PMID- 33673219
OWN - NLM
STAT- MEDLINE
DCOM- 20210423
LR  - 20210423
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 18
IP  - 4
DP  - 2021 Feb 12
TI  - Prenatal Exposure to Mixtures of Phthalates, Parabens, and Other Phenols and 
      Obesity in Five-Year-Olds in the CHAMACOS Cohort.
LID - 10.3390/ijerph18041796 [doi]
LID - 1796
AB  - Exposures to phthalates, parabens, and other phenols are often correlated due to 
      their ubiquitous use in personal care products and plastics. Examining these 
      compounds as a complex mixture may clarify inconsistent relationships between 
      individual chemicals and childhood adiposity. Using data from the Center for the 
      Health Assessment of Mothers and Children of Salinas (CHAMACOS) study, a 
      longitudinal cohort of children in Salinas Valley, California (n = 309), we 
      examined biomarkers of 11 phthalate metabolites and 9 phenols, including several 
      parabens and bisphenol A, measured in maternal urine at two time points during 
      pregnancy. We measured child height and weight at age five to calculate the body 
      mass index (BMI) z-scores and overweight/obesity status. The association between 
      prenatal urinary concentrations of biomarkers with the childhood BMI z-score and 
      overweight/obesity status was analyzed using single-pollutant models and two 
      mixture methods: Bayesian hierarchical modeling (BMH) and Bayesian kernel machine 
      regression (BKMR). Urinary concentrations of monoethyl phthalate, 
      monocarboxy-isononly phthalate (metabolites of diethyl phthalate and di-isodecyl 
      phthalate, respectively), and propylparaben were consistently associated with an 
      increased BMI z-score and overweight/obesity status across all modeling 
      approaches. Higher prenatal exposures to the cumulative biomarker mixture also 
      trended with greater childhood adiposity. These results, robust across two 
      methods that control for co-pollutant confounding, suggest that prenatal exposure 
      to certain phthalates and parabens may increase the risk for obesity in early 
      childhood.
FAU - Berger, Kimberly
AU  - Berger K
AUID- ORCID: 0000-0001-6831-1065
AD  - Sequoia Foundation, La Jolla, CA 92037, USA.
FAU - Hyland, Carly
AU  - Hyland C
AUID- ORCID: 0000-0002-6840-2351
AD  - Center for Environmental Research and Children's Health (CERCH), School of Public 
      Health, University of California at Berkeley, Berkeley, CA 94704, USA.
FAU - Ames, Jennifer L
AU  - Ames JL
AD  - Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, 
      USA.
FAU - Mora, Ana M
AU  - Mora AM
AUID- ORCID: 0000-0002-2008-9714
AD  - Center for Environmental Research and Children's Health (CERCH), School of Public 
      Health, University of California at Berkeley, Berkeley, CA 94704, USA.
AD  - Central American Institute for Studies on Toxic Substances (IRET), Universidad 
      Nacional, Heredia 40101, Costa Rica.
FAU - Huen, Karen
AU  - Huen K
AD  - Center for Environmental Research and Children's Health (CERCH), School of Public 
      Health, University of California at Berkeley, Berkeley, CA 94704, USA.
FAU - Eskenazi, Brenda
AU  - Eskenazi B
AD  - Center for Environmental Research and Children's Health (CERCH), School of Public 
      Health, University of California at Berkeley, Berkeley, CA 94704, USA.
FAU - Holland, Nina
AU  - Holland N
AD  - Center for Environmental Research and Children's Health (CERCH), School of Public 
      Health, University of California at Berkeley, Berkeley, CA 94704, USA.
FAU - Harley, Kim G
AU  - Harley KG
AD  - Center for Environmental Research and Children's Health (CERCH), School of Public 
      Health, University of California at Berkeley, Berkeley, CA 94704, USA.
LA  - eng
GR  - P01 ES009605/ES/NIEHS NIH HHS/United States
GR  - R01 ES021369/ES/NIEHS NIH HHS/United States
GR  - RC2 ES018792/ES/NIEHS NIH HHS/United States
GR  - R21 ES024909/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20210212
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Environmental Pollutants)
RN  - 0 (Parabens)
RN  - 0 (Phenols)
RN  - 0 (Phthalic Acids)
RN  - 6O7F7IX66E (phthalic acid)
SB  - IM
MH  - Bayes Theorem
MH  - Child
MH  - Child, Preschool
MH  - Environmental Exposure/adverse effects/analysis
MH  - *Environmental Pollutants/toxicity
MH  - Female
MH  - Humans
MH  - Obesity/chemically induced/epidemiology
MH  - Parabens/adverse effects
MH  - Phenols/toxicity
MH  - *Phthalic Acids/toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/chemically induced/epidemiology
PMC - PMC7918439
OTO - NOTNLM
OT  - Bayesian
OT  - children's health
OT  - endocrine disruptors
OT  - mixtures
OT  - obesity
OT  - parabens
OT  - phenols
OT  - phthalates
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2021/03/07 06:00
MHDA- 2021/04/24 06:00
PMCR- 2021/02/01
CRDT- 2021/03/06 01:15
PHST- 2021/01/18 00:00 [received]
PHST- 2021/02/06 00:00 [revised]
PHST- 2021/02/08 00:00 [accepted]
PHST- 2021/03/06 01:15 [entrez]
PHST- 2021/03/07 06:00 [pubmed]
PHST- 2021/04/24 06:00 [medline]
PHST- 2021/02/01 00:00 [pmc-release]
AID - ijerph18041796 [pii]
AID - ijerph-18-01796 [pii]
AID - 10.3390/ijerph18041796 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2021 Feb 12;18(4):1796. doi: 
      10.3390/ijerph18041796.