PMID- 33672569
OWN - NLM
STAT- MEDLINE
DCOM- 20210423
LR  - 20210423
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 18
IP  - 4
DP  - 2021 Feb 20
TI  - The Use of Middle Latency Auditory Evoked Potentials (MLAEP) as Methodology for 
      Evaluating Sedation Level in Propofol-Drug Induced Sleep Endoscopy (DISE) 
      Procedure.
LID - 10.3390/ijerph18042070 [doi]
LID - 2070
AB  - To analyze the middle latency auditory evoked potential index (MLAEPi), compared 
      to the standard bispectral index (BIS), as a method for evaluating the sedation 
      level in drug-induced sleep endoscopy (DISE). In this controlled clinical study 
      on a sample of 99 obstructive sleep apnea (OSA) or snoring patients, we compared 
      the MLAEPi with the BIS after propofol infusion during the standard DISE 
      technique in order to define the MLAEPi values within the observational window of 
      the procedure. The DISE procedure was divided into eight steps, and we collected 
      both MLAEPi and BIS data values from the same patient in every step. The MLAEPi 
      showed a faster response than the BIS after propofol infusion during DISE. 
      Therefore, the clinical use of the MLAEPi in evaluating the sedation level seems 
      to be a good alternative to the current technological standards.
FAU - Arigliani, Michele
AU  - Arigliani M
AD  - ENT Unit, "V.Fazzi" Hospital, 73100 ASL Lecce, Italy.
FAU - Toraldo, Domenico M
AU  - Toraldo DM
AD  - Department of Rehabilitation, Cardiorespiratory Rehabilitation Unit, "V.Fazzi" 
      Hospital, 73100 ASL Lecce, Italy.
FAU - Ciavolino, Enrico
AU  - Ciavolino E
AD  - Department of History, Society and Human Studies, University of Salento, 73100 
      Lecce, Italy.
AD  - Wyzsza Szkola Bankowa w Gdansku, aleja Grunwaldzka 238A, 80-266 Gdansk, Poland.
FAU - Lattante, Caterina
AU  - Lattante C
AD  - Anesthesia and Intensive Care Department, "V.Fazzi" Hospital, 73100 ASL Lecce, 
      Italy.
FAU - Conte, Luana
AU  - Conte L
AUID- ORCID: 0000-0002-8741-3478
AD  - Laboratory of Interdisciplinary Research Applied to Medicine (DReAM), University 
      of Salento and ASL (Local Health Authority) at the "V Fazzi" Hospital, 73100 
      Lecce, Italy.
AD  - Laboratory of Advanced Data Analysis for Medicine (ADAM), Department of 
      Mathematics and Physics "E. De Giorgi", University of Salento, 73100 Lecce, 
      Italy.
FAU - Arima, Serena
AU  - Arima S
AD  - Department of History, Society and Human Studies, University of Salento, 73100 
      Lecce, Italy.
FAU - Arigliani, Caterina
AU  - Arigliani C
AD  - General Medicine Department, Univerzita Pavla Jozefa Safarika, 04001 Kosiciach, 
      Slovakia.
FAU - Palumbo, Antonio
AU  - Palumbo A
AD  - ENT Unit, "V.Fazzi" Hospital, 73100 ASL Lecce, Italy.
FAU - De Benedetto, Michele
AU  - De Benedetto M
AD  - ENT Unit, "V.Fazzi" Hospital, 73100 ASL Lecce, Italy.
LA  - eng
PT  - Journal Article
DEP - 20210220
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Pharmaceutical Preparations)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Endoscopy
MH  - Evoked Potentials, Auditory
MH  - Humans
MH  - *Pharmaceutical Preparations
MH  - *Propofol
MH  - Sleep
PMC - PMC7924024
OTO - NOTNLM
OT  - MLAEP index
OT  - auditory evoked potentials
OT  - bispectral index
OT  - central sleep apnea
OT  - drug-induced sleep endoscopy
OT  - middle latency auditory evoked potentials
OT  - obstructive sleep apnea
OT  - positive airway pressure
OT  - propofol
COIS- The authors declare no conflict of interest. All authors certify that they have 
      no affiliations with or involvement in any organization or entity with any 
      financial interest or non-financial interest in the subject matter or materials 
      discussed in this manuscript.
EDAT- 2021/03/07 06:00
MHDA- 2021/04/24 06:00
PMCR- 2021/02/01
CRDT- 2021/03/06 01:13
PHST- 2020/12/15 00:00 [received]
PHST- 2021/02/04 00:00 [revised]
PHST- 2021/02/12 00:00 [accepted]
PHST- 2021/03/06 01:13 [entrez]
PHST- 2021/03/07 06:00 [pubmed]
PHST- 2021/04/24 06:00 [medline]
PHST- 2021/02/01 00:00 [pmc-release]
AID - ijerph18042070 [pii]
AID - ijerph-18-02070 [pii]
AID - 10.3390/ijerph18042070 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2021 Feb 20;18(4):2070. doi: 
      10.3390/ijerph18042070.