PMID- 33675543
OWN - NLM
STAT- MEDLINE
DCOM- 20210616
LR  - 20210616
IS  - 1097-0096 (Electronic)
IS  - 0091-2751 (Linking)
VI  - 49
IP  - 6
DP  - 2021 Jul
TI  - Clinical value of 2D speckle tracking imaging in evaluating the effect of 
      percutaneous intramyocardial septal radiofrequency ablation in patients with 
      hypertrophic obstructive cardiomyopathy.
PG  - 554-562
LID - 10.1002/jcu.22989 [doi]
AB  - PURPOSE: To explore the short-term changes after percutaneous intramyocardial 
      septal radiofrequency ablation (PIMSRA) in patients with hypertrophic obstructive 
      cardiomyopathy (HOCM), using quantitative analysis of two-dimensional speckle 
      tracking imaging (2D-STI). METHODS: This prospective self-controlled study 
      included 30 HOCM patients treated with PIMSRA. The study for each patient spanned 
      over at least 1 year. Interventricular septal thickness and the left ventricular 
      outflow tract peak pressure gradient (LVOT-PG) were measured through 
      echocardiography, and 2D-STI was used to evaluate the left ventricular (LV) 
      systolic function and synchrony. Cardiac function was assessed using the New York 
      Heart Association's (NYHA) functional classification for cardiac disease, and 
      through the serum levels of cardiac troponin I (cTnI) and N-terminal pro-B-type 
      natriuretic peptide (NT-proBNP). Biomarkers procollagen type I carboxy-terminal 
      propeptide (PICP) and matrix metalloproteinases-2 (MMP-2) were detected for 
      noninvasive assessment of myocardial fibrosis. RESULTS: The patients' 
      interventricular septal thickness, LVOT-PG, NYHA class, and plasma PICP and MMP-2 
      levels at the first month postoperatively were significantly lower than before 
      operation (all P < .05). The 2D-STI quantitative variables of LV systolic 
      function and synchrony improved significantly (all P < .05). They improved 
      further 1 year postoperatively (P < .01 or P < .001). Serum cTnI and NT-proBNP 
      levels increased 1 month postoperatively, but significantly decreased 1 year 
      postoperatively (both P < .05). Pearson or Spearman correlation analysis showed 
      that the improvement of interventricular septal thickness, LVOT-PG, NYHA class, 
      and the levels of cTnI, NT-proBNP, PICP and MMP-2, were in positive correlation 
      with the restoration of LV systolic function and synchrony (P < .01 or P < .001). 
      CONCLUSION: The changes in 2D-STI quantitative variables related to LV systolic 
      function and synchrony are closely correlated with the improvement of cardiac 
      function in HOCM patients after PIMSRA. These 2D-STI variables can serve for 
      objective, accurate, and noninvasive evaluation of the HOCM treatment.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Qian, Dajun
AU  - Qian D
AUID- ORCID: 0000-0003-0582-0131
AD  - Department of Cardiac Function, Wuxi People's Hospital, Wuxi, China.
FAU - Zhou, Xiaojun
AU  - Zhou X
AD  - Department of Cardiac Function, Wuxi People's Hospital, Wuxi, China.
FAU - Liu, Huan
AU  - Liu H
AD  - Department of Cardiac Function, Wuxi People's Hospital, Wuxi, China.
FAU - Cao, Lijun
AU  - Cao L
AD  - Department of Cardiac Function, Wuxi People's Hospital, Wuxi, China.
LA  - eng
PT  - Journal Article
DEP - 20210306
PL  - United States
TA  - J Clin Ultrasound
JT  - Journal of clinical ultrasound : JCU
JID - 0401663
RN  - 0 (Peptide Fragments)
RN  - 0 (Troponin T)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Cardiomyopathy, Hypertrophic/blood/*diagnostic imaging/physiopathology/*therapy
MH  - *Echocardiography
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Prospective Studies
MH  - *Radiofrequency Ablation
MH  - Systole
MH  - Treatment Outcome
MH  - Troponin T/blood
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - echocardiography
OT  - hypertrophic obstructive cardiomyopathy
OT  - percutaneous intramyocardial septal radiofrequency ablation
OT  - quantitative analysis
OT  - systolic synchrony
OT  - two-dimensional speckle tracking imaging
EDAT- 2021/03/07 06:00
MHDA- 2021/06/17 06:00
CRDT- 2021/03/06 12:08
PHST- 2021/01/23 00:00 [revised]
PHST- 2020/09/29 00:00 [received]
PHST- 2021/01/23 00:00 [accepted]
PHST- 2021/03/07 06:00 [pubmed]
PHST- 2021/06/17 06:00 [medline]
PHST- 2021/03/06 12:08 [entrez]
AID - 10.1002/jcu.22989 [doi]
PST - ppublish
SO  - J Clin Ultrasound. 2021 Jul;49(6):554-562. doi: 10.1002/jcu.22989. Epub 2021 Mar 
      6.