PMID- 33671620
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210316
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Electronic)
IS  - 2076-2615 (Linking)
VI  - 11
IP  - 2
DP  - 2021 Feb 22
TI  - Effects of Decabrominated Diphenyl Ether Exposure on Growth, Meat Characteristics 
      and Blood Profiles in Broilers.
LID - 10.3390/ani11020565 [doi]
LID - 565
AB  - Decabrominated diphenyl ether (BDE-209) is widely used as a flame retardant and 
      is detected at high levels in the environment. Its toxicities have been reported 
      and have attracted attention. In the present study, broilers were used to 
      determine the response in growth performance, carcass traits, meat quality, blood 
      profiles and antioxidant system to BDE-209 exposure at doses of 0, 0.02, 0.4 and 
      4 mg/kg. The results showed that BDE-209 exposure at levels of 0.02 or 0.4 mg/kg 
      increased feed intake and decreased feed efficiency. BDE-209 altered the blood 
      profiles, such as reducing the numbers of white blood cells, lymphocytes and 
      neutrophilic granulocytes. As compared with the control, BDE-209 exposure 
      significantly increased abdominal fat percentages of broilers at 64.9-159.5% and 
      adversely affected the selected biochemical indicators, including alkaline 
      phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase 
      (ALT), creatine (CRE), which indicated its toxicity to liver and kidney 
      functions. Moreover, BDE-209 exposure significantly increased plasma 
      malondialdehyde (MDA) concentrations and decreased the activities of glutathione 
      peroxidase (GSH-px) and superoxide dismutase (SOD), which implied aggravating 
      oxidant stress and decline of antioxidant capacity in broilers. In conclusion, 
      our data demonstrated that the environmental pollutant BDE-209 adversely 
      influenced growth performance, increased the deposition of abdominal fat, 
      impaired antioxidant capacity and the immune system and had potential toxicity to 
      the liver and kidney of broilers.
FAU - Liu, Zehui
AU  - Liu Z
AD  - Institute for Agro-Food Standards and Testing Technology, Shanghai Academy of 
      Agricultural Sciences, Shanghai 201403, China.
FAU - Lei, Hulong
AU  - Lei H
AD  - Institute of Animal Husbandry and Veterinary Sciences, Shanghai Academy of 
      Agricultural Sciences, Shanghai 201106, China.
FAU - Tang, Renyong
AU  - Tang R
AD  - School of Pharmacy and Biological Engineering, Chengdu University, Chengdu 
      610106, China.
FAU - Yang, Junhua
AU  - Yang J
AD  - Institute for Agro-Food Standards and Testing Technology, Shanghai Academy of 
      Agricultural Sciences, Shanghai 201403, China.
FAU - Guo, Xiulan
AU  - Guo X
AD  - School of Pharmacy and Biological Engineering, Chengdu University, Chengdu 
      610106, China.
FAU - Huang, Renmao
AU  - Huang R
AD  - Institute for Agro-Food Standards and Testing Technology, Shanghai Academy of 
      Agricultural Sciences, Shanghai 201403, China.
AD  - School of Pharmacy and Biological Engineering, Chengdu University, Chengdu 
      610106, China.
FAU - Rao, Qinxiong
AU  - Rao Q
AD  - Institute for Agro-Food Standards and Testing Technology, Shanghai Academy of 
      Agricultural Sciences, Shanghai 201403, China.
FAU - Cheng, Lin
AU  - Cheng L
AD  - Institute for Agro-Food Standards and Testing Technology, Shanghai Academy of 
      Agricultural Sciences, Shanghai 201403, China.
FAU - Zhao, Zhihui
AU  - Zhao Z
AD  - Institute for Agro-Food Standards and Testing Technology, Shanghai Academy of 
      Agricultural Sciences, Shanghai 201403, China.
LA  - eng
GR  - National Key Research and Development Program of China (2017YFC1600302)/Ministry 
      of Science and Technology of China/
PT  - Journal Article
DEP - 20210222
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC7926798
OTO - NOTNLM
OT  - antioxidant capacity
OT  - broilers
OT  - decabrominated diphenyl ether
OT  - meat characteristics
OT  - toxicity assessment
COIS- The authors declare no conflict of interest.
EDAT- 2021/03/07 06:00
MHDA- 2021/03/07 06:01
PMCR- 2021/02/22
CRDT- 2021/03/06 01:11
PHST- 2021/01/12 00:00 [received]
PHST- 2021/02/17 00:00 [revised]
PHST- 2021/02/18 00:00 [accepted]
PHST- 2021/03/06 01:11 [entrez]
PHST- 2021/03/07 06:00 [pubmed]
PHST- 2021/03/07 06:01 [medline]
PHST- 2021/02/22 00:00 [pmc-release]
AID - ani11020565 [pii]
AID - animals-11-00565 [pii]
AID - 10.3390/ani11020565 [doi]
PST - epublish
SO  - Animals (Basel). 2021 Feb 22;11(2):565. doi: 10.3390/ani11020565.