PMID- 33675677
OWN - NLM
STAT- MEDLINE
DCOM- 20220315
LR  - 20220315
IS  - 1099-1077 (Electronic)
IS  - 0885-6222 (Linking)
VI  - 36
IP  - 5
DP  - 2021 Sep
TI  - Resting state functional connectivity in adolescent synthetic cannabinoid users 
      with and without attention-deficit/hyperactivity disorder.
PG  - e2781
LID - 10.1002/hup.2781 [doi]
AB  - OBJECTIVE: Synthetic cannabinoids (SCs) have become increasingly popular in 
      recent years, especially among adolescents. The first aim of the current study 
      was to examine resting-state functional connectivity (rsFC) in SC users compared 
      to controls. Our second aim was to examine the influence of comorbid 
      attention-deficit/hyperactivity disorder (ADHD) symptomatology on rsFC changes in 
      SC users compared to controls. METHODS: Resting-state functional magnetic 
      resonance imaging (fMRI) analysis included 25 SC users (14 without ADHD and 11 
      with ADHD combined type) and 12 control subjects. RESULTS: We found (i) higher 
      rsFC between the default mode network (DMN) and salience network, dorsal 
      attention network and cingulo-opercular network, and (ii) lower rsFC within the 
      DMN and between the DMN and visual network in SC users compared to controls. 
      There were no significant differences between SC users with ADHD and controls, 
      nor were there any significant differences between SC users with and without 
      ADHD. CONCLUSIONS: We found the first evidence of abnormalities within and 
      between resting state networks in adolescent SC users without ADHD. In contrast, 
      SC users with ADHD showed no differences compared to controls. These results 
      suggest that comorbidity of ADHD and substance dependence may show different rsFC 
      alterations than substance use alone.
CI  - (c) 2021 John Wiley & Sons Ltd.
FAU - Yuncu, Zeki
AU  - Yuncu Z
AD  - Department of Child Psychiatry, Ege University School of Medicine, Izmir, Turkey.
FAU - Cakmak Celik, Zehra
AU  - Cakmak Celik Z
AD  - Department of Child Psychiatry, Cizre State Hospital, Sirnak, Turkey.
FAU - Colak, Cigdem
AU  - Colak C
AD  - Department of Psychiatry, Cigli Regional Training Hospital, Izmir, Turkey.
FAU - Thapa, Tribikram
AU  - Thapa T
AD  - Brain & Mental Health Laboratory, Monash Institute of Cognitive and Clinical 
      Neurosciences and School of Psychological Sciences, Monash University, Victoria, 
      Australia.
FAU - Fornito, Alex
AU  - Fornito A
AD  - Brain & Mental Health Laboratory, Monash Institute of Cognitive and Clinical 
      Neurosciences and School of Psychological Sciences, Monash University, Victoria, 
      Australia.
FAU - Bora, Emre
AU  - Bora E
AD  - Department of Psychiatry, Dokuz Eylul University Medical School, Izmir, Turkey.
FAU - Kitis, Omer
AU  - Kitis O
AD  - Department of Radiodiagnostics, Ege University School of Medicine, Izmir, Turkey.
FAU - Zorlu, Nabi
AU  - Zorlu N
AUID- ORCID: 0000-0002-2340-6156
AD  - Department of Psychiatry, Katip Celebi University, Ataturk Training and Research 
      Hospital, Izmir, Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210306
PL  - England
TA  - Hum Psychopharmacol
JT  - Human psychopharmacology
JID - 8702539
RN  - 0 (Cannabinoids)
SB  - IM
MH  - Adolescent
MH  - *Attention Deficit Disorder with Hyperactivity/diagnostic imaging/epidemiology
MH  - Brain/diagnostic imaging
MH  - Brain Mapping
MH  - *Cannabinoids/adverse effects
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Neural Pathways/diagnostic imaging
OTO - NOTNLM
OT  - ADHD
OT  - connectomics
OT  - functional connectivity
OT  - synthetic cannabinoids
EDAT- 2021/03/07 06:00
MHDA- 2022/03/16 06:00
CRDT- 2021/03/06 17:04
PHST- 2021/02/09 00:00 [received]
PHST- 2021/02/11 00:00 [accepted]
PHST- 2021/03/07 06:00 [pubmed]
PHST- 2022/03/16 06:00 [medline]
PHST- 2021/03/06 17:04 [entrez]
AID - 10.1002/hup.2781 [doi]
PST - ppublish
SO  - Hum Psychopharmacol. 2021 Sep;36(5):e2781. doi: 10.1002/hup.2781. Epub 2021 Mar 
      6.