal Cortex.
LID - 10.3390/brainsci11020264 [doi]
LID - 264
AB  - Self and emotions are key motivational factors of a person strivings for health 
      and well-being. Understanding neural mechanisms supporting the relationship 
      between these factors bear far-reaching implications for mental health disorders. 
      Recent work indicates a substantial overlap between self-relevant and emotion 
      information processing and has proposed the medial prefrontal cortex (MPFC) as 
      one shared neural signature. However, the precise cognitive and neural mechanisms 
      represented by the MPFC in investigations of self- and emotion-related processing 
      are largely unknown. Here we examined whether the neural underpinnings of 
      self-related processing in the MPFC link to positive or negative emotions. We 
      collected fMRI data to test the distinct and shared neural circuits of self- and 
      emotion-related processing while participants performed personal (self, friend, 
      or stranger) and emotion (happy, sad, or neutral) associative matching tasks. By 
      exploiting tight control over the factors that determine the effects of 
      self-relevance and emotions (positive: Happy vs. neutral; negative: Sad vs. 
      neutral), our univariate analysis revealed that the ventral part of the MPFC 
      (vmPFC), which has established involvement in self-prioritisation effects, was 
      not recruited in the negative emotion prioritisation effect. In contrast, there 
      were no differences in brain activity between the effects of positive emotion- 
      and self-prioritisation. These results were replicated by both region of interest 
      (ROI)-based analysis in the vmPFC and the seed- to voxel functional connectivity 
      analysis between the MPFC and the rest of the brain. The results suggest that the 
      prioritisation effects for self and positive emotions are tightly linked 
      together, and the MPFC plays a large role in discriminating between positive and 
      negative emotions in relation to self-relevance.
FAU - Yankouskaya, Alla
AU  - Yankouskaya A
AUID- ORCID: 0000-0003-0794-0989
AD  - Department of Psychology, Bournemouth University, Poole BH12 5BB, UK.
FAU - Sui, Jie
AU  - Sui J
AUID- ORCID: 0000-0002-4031-4456
AD  - The School of Psychology, University of Aberdeen, Aberdeen AB24 3FX, UK.
LA  - eng
GR  - ES/K013424/1/Economic and Social Research Council/
GR  - RPG-2019-010/Leverhulme Trust/
PT  - Journal Article
DEP - 20210219
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC7922957
OTO - NOTNLM
OT  - emotion prioritisation
OT  - fMRI
OT  - medial prefrontal cortex
OT  - self-positivity bias
OT  - self-prioritisation
COIS- The authors declare no conflict of interest.
EDAT- 2021/03/07 06:00
MHDA- 2021/03/07 06:01
PMCR- 2021/02/19
CRDT- 2021/03/06 01:05
PHST- 2021/01/14 00:00 [received]
PHST- 2021/02/15 00:00 [revised]
PHST- 2021/02/16 00:00 [accepted]
PHST- 2021/03/06 01:05 [entrez]
PHST- 2021/03/07 06:00 [pubmed]
PHST- 2021/03/07 06:01 [medline]
PHST- 2021/02/19 00:00 [pmc-release]
AID - brainsci11020264 [pii]
AID - brainsci-11-00264 [pii]
AID - 10.3390/brainsci11020264 [doi]
PST - epublish
SO  - Brain Sci. 2021 Feb 19;11(2):264. doi: 10.3390/brainsci11020264.