PMID- 33670840
OWN - NLM
STAT- MEDLINE
DCOM- 20210423
LR  - 20210423
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 18
IP  - 5
DP  - 2021 Feb 28
TI  - Combined Effects of Oligopeptides Isolated from Panax ginseng C.A. Meyer and 
      Ostrea gigas Thunberg on Sexual Function in Male Mice.
LID - 10.3390/ijerph18052349 [doi]
LID - 2349
AB  - Male sexual debility affects patients' confidence and damages the relationship 
      between the couples and thus affects the stability of the family. This study 
      aimed to investigate the effects of oligopeptides isolated from ginseng and 
      oyster (GOPs and OOPs), separately and in combination, on sexual function in male 
      mice. In the first experiment, male mice were randomly divided into five groups: 
      vehicle control group; whey protein (125.0 mg kg(-1)) group; and GOPs 62.5, 
      125.0, and 250.0 mg kg(-1) groups. In the second experiment, male mice were 
      randomly divided into five groups: vehicle control group, whey protein (160.0 mg 
      kg(-1)) group, and OOPs 80.0, 160.0, and 320.0 mg kg(-1) groups. In the third 
      experiment, male mice were randomly divided into six groups: vehicle control 
      group, whey protein (222.5 mg kg(-1)) group, and GOPs + OOPs 62.5 + 160.0, 62.5 + 
      320.0, and 125.0 + 160.0, 125.0 + 320.0 mg kg(-1) groups. Test substances were 
      given by gavage once a day for 30 days. The sexual behavior parameters, serum 
      nitric oxide (NO), testosterone, cyclic guanosine monophosphate (cGMP), and 
      phosphodiesterase-5 (PDE5) concentrations were detected. We found that GOPs at 
      250.0 mg kg(-1) improved male sexual behavior, NO, and testosterone content, 
      whereas GOPs at 62.5 and 125.0 mg kg(-1) and OOPs at 80.0, 160, and 320 mg kg(-1) 
      did not have significant effects. The combination of 62.5 mg kg(-1) GOPs + 160.0 
      mg kg(-1) OOPs and the combination of 125.0 mg kg(-1) GOPs + 320.0 mg kg(-1) OOPs 
      improved male sexual behavior, serum NO, testosterone, and cGMP contents and 
      decreased PDE5 content. The combination of 62.5 mg kg(-1) GOPs and 160.0 mg 
      kg(-1) OOPs had the best effects among four combined groups. These results 
      suggested that GOPs in combination with OOPs had the synergistic effects of 
      enhancing male sexual function, probably via elevating serum testosterone, NO, 
      and corpus cavernosum cGMP level and decreasing the corpus cavernosum PDE5 level. 
      GOPs and OOPs could be novel natural agents for improving male sexual function.
FAU - Li, Di
AU  - Li D
AD  - Department of Clinical Nutrition, Peking University People's Hospital, Beijing 
      100044, China.
FAU - Ren, Jinwei
AU  - Ren J
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China.
FAU - He, Lixia
AU  - He L
AUID- ORCID: 0000-0001-9725-8398
AD  - Division of Molecular and Cellular Oncology, Harvard Medical School, Boston, MA 
      02215, USA.
FAU - Sun, Jingqin
AU  - Sun J
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China.
FAU - Liu, Peng
AU  - Liu P
AD  - Department of Clinical Nutrition, Peking University People's Hospital, Beijing 
      100044, China.
FAU - Li, Yong
AU  - Li Y
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210228
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Oligopeptides)
RN  - 0 (Plant Extracts)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Male
MH  - Mice
MH  - Nitric Oxide
MH  - Oligopeptides
MH  - *Ostrea
MH  - *Panax
MH  - Plant Extracts
PMC - PMC7967744
OTO - NOTNLM
OT  - ginseng
OT  - male
OT  - oligopeptide
OT  - oyster
OT  - sexual
COIS- The authors declare no conflict of interest.
EDAT- 2021/03/07 06:00
MHDA- 2021/04/24 06:00
PMCR- 2021/02/28
CRDT- 2021/03/06 01:08
PHST- 2021/02/08 00:00 [received]
PHST- 2021/02/20 00:00 [revised]
PHST- 2021/02/24 00:00 [accepted]
PHST- 2021/03/06 01:08 [entrez]
PHST- 2021/03/07 06:00 [pubmed]
PHST- 2021/04/24 06:00 [medline]
PHST- 2021/02/28 00:00 [pmc-release]
AID - ijerph18052349 [pii]
AID - ijerph-18-02349 [pii]
AID - 10.3390/ijerph18052349 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2021 Feb 28;18(5):2349. doi: 
      10.3390/ijerph18052349.