PMID- 33672973
OWN - NLM
STAT- MEDLINE
DCOM- 20210726
LR  - 20210726
IS  - 2073-4425 (Electronic)
IS  - 2073-4425 (Linking)
VI  - 12
IP  - 2
DP  - 2021 Feb 14
TI  - Retinal Oxygenation in Inherited Diseases of the Retina.
LID - 10.3390/genes12020272 [doi]
LID - 272
AB  - (1) Background: The aim of our study was to investigate the relationship between 
      retinal metabolic alterations (retinal vessel oximetry, RO) and structural 
      findings (retinal vessel diameter, central retinal thickness and retinal nerve 
      fiber layer thickness, RNFL) in patients with inherited retinal diseases (IRDs). 
      (2) Methods: A total of 181 eyes of 92 subjects were examined: 121 eyes of 62 
      patients with IRDs were compared to 60 eyes of 30 healthy age-matched controls. 
      The retinal vessel oximetry was performed with the oxygen saturation measurement 
      tool of the Retinal Vessel Analyser (RVA; IMEDOS Systems UG, Jena, Germany). The 
      oxygen saturation in all four major peripapillary retinal arterioles (A-SO(2); %) 
      and venules (V-SO(2); %) were measured and their difference (A-V SO(2); %) was 
      calculated. Additionally, retinal vessel diameters of the corresponding 
      arterioles (D-A; microm) and venules (D-V; microm) were determined. The peripapillary 
      central retinal thickness and the RNFL thickness were measured using spectral 
      domain optical coherence tomography (SD-OCT) (Carl Zeiss Meditec, Dublin, CA, 
      USA). Moreover, we calculated the mean central retinal oxygen exposure (cO(2)-E; 
      %/microm) and the mean peripapillary oxygen exposure (pO(2)-E; %/microm) per micron of 
      central retinal thickness and nerve fiber layer thickness by dividing the mean 
      central retinal thickness (CRT) and the RNFL thickness with the mean A-V SO(2). 
      (3) Results: Rod-cone dystrophy patients had the highest V-SO(2) and A-SO(2), the 
      lowest A-V SO(2), the narrowest D-A and D-V and the thickest RNFL, when compared 
      not only to controls (p </= 0.040), but also to patients with other IRDs. 
      Furthermore, in rod-cone dystrophies the cO(2)-E and the pO(2)-E were higher in 
      comparison to controls and to patients with other IRDs (p </= 0.005). Cone-rod 
      dystrophy patients had the lowest cO(2)-E compared to controls and patients with 
      other IRDs (p </= 0.035). Evaluated in central zones, the cO(2)-E was significantly 
      different when comparing cone-rod dystrophy (CRD) against rod-cone dystrophy 
      (RCD) patients in all zones (p < 0.001), whereas compared with controls and 
      patients with inherited macular dystrophy this was observed only in zones 1 and 2 
      (p </= 0.018). The oxygen exposure was also the highest in the RCD group for both 
      the nasal and the temporal peripapillary area, among all the evaluated groups (p 
      </= 0.025). (4) Conclusions: The presented metabolic-structural approach enhances 
      our understanding of inherited photoreceptor degenerations. Clearly demonstrated 
      through the O(2)-E comparisons, the central and the peripapillary retina in 
      rod-cone dystrophy eyes consume less oxygen than the control-eyes and eyes with 
      other IRDs. Rod-cone dystrophy eyes seem to be proportionally more exposed to 
      oxygen, the later presumably leading to more pronounced oxidative damage-related 
      remodeling.
FAU - Turksever, Cengiz
AU  - Turksever C
AD  - VISTA Clinic Binningen BL, 4201 Binningen, Switzerland.
FAU - Lopez Torres, Lisette T
AU  - Lopez Torres LT
AD  - Department of Ophthalmology, University of Basel, 4056 Basel, Switzerland.
FAU - Valmaggia, Christophe
AU  - Valmaggia C
AD  - Department of Ophthalmology, University of Basel, 4056 Basel, Switzerland.
AD  - Department of Ophthalmology, Cantonal Hospital, 9007 St. Gallen, Switzerland.
AD  - Department of Ophthalmology, University of Zurich, 8091 Zurich, Switzerland.
FAU - Todorova, Margarita G
AU  - Todorova MG
AUID- ORCID: 0000-0001-8326-1449
AD  - Department of Ophthalmology, University of Basel, 4056 Basel, Switzerland.
AD  - Department of Ophthalmology, Cantonal Hospital, 9007 St. Gallen, Switzerland.
AD  - Department of Ophthalmology, University of Zurich, 8091 Zurich, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20210214
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Female
MH  - Germany
MH  - Humans
MH  - Macular Degeneration/diagnostic imaging/genetics/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Oximetry
MH  - Oxygen/metabolism
MH  - Oxygen Consumption/genetics
MH  - Retina/diagnostic imaging/*metabolism/pathology
MH  - Retinal Vessels/diagnostic imaging/metabolism/pathology
MH  - Retinitis Pigmentosa/diagnostic imaging/*genetics/pathology
PMC - PMC7918478
OTO - NOTNLM
OT  - inherited retinal diseases
OT  - metabolism-structure relationship
OT  - oxygen exposure
OT  - retinal vessel oxygen saturation
COIS- The authors declare no conflict of interest.
EDAT- 2021/03/07 06:00
MHDA- 2021/07/27 06:00
PMCR- 2021/02/14
CRDT- 2021/03/06 01:14
PHST- 2021/01/13 00:00 [received]
PHST- 2021/02/06 00:00 [revised]
PHST- 2021/02/07 00:00 [accepted]
PHST- 2021/03/06 01:14 [entrez]
PHST- 2021/03/07 06:00 [pubmed]
PHST- 2021/07/27 06:00 [medline]
PHST- 2021/02/14 00:00 [pmc-release]
AID - genes12020272 [pii]
AID - genes-12-00272 [pii]
AID - 10.3390/genes12020272 [doi]
PST - epublish
SO  - Genes (Basel). 2021 Feb 14;12(2):272. doi: 10.3390/genes12020272.