PMID- 33672150
OWN - NLM
STAT- MEDLINE
DCOM- 20210826
LR  - 20210826
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 10
IP  - 2
DP  - 2021 Feb 23
TI  - Establishment of Human Leukocyte Antigen-Mismatched Immune Responses after 
      Transplantation of Human Liver Bud in Humanized Mouse Models.
LID - 10.3390/cells10020476 [doi]
LID - 476
AB  - Humanized mouse models have contributed significantly to human immunology 
      research. In transplant immunity, human immune cell responses to donor grafts 
      have not been reproduced in a humanized animal model. To elicit human T-cell 
      immune responses, we generated immune-compromised nonobese diabetic/Shi-scid, 
      IL-2RgammaKO Jic (NOG) with a homozygous expression of human leukocyte antigen (HLA) 
      class I heavy chain (NOG-HLA-A2Tg) mice. After the transplantation of HLA-A2 
      human hematopoietic stem cells into NOG-HLA-A2Tg, we succeeded in achieving 
      alloimmune responses after the HLA-mismatched human-induced pluripotent stem cell 
      (hiPSC)-derived liver-like tissue transplantation. This immune response was 
      inhibited by administering tacrolimus. In this model, we reproduced allograft 
      rejection after the human iPSC-derived liver-like tissue transplantation. Human 
      tissue transplantation on the humanized mouse liver surface is a good model that 
      can predict T-cell-mediated cellular rejection that may occur when organ 
      transplantation is performed.
FAU - Mori, Akihiro
AU  - Mori A
AD  - Department of Regenerative Medicine, Yokohama City University Graduate School of 
      Medicine, 3-9, Fuku-ura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
FAU - Murata, Soichiro
AU  - Murata S
AUID- ORCID: 0000-0001-7367-301X
AD  - Department of Regenerative Medicine, Yokohama City University Graduate School of 
      Medicine, 3-9, Fuku-ura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
AD  - Division of Regenerative Medicine, University of Tokyo, 4-6-1, Shirokanedai, 
      Minato-ku, Tokyo 108-8639, Japan.
FAU - Tashiro, Nao
AU  - Tashiro N
AD  - Department of Regenerative Medicine, Yokohama City University Graduate School of 
      Medicine, 3-9, Fuku-ura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
FAU - Tadokoro, Tomomi
AU  - Tadokoro T
AD  - Department of Regenerative Medicine, Yokohama City University Graduate School of 
      Medicine, 3-9, Fuku-ura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
FAU - Okamoto, Satoshi
AU  - Okamoto S
AD  - Department of Regenerative Medicine, Yokohama City University Graduate School of 
      Medicine, 3-9, Fuku-ura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
FAU - Otsuka, Ryo
AU  - Otsuka R
AD  - Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Sapporo, 
      Hokkaido 060-0815, Japan.
FAU - Wada, Haruka
AU  - Wada H
AD  - Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Sapporo, 
      Hokkaido 060-0815, Japan.
FAU - Murata, Tomoki
AU  - Murata T
AD  - Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Sapporo, 
      Hokkaido 060-0815, Japan.
FAU - Takahashi, Takeshi
AU  - Takahashi T
AD  - Central Institute for Experimental Animals (CIEA), Kawasaki 210-0821, Japan.
FAU - Seino, Ken-Ichiro
AU  - Seino KI
AD  - Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Sapporo, 
      Hokkaido 060-0815, Japan.
FAU - Taniguchi, Hideki
AU  - Taniguchi H
AD  - Department of Regenerative Medicine, Yokohama City University Graduate School of 
      Medicine, 3-9, Fuku-ura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
AD  - Division of Regenerative Medicine, University of Tokyo, 4-6-1, Shirokanedai, 
      Minato-ku, Tokyo 108-8639, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210223
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - 0 (HLA Antigens)
RN  - WM0HAQ4WNM (Tacrolimus)
SB  - IM
MH  - Allografts/immunology
MH  - Animals
MH  - Disease Models, Animal
MH  - Graft Rejection/immunology
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - *Immunity
MH  - Induced Pluripotent Stem Cells/metabolism
MH  - Liver/*immunology
MH  - *Liver Transplantation
MH  - Lymphocytes/metabolism
MH  - Mice, Transgenic
MH  - Tacrolimus/administration & dosage/pharmacology
PMC - PMC7927063
OTO - NOTNLM
OT  - allograft rejection
OT  - human iPS cell
OT  - humanized mouse
OT  - liver bud
COIS- The authors declare no conflict of interest.
EDAT- 2021/03/07 06:00
MHDA- 2021/08/27 06:00
PMCR- 2021/02/23
CRDT- 2021/03/06 01:12
PHST- 2021/01/09 00:00 [received]
PHST- 2021/02/05 00:00 [revised]
PHST- 2021/02/18 00:00 [accepted]
PHST- 2021/03/06 01:12 [entrez]
PHST- 2021/03/07 06:00 [pubmed]
PHST- 2021/08/27 06:00 [medline]
PHST- 2021/02/23 00:00 [pmc-release]
AID - cells10020476 [pii]
AID - cells-10-00476 [pii]
AID - 10.3390/cells10020476 [doi]
PST - epublish
SO  - Cells. 2021 Feb 23;10(2):476. doi: 10.3390/cells10020476.